Reactome | UniProt:Q6GTX8 LAIR1

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UniProt:Q6GTX8 LAIR1 Show undefined attributes

chain	signal peptide:1-21 chain:22-287
checksum	E2A921D84F426B35
comment	FUNCTION Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.SUBUNIT Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK. Binds with high affinity to extracellular matrix collagens, the interaction is functionally important.INTERACTION Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection.DEVELOPMENTAL STAGE Complete loss of expression when naive B-cells proliferates and differentiates into Ig-producing plasma cells under in vitro stimulation.INDUCTION By T-cell receptor stimulation in a process that requires p38 MAP kinase and ERK signaling.DOMAIN ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down-regulation of cell activation.PTM Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK.PTM N-glycosylated.MISCELLANEOUS Functions as an inhibitory receptor in NK cells and T-cells.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:11834672] HPA:ENSG00000167613-LAIR1 [DatabaseIdentifier:12437913] RefSeq:NP_068352.2 [DatabaseIdentifier:12437914] RefSeq:NP_001275952.2 [DatabaseIdentifier:12437912] RefSeq:NP_002278.2 [DatabaseIdentifier:12437911] RefSeq:NP_001275954.2 [DatabaseIdentifier:12279459] Pharos - Targets:Q6GTX8 [DatabaseIdentifier:12257697] PRO:Q6GTX8 [DatabaseIdentifier:12139988] PDB:3KGR [DatabaseIdentifier:12139986] PDB:7F9L [DatabaseIdentifier:12139987] PDB:7F9M [DatabaseIdentifier:12139985] PDB:3RP1 [DatabaseIdentifier:12139989] PDB:7F9N [DatabaseIdentifier:12119118] OpenTargets:ENSG00000167613 [DatabaseIdentifier:11504326] ENSEMBL:ENSG00000276053 [DatabaseIdentifier:11504325] ENSEMBL:ENSG00000276163 [DatabaseIdentifier:11504327] ENSEMBL:ENSG00000278154 [DatabaseIdentifier:11504324] ENSEMBL:ENSG00000274110 [DatabaseIdentifier:11504328] ENSEMBL:ENSG00000167613 [DatabaseIdentifier:11616304] ENSEMBL:ENSP00000479133 [DatabaseIdentifier:11616301] ENSEMBL:ENSP00000375622 [DatabaseIdentifier:11616297] ENSEMBL:ENSP00000479707 [DatabaseIdentifier:11616305] ENSEMBL:ENSP00000479006 [DatabaseIdentifier:11616302] ENSEMBL:ENSP00000479682 [DatabaseIdentifier:11616303] ENSEMBL:ENSP00000301193 [DatabaseIdentifier:11616299] ENSEMBL:ENSP00000482922 [DatabaseIdentifier:11616296] ENSEMBL:ENSP00000480619 [DatabaseIdentifier:11616307] ENSEMBL:ENSP00000418998 [DatabaseIdentifier:11616308] ENSEMBL:ENSP00000478405 [DatabaseIdentifier:11616309] ENSEMBL:ENSP00000479649 [DatabaseIdentifier:11616300] ENSEMBL:ENSP00000481204 [DatabaseIdentifier:11616306] ENSEMBL:ENSP00000478853 [DatabaseIdentifier:11616298] ENSEMBL:ENSP00000480659 [DatabaseIdentifier:11738995] ENSEMBL:ENST00000610549 [DatabaseIdentifier:11739003] ENSEMBL:ENST00000616612 [DatabaseIdentifier:11738998] ENSEMBL:ENST00000348231 [DatabaseIdentifier:11739006] ENSEMBL:ENST00000474878 [DatabaseIdentifier:11739005] ENSEMBL:ENST00000620726 [DatabaseIdentifier:11739002] ENSEMBL:ENST00000391742 [DatabaseIdentifier:11738996] ENSEMBL:ENST00000614946 [DatabaseIdentifier:11738997] ENSEMBL:ENST00000614937 [DatabaseIdentifier:11739007] ENSEMBL:ENST00000620077 [DatabaseIdentifier:11739008] ENSEMBL:ENST00000620357 [DatabaseIdentifier:11739001] ENSEMBL:ENST00000619717 [DatabaseIdentifier:11738999] ENSEMBL:ENST00000622097 [DatabaseIdentifier:11739000] ENSEMBL:ENST00000619817 [DatabaseIdentifier:11739004] ENSEMBL:ENST00000618434 [DatabaseIdentifier:11778697] Guide to Pharmacology - Targets:2974 [DatabaseIdentifier:11781544] GeneCards:LAIR1 [DatabaseIdentifier:11829006] HMDB Protein:HMDBP07769
databaseName	UniProt
dbId	234771
description	recommendedName: Leukocyte-associated immunoglobulin-like receptor 1 shortName: LAIR-1 shortName: hLAIR1 cdAntigenNameCD305/cdAntigenName
displayName	UniProt:Q6GTX8 LAIR1
geneName	LAIR1 CD305
identifier	Q6GTX8
isSequenceChanged	false
keyword	3D-structure Adaptive immunity Alternative splicing Cell membrane Disulfide bond Glycoprotein Immunity Immunoglobulin domain Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9948485] Weiser, Joel, 2025-05-21
moleculeType	Protein
name	LAIR1
otherIdentifier	11724804_x_at 11724805_a_at 11740754_a_at 11748339_a_at 11748340_x_at 208071_PM_s_at 208071_s_at 210644_PM_s_at 210644_s_at 37470_at 3841388 3841509 3841511 3841512 3841513 3870820 3870822 3870823 3870825 3870826 3870827 3870828 3870829 3870830 3870831 3870832 3870833 3870834 3870835 3870836 3870837 3870838 3870839 3870840 3870841 3870842 3870843 3870846 3870847 3870848 3870849 3870850 3870853 3870854 3903 8039257 90514_at A_23_P209135 A_24_P262688 A_33_P3253394 A_33_P3355230 GE54119 GE844549 GO:0002250 GO:0002376 GO:0002764 GO:0005515 GO:0005886 GO:0016020 GO:0035579 GO:0070821 HMNXSV003018760 HMNXSV003020504 ILMN_1768598 ILMN_2389211 PH_hs_0019448 PH_hs_0021375 TC19001844.hg g10947100_3p_a_at g11231178_3p_a_at g6563041_3p_a_at p8451
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6799644] LAIR1 [specific granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-5686426] LAIR1 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800947] LAIR1 [tertiary granule membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000167613] ENSEMBL:ENSG00000167613 LAIR1 [ReferenceDNASequence:12759565] UCSC:Q6GTX8 LAIR1 [ReferenceDNASequence:12105048] OMIM:602992 LAIR1 [ReferenceDNASequence:12083809] NCBI Gene:3903 LAIR1 [ReferenceDNASequence:11999716] Monarch:3903 LAIR1 [ReferenceDNASequence:11908104] KEGG:hsa:3903 LAIR1 [ReferenceDNASequence:11369927] BioGPS Gene:3903 LAIR1 [ReferenceDNASequence:11402385] COSMIC - genes:LAIR1 LAIR1 [ReferenceDNASequence:11404652] CTD Gene:3903 LAIR1 [ReferenceDNASequence:11439861] dbSNP Gene:3903 LAIR1 [ReferenceDNASequence:11813144] HGNC:6477 LAIR1
referenceTranscript	[ReferenceRNASequence:12619431] RefSeq:NM_002287.6 LAIR1 [ReferenceRNASequence:12619429] RefSeq:NM_001289023.3 LAIR1 [ReferenceRNASequence:12619428] RefSeq:NM_021706.5 LAIR1 [ReferenceRNASequence:12619430] RefSeq:NM_001289025.2 LAIR1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	LAIR1_HUMAN
sequenceLength	287
species	[Species:48887] Homo sapiens
stId	uniprot:Q6GTX8
url	http://purl.uniprot.org/uniprot/Q6GTX8

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6799644] LAIR1 [specific granule membrane] [EntityWithAccessionedSequence:R-HSA-5686426] LAIR1 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-6800947] LAIR1 [tertiary granule membrane]
(interactor)	[UndirectedInteraction:11232735] UniProt:P29350 <-> UniProt:Q6GTX8 (IntAct)