UniProt:Q6IQ16 SPOPL

chain
  • chain:1-392
checksum CEB4243BD732DFEF
comment
  • FUNCTION Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, but with relatively low efficiency. Cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL are less efficient than ubiquitin ligase complexes containing only SPOP. May function to down-regulate the activity of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that contain SPOP.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Homodimer. Heterodimer with SPOP. Component of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL. Interacts with CUL3 and MACROH2A1.INTERACTION Belongs to the Tdpoz family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 249200
description
  • recommendedName: Speckle-type POZ protein-like alternativeName: HIB homolog 2 alternativeName: Roadkill homolog 2
displayName UniProt:Q6IQ16 SPOPL
geneName
  • SPOPL
identifier Q6IQ16
isSequenceChanged false
keyword
  • Nucleus
  • Proteomics identification
  • Reference proteome
  • Ubl conjugation pathway
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • SPOPL
otherIdentifier
  • 11724643_at
  • 11724644_at
  • 11724645_at
  • 11758137_s_at
  • 16886130
  • 225658_PM_at
  • 225658_at
  • 225659_PM_at
  • 225659_at
  • 243170_PM_at
  • 243170_at
  • 2508017
  • 2508027
  • 2508028
  • 2508030
  • 2508031
  • 2508032
  • 2508033
  • 2508034
  • 2508036
  • 2508037
  • 2508040
  • 2508042
  • 2508045
  • 2508048
  • 2508049
  • 2508050
  • 2508051
  • 2508054
  • 2508055
  • 2508056
  • 2508057
  • 2508058
  • 2508059
  • 2508061
  • 2772228
  • 339745
  • 43054_r_at
  • 52421_at
  • 58783_at
  • 67402_at
  • 8045514
  • 91171_at
  • A_23_P79681
  • A_24_P551028
  • GE555280
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0016567
  • GO:0030162
  • GO:0030163
  • GO:0031397
  • GO:0031463
  • GO:0031625
  • GO:0042802
  • GO:0043161
  • HMNXSV003007253
  • HMNXSV003043622
  • Hs.125790.1.A1_3p_at
  • Hs.125790.1.A2_3p_at
  • Hs.185018.0.A1_3p_at
  • ILMN_1807649
  • ILMN_2095506
  • PH_hs_0032058
  • TC02000894.hg
  • p10033
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SPOPL_HUMAN
sequenceLength 392
species [Species:48887] Homo sapiens
stId uniprot:Q6IQ16
url http://purl.uniprot.org/uniprot/Q6IQ16
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