UniProt:Q6IAN0 DHRS7B

chain
  • chain:1-325
checksum 18F4A4C40D3B95CE
comment
  • FUNCTION Reductase required for adipogenesis and activation of PPARG nuclear receptor. Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively, synthesizing ether-linked phospholipids that act as agonists for PPARG. Also regulates adipogenesis by preventing adipocyte browning: following import into the nucleus, interacts with PRDM16, inhibiting the interaction between PRDM16 and PPARG and preventing differentiation of brown adipocytes.CATALYTIC ACTIVITY 1-hexadecanoyl-sn-glycero-3-phosphate + NADP(+) = 1-hexadecanoylglycerone 3-phosphate + NADPH + H(+)CATALYTIC ACTIVITY a 1-O-alkylglycerone 3-phosphate + NADPH + H(+) = a 1-O-alkyl-sn-glycero-3-phosphate + NADP(+)SUBUNIT Interacts with PRDM16; preventing the interaction between PRDM16 and PPARG.SUBCELLULAR LOCATION Belongs to the short-chain dehydrogenases/reductases (SDR) family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 227569
description
  • recommendedName: Peroxisomal reductase activating PPAR-gamma shortName: PexRAP ecNumber evidence="3"1.1.1.101 alternativeName: fullName evidence="6"Dehydrogenase/reductase SDR family member 7B alternativeName: fullName evidence="6"Short-chain dehydrogenase/reductase family 32C member 1 shortName evidence="6"Protein SDR32C1
displayName UniProt:Q6IAN0 DHRS7B
geneName
  • DHRS7B
  • SDR32C1
  • CGI-93
  • UNQ212/PRO238
identifier Q6IAN0
isSequenceChanged false
keyword
  • Endoplasmic reticulum
  • Membrane
  • NAD
  • NADP
  • Nucleus
  • Oxidoreductase
  • Peroxisome
  • Proteomics identification
  • Reference proteome
  • Signal-anchor
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • DHRS7B
otherIdentifier
  • 11718373_at
  • 16832255
  • 220690_PM_s_at
  • 220690_s_at
  • 25979
  • 3714660
  • 3714661
  • 3714677
  • 3714679
  • 3714680
  • 3714681
  • 3714682
  • 3714685
  • 3714687
  • 3714688
  • 3714689
  • 3714692
  • 3714693
  • 3714694
  • 3714695
  • 3714696
  • 52920_at
  • 8005699
  • A_23_P141208
  • A_24_P130352
  • A_24_P279520
  • GE82012
  • GO:0000140
  • GO:0005737
  • GO:0005778
  • GO:0005783
  • GO:0005789
  • GO:0006629
  • GO:0008611
  • GO:0016020
  • GO:0016491
  • GO:0016616
  • GO:0043226
  • HMNXSV003051686
  • ILMN_1707901
  • PH_hs_0001100
  • PH_hs_0039450
  • TC17000295.hg
  • g7661657_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PEXRP_HUMAN
  • B5MEF4
  • Q6UX59
  • Q9BTF9
  • Q9UFM6
  • Q9Y3A1
sequenceLength 325
species [Species:48887] Homo sapiens
stId uniprot:Q6IAN0
url http://purl.uniprot.org/uniprot/Q6IAN0
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