UniProt:Q66GS9 CEP135

chain
  • chain:1-1140
checksum AD56754BEBB3AA5B
comment
  • FUNCTION Centrosomal microtubule-binding protein involved in centriole biogenesis (PubMed:27477386). Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (PubMed:27185865).SUBUNIT Homodimer (PubMed:27477386). Interacts with DCTN2 (By similarity). Interacts with CEP250 (PubMed:18851962).INTERACTION During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles.ALTERNATIVE PRODUCTS Coiled-coil domains are critical for microtubule binding via the formation of a two-stranded coiled-coil structure in homodimers.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the CEP135/TSGA10 family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.SEQUENCE CAUTION Intron retention.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 225147
description
  • recommendedName: fullName evidence="15"Centrosomal protein of 135 kDa shortName: Cep135 alternativeName: Centrosomal protein 4
displayName UniProt:Q66GS9 CEP135
geneName
  • CEP135
  • CEP4
  • KIAA0635
identifier Q66GS9
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Coiled coil
  • Cytoplasm
  • Cytoskeleton
  • Disease variant
  • Disulfide bond
  • Intellectual disability
  • Phosphoprotein
  • Primary microcephaly
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • CEP135
otherIdentifier
  • 11732601_at
  • 11732602_at
  • 16966971
  • 206003_PM_at
  • 206003_at
  • 207286_3p_at
  • 207286_PM_at
  • 207286_at
  • 2727977
  • 2727978
  • 2727979
  • 2727980
  • 2727981
  • 2727982
  • 2727983
  • 2727984
  • 2727985
  • 2727986
  • 2727987
  • 2727988
  • 2727989
  • 2727990
  • 2727992
  • 2727993
  • 2727994
  • 2727995
  • 2727996
  • 2727997
  • 2727998
  • 2727999
  • 2728000
  • 2728001
  • 2728002
  • 2728003
  • 2728005
  • 2728010
  • 2728015
  • 2728016
  • 2728017
  • 2728019
  • 2728020
  • 2728021
  • 38854_at
  • 63742_r_at
  • 8095187
  • 9662
  • A_14_P133183
  • A_14_P135953
  • A_14_P136833
  • A_14_P200865
  • A_23_P18479
  • A_23_P212792
  • A_24_P140481
  • GE81949
  • GE83041
  • GO:0005515
  • GO:0005737
  • GO:0005813
  • GO:0005814
  • GO:0005815
  • GO:0005829
  • GO:0005856
  • GO:0007099
  • GO:0008017
  • GO:0008092
  • GO:0010457
  • GO:0015631
  • GO:0042802
  • GO:0042803
  • GO:0043226
  • GO:1902857
  • GO:1904951
  • HMNXSV003031493
  • ILMN_1693766
  • PH_hs_0010886
  • PH_hs_0035659
  • TC04000327.hg
  • g13376528_3p_x_at
  • g7662215_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CP135_HUMAN
  • B2RMY0
  • O75130
  • Q58F25
  • Q9H8H7
sequenceLength 1140
species [Species:48887] Homo sapiens
stId uniprot:Q66GS9
url http://purl.uniprot.org/uniprot/Q66GS9
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