UniProt:Q6NT55 CYP4F22

chain
  • chain:1-531
checksum 32E801893EB8C536
comment
  • FUNCTION A cytochrome P450 monooxygenase involved in epidermal ceramide biosynthesis. Hydroxylates the terminal carbon (omega-hydroxylation) of ultra-long-chain fatty acyls (C28-C36) prior to ceramide synthesis (PubMed:26056268). Contributes to the synthesis of three classes of omega-hydroxy-ultra-long chain fatty acylceramides having sphingosine, 6-hydroxysphingosine and phytosphingosine bases, all major lipid components that underlie the permeability barrier of the stratum corneum (PubMed:26056268). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:26056268).CATALYTIC ACTIVITY triacontanoate + reduced [NADPH--hemoprotein reductase] + O2 = omega-hydroxy-triacontanoate + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)CATALYTIC ACTIVITY an omega-methyl-ultra-long-chain fatty acid + reduced [NADPH--hemoprotein reductase] + O2 = an omega-hydroxy-ultra-long-chain fatty acid + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)COFACTOR The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the cytochrome P450 family.CAUTION A second transmembrane domain at positions 95-115 is predicted by three programs ESKW, MEMSAT and Phobius. However experimental evidence supports the presence of a single signal-anchor transmembrane domain at the N-terminus.
created [InstanceEdit:211033] Jassal, B, 2008-01-25 15:39:22
crossReference
databaseName UniProt
dbId 211029
description
  • recommendedName: fullName evidence="6"Ultra-long-chain fatty acid omega-hydroxylase ecNumber evidence="4"1.14.14.177 alternativeName: fullName evidence="5"Cytochrome P450 4F22
displayName UniProt:Q6NT55 CYP4F22
geneName
  • CYP4F22
identifier Q6NT55
isSequenceChanged false
keyword
  • Endoplasmic reticulum
  • Heme
  • Ichthyosis
  • Iron
  • Lipid metabolism
  • Membrane
  • Metal-binding
  • Microsome
  • Monooxygenase
  • Oxidoreductase
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • CYP4F22
otherIdentifier
  • 11733532_at
  • 11733533_at
  • 126410
  • 16859117
  • 244692_PM_at
  • 244692_at
  • 3823211
  • 3823212
  • 3823215
  • 3823217
  • 3823218
  • 3823219
  • 3823220
  • 3823221
  • 3823222
  • 3823223
  • 3823225
  • 3823227
  • 3823228
  • 3823229
  • 3823231
  • 3823232
  • 3823233
  • 8026424
  • 91481_at
  • GE85609
  • GO:0004497
  • GO:0005506
  • GO:0005515
  • GO:0005783
  • GO:0005789
  • GO:0006629
  • GO:0006690
  • GO:0016020
  • GO:0016491
  • GO:0016705
  • GO:0020037
  • GO:0046513
  • GO:0046872
  • HMNXSV003000467
  • Hs.156452.0.A1_3p_at
  • ILMN_1708303
  • PH_hs_0009443
  • TC19000272.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CP4FN_HUMAN
  • Q8N8H4
sequenceLength 531
species [Species:48887] Homo sapiens
stId uniprot:Q6NT55
url http://purl.uniprot.org/uniprot/Q6NT55
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