UniProt:Q62280 Ss18

chain
  • initiator methionine:1
  • chain:2-418
checksum FE2BE95EA7396888
comment
  • FUNCTION Appears to function synergistically with RBM14 as a transcriptional coactivator. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner.SUBUNIT Interacts with MLLT10 (By similarity). Component of the multiprotein chromatin-remodeling complexes SWI/SNF: SWI/SNF-A (BAF), SWI/SNF-B (PBAF) and related complexes. The canonical complex contains a catalytic subunit (either SMARCA4/BRG1/BAF190A or SMARCA2/BRM/BAF190B) and at least SMARCE1, ACTL6A/BAF53, SMARCC1/BAF155, SMARCC2/BAF170, and SMARCB1/SNF5/BAF47. Other subunits specific to each of the complexes may also be present permitting several possible combinations developmentally and tissue specific. Component of the SWI/SNF (GBAF) subcomplex, which includes at least BICRA or BICRAL (mutually exclusive), BRD9, SS18, the core BAF subunits, SMARCA2/BRM, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, SMARCC1/BAF155, and SMARCD1/BAF60A (PubMed:29374058).SUBCELLULAR LOCATION Ubiquitously expressed in early embryogenesis (12.5 days). In later stages (14.5 days), the expression is restricted to cartilage forming cells, to specific neuronal cells and some epithelial derived tissues. In adults, SSXT is expressed in heart, kidney, testis and also in muscle, brain and liver. In mature testis, expression is specifically observed in primary spermatocytes.SIMILARITY Belongs to the SS18 family.
crossReference
databaseName UniProt
dbId 102347
description
  • recommendedName: Protein SSXT alternativeName: Protein SYT alternativeName: Synovial sarcoma-associated Ss18-alpha
displayName UniProt:Q62280 Ss18
geneName
  • Ss18
  • Ssxt
  • Syt
identifier Q62280
isSequenceChanged false
keyword
  • Acetylation
  • Activator
  • Nucleus
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • Ss18
otherIdentifier
  • 10457598
  • 133271_at
  • 1419360_a_at
  • 1419361_at
  • 1436257_at
  • 17352835
  • 268996
  • 4314635
  • 4323565
  • 4366272
  • 4397709
  • 4489944
  • 4507656
  • 4659891
  • 4695277
  • 4721394
  • 4733677
  • 4778760
  • 4870977
  • 4980050
  • 4994021
  • 5009785
  • 5089652
  • 5126323
  • 5143964
  • 5161840
  • 5174534
  • 5223034
  • 5335510
  • 5353005
  • 5370220
  • 5401375
  • 5424031
  • 5426344
  • 5427908
  • 5468375
  • 5469604
  • 5543425
  • 5546006
  • 99610_at
  • A_52_P67964
  • A_55_P2048202
  • GE1543935
  • GE33731
  • GO:0000226
  • GO:0000785
  • GO:0000902
  • GO:0003713
  • GO:0005634
  • GO:0005654
  • GO:0005856
  • GO:0006325
  • GO:0006338
  • GO:0006355
  • GO:0006357
  • GO:0007010
  • GO:0008284
  • GO:0009410
  • GO:0015630
  • GO:0016514
  • GO:0035556
  • GO:0045596
  • GO:0045944
  • GO:0048013
  • GO:0071564
  • GO:0097150
  • GO:0140288
  • GO:1902459
  • ILMN_1233813
  • ILMN_1245563
  • ILMN_1247448
  • ILMN_2740816
  • ILMN_2751962
  • ILMN_2751963
  • ILMN_2983228
  • X93357_s_at
  • mMC013421
  • mMR027493
  • mMR030741
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SSXT_MOUSE
  • Q3TM96
sequenceLength 418
species [Species:48892] Mus musculus
stId uniprot:Q62280
url http://purl.uniprot.org/uniprot/Q62280
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