UniProt:Q68DK7 MSL1

chain
  • chain:1-614
checksum D48D845C1C2ABF45
comment
  • FUNCTION Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16227571, PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:22547026). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (PubMed:21726816, PubMed:30930284). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816).SUBUNIT Component of a multisubunit histone acetyltransferase complex (MSL) at least composed of the KAT8/MOF/MYST1, MSL1/hampin, MSL2 and MSL3 (PubMed:16227571, PubMed:16543150, PubMed:21217699, PubMed:22547026, PubMed:30224647, PubMed:33837287). Forms a MSL heterotetrameric core with MSL2 (PubMed:16227571). Interacts (via PEHE domain) with KAT8 (via HAT domain) and MSL3 (via MRG domain); both interactions are direct (PubMed:21217699, PubMed:22547026, PubMed:30224647). Directly interacts with NUPR1 (PubMed:19650074). Interacts with TP53BP1; this interaction may be required for MSL1 DNA repair activity, but not for histone acetyltransferase activity (PubMed:19650074). Interacts with TTC4, ECM2 and PIHD1 (By similarity).INTERACTION Up-regulated by gamma-irradiation.DOMAIN The coiled coil is formed by helices from two subunits in the MSL1 homodimer.PTM Sumoylated with SUMO1.SIMILARITY Belongs to the msl-1 family.
created [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39
crossReference
databaseName UniProt
dbId 385598
description
  • recommendedName: fullName evidence="16"Male-specific lethal 1 homolog shortName evidence="16"MSL-1 alternativeName: Male-specific lethal 1-like 1 shortName: MSL1-like 1 alternativeName: Male-specific lethal-1 homolog 1
displayName UniProt:Q68DK7 MSL1
geneName
  • MSL1
  • MSL1L1
identifier Q68DK7
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Chromatin regulator
  • Coiled coil
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • MSL1
otherIdentifier
  • 11728989_a_at
  • 11745751_a_at
  • 11745752_a_at
  • 11756433_a_at
  • 11757450_s_at
  • 16833983
  • 212708_PM_at
  • 212708_at
  • 224765_PM_at
  • 224765_at
  • 32195_at
  • 339287
  • 3720742
  • 3720743
  • 3720744
  • 3720745
  • 3720746
  • 3720747
  • 3720748
  • 3720749
  • 3720751
  • 3720752
  • 3720754
  • 3720755
  • 3720756
  • 3720757
  • 3720758
  • 3720759
  • 3720760
  • 3720761
  • 3720762
  • 3720763
  • 3720764
  • 3720765
  • 3720766
  • 3720767
  • 3720769
  • 3720770
  • 3720771
  • 3720772
  • 3720773
  • 3720774
  • 3720775
  • 3720776
  • 3720777
  • 3720778
  • 3720779
  • 46240_at
  • 8007023
  • A_24_P332837
  • A_24_P500476
  • A_33_P3266873
  • A_33_P3356341
  • GE86183
  • GE86344
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0006325
  • GO:0006338
  • GO:0006355
  • GO:0016607
  • GO:0030674
  • GO:0045893
  • GO:0060090
  • GO:0072487
  • HMNXSV003039147
  • Hs.184779.0.A1_3p_at
  • Hs.272458.3.A1_3p_at
  • PH_hs_0035815
  • TC17000489.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MSL1_HUMAN
  • Q0VF46
  • Q69Z03
sequenceLength 614
species [Species:48887] Homo sapiens
stId uniprot:Q68DK7
url http://purl.uniprot.org/uniprot/Q68DK7
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