Reactome | UniProt:Q658P3 STEAP3

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UniProt:Q658P3 STEAP3 Show undefined attributes

chain	chain:1-488
checksum	C89EB0D0430F9BFB
comment	FUNCTION Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:26205815). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (PubMed:15319436, PubMed:16651434).CATALYTIC ACTIVITY 2 Fe(2+) + NADP(+) + H(+) = 2 Fe(3+) + NADPHCATALYTIC ACTIVITY 2 Cu(+) + NADP(+) + H(+) = 2 Cu(2+) + NADPHCOFACTOR Homodimer. Interacts with BNIP3L, MYT1, RHBDL4/RHBDD1 and TCTP.INTERACTION Localizes to vesicular-like structures at the plasma membrane and around the nucleus.ALTERNATIVE PRODUCTS Expressed in adult bone marrow, placenta, liver, skeletal muscle and pancreas. Down-regulated in hepatocellular carcinoma.INDUCTION By p53/TP53.PTM Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner.PTM Glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the STEAP family.CAUTION Was initially thought to have tumor suppressor function in prostate cancer. However, it was shown that it is probably not the case (PubMed:12866033).
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:11484503] ENSEMBL:ENSG00000115107 [DatabaseIdentifier:11587153] ENSEMBL:ENSP00000376818 [DatabaseIdentifier:11587152] ENSEMBL:ENSP00000376819 [DatabaseIdentifier:11587154] ENSEMBL:ENSP00000376822 [DatabaseIdentifier:11709851] ENSEMBL:ENST00000393110 [DatabaseIdentifier:11709852] ENSEMBL:ENST00000393107 [DatabaseIdentifier:11709853] ENSEMBL:ENST00000393106 [DatabaseIdentifier:11796825] GeneCards:STEAP3 [DatabaseIdentifier:11812639] GlyGen:Q658P3 [DatabaseIdentifier:11834113] HMDB Protein:HMDBP08258 [DatabaseIdentifier:11849790] HPA:ENSG00000115107-STEAP3 [DatabaseIdentifier:12134490] OpenTargets:ENSG00000115107 [DatabaseIdentifier:12137901] Orphanet:STEAP3 [DatabaseIdentifier:12234901] PDB:2VNS [DatabaseIdentifier:12234902] PDB:2VQ3 [DatabaseIdentifier:12278264] PRO:Q658P3 [DatabaseIdentifier:12294651] Pharos - Targets:Q658P3 [DatabaseIdentifier:12394635] RefSeq:NP_001008410.1 [DatabaseIdentifier:12394636] RefSeq:XP_011509705.1 [DatabaseIdentifier:12394632] RefSeq:XP_054198755.1 [DatabaseIdentifier:12394633] RefSeq:NP_619543.2 [DatabaseIdentifier:12394634] RefSeq:XP_047300851.1 [DatabaseIdentifier:12394631] RefSeq:XP_054198754.1 [DatabaseIdentifier:12394630] RefSeq:NP_060704.2 [DatabaseIdentifier:12394629] RefSeq:NP_878919.2
databaseName	UniProt
dbId	249692
description	recommendedName: fullName evidence="21"Metalloreductase STEAP3 ecNumber evidence="13"1.16.1.- alternativeName: Dudulin-2 alternativeName: Six-transmembrane epithelial antigen of prostate 3 alternativeName: Tumor suppressor-activated pathway protein 6 shortName: hTSAP6 alternativeName: pHyde shortName: hpHyde
displayName	UniProt:Q658P3 STEAP3
geneName	STEAP3 TSAP6
identifier	Q658P3
isSequenceChanged	false
keyword	3D-structure Alternative splicing Apoptosis Cell cycle Copper Endosome FAD Flavoprotein Glycoprotein Heme Ion transport Iron Iron transport Membrane Metal-binding NADP Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	STEAP3
otherIdentifier	11722677_a_at 11722678_a_at 11752403_a_at 1554830_PM_a_at 1554830_a_at 16884956 218424_PM_s_at 218424_s_at 237212_PM_at 237212_at 2502780 2502782 2502783 2502787 2502789 2502790 2502793 2502794 2502796 2502797 2502798 2502799 2502800 2502801 2502802 2502803 2502804 2502805 2502806 2502807 2502808 2502809 2502810 43811_at 53159_at 55240 72259_at 8044793 A_23_P90601 A_24_P200000 GE55877 GE904980 GO:0005515 GO:0005737 GO:0005768 GO:0005771 GO:0005886 GO:0006811 GO:0006826 GO:0006915 GO:0008823 GO:0009306 GO:0010008 GO:0015677 GO:0016020 GO:0016491 GO:0020037 GO:0042802 GO:0046872 GO:0052851 GO:0071949 HMNXSV003025809 Hs.100554.0.A1_3p_at Hs2.57655.3.A1_3p_s_at ILMN_1761577 ILMN_2281089 ILMN_2383349 PH_hs_0003687 PH_hs_0005611 TC02000750.hg g8922696_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-917861] STEAP3 [endosome membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9714848] STEAP3 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000115107] ENSEMBL:ENSG00000115107 STEAP3 [ReferenceDNASequence:12744556] UCSC:Q658P3 STEAP3 [ReferenceDNASequence:11349796] BioGPS Gene:55240 STEAP3 [ReferenceDNASequence:11400421] COSMIC - genes:STEAP3 STEAP3 [ReferenceDNASequence:11426151] CTD Gene:55240 STEAP3 [ReferenceDNASequence:11437571] dbSNP Gene:55240 STEAP3 [ReferenceDNASequence:11828537] HGNC:24592 STEAP3 [ReferenceDNASequence:11889656] KEGG:hsa:55240 STEAP3 [ReferenceDNASequence:11979585] Monarch:55240 STEAP3 [ReferenceDNASequence:12063678] NCBI Gene:55240 STEAP3 [ReferenceDNASequence:12118663] OMIM:609671 STEAP3
referenceTranscript	[ReferenceRNASequence:12576399] RefSeq:XM_054342780.1 STEAP3 [ReferenceRNASequence:12576403] RefSeq:NM_001008410.2 STEAP3 [ReferenceRNASequence:12576401] RefSeq:NM_182915.3 STEAP3 [ReferenceRNASequence:12576396] RefSeq:XM_011511403.2 STEAP3 [ReferenceRNASequence:12576400] RefSeq:NM_138637.2 STEAP3 [ReferenceRNASequence:12576397] RefSeq:XM_054342779.1 STEAP3 [ReferenceRNASequence:12576398] RefSeq:XM_047444895.1 STEAP3 [ReferenceRNASequence:12576402] RefSeq:NM_018234.3 STEAP3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	STEA3_HUMAN A8K6E3 Q4VBR2 Q4ZG36 Q53SQ8 Q7Z389 Q86SF6 Q8NEW6 Q8TDP3 Q8TF03 Q9NVB5
sequenceLength	488
species	[Species:48887] Homo sapiens
stId	uniprot:Q658P3
url	http://purl.uniprot.org/uniprot/Q658P3

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-917861] STEAP3 [endosome membrane] [EntityWithAccessionedSequence:R-HSA-9714848] STEAP3 [plasma membrane]
(interactor)	[UndirectedInteraction:11216681] UniProt:Q658P3 <-> UniProt:P01111 (IntAct) [UndirectedInteraction:11216683] UniProt:Q658P3 <-> UniProt:Q8NDW8 (IntAct) [UndirectedInteraction:11216685] UniProt:Q658P3 <-> UniProt:P0DTD8 (IntAct)