FUNCTION Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.SUBUNIT Component of the Fanconi anemia (FA) complex. Interacts with FANCA; interaction is direct. Interacts (via UBZ2-type zinc finger) with REV1; this interaction contributes to the stable association of the two proteins in nuclear foci in response to replication stress. Reported to bind monoubiquitinated REV1; however it binds better to non-ubiquitinated REV1 (PubMed:22266823).INTERACTION Following DNA damage, recruited to DNA interstrand cross-links (ICLs) sites by binding to ubiquitin generated by RNF8.ALTERNATIVE PRODUCTS The UBZ2-type zinc finger binds both 'Lys-48'- and 'Lys-63'-linked polyubiquitin with preference for 'Lys-63'-linked polyubiquitin.MISCELLANEOUS May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.CAUTION According to a report, ubiquitin-binding is dispensable for function (PubMed:22396592). However, such data are not confirmed by PubMed:22705371.SEQUENCE CAUTION Extended N-terminus.
recommendedName: fullName evidence="15"Fanconi anemia core complex-associated protein 20 alternativeName: fullName evidence="10"FANCA-associated protein of 20 kDa alternativeName: fullName evidence="10"Fanconi anemia-associated protein of 20 kDa
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