Reactome | UniProt:Q62159 Rhoc

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UniProt:Q62159 Rhoc Show undefined attributes

chain	chain:1-190 propeptide:191-193
checksum	A193DA581560F131
comment	FUNCTION Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Regulates apical junction formation in bronchial epithelial cells.SUBUNIT Interacts with RTKN (PubMed:8662891). Interacts with AKAP13. Interacts with DIAPH1 (By similarity). Interacts with PKN2 (PubMed:20974804). Interacts with ROCK1 and ROCK2. Interacts with ARHGDIA. Interacts with RIPOR1 (By similarity).SUBCELLULAR LOCATION Translocates to the equatorial region before furrow formation in a ECT2-dependent manner.INDUCTION Up-regulated in silica-treated macrophages.SIMILARITY Belongs to the small GTPase superfamily. Rho family.
crossReference	[DatabaseIdentifier:12346330] RefSeq:NP_001278788.1 [DatabaseIdentifier:12346329] RefSeq:NP_031510.2 [DatabaseIdentifier:12255771] PRO:Q62159 [DatabaseIdentifier:11935515] MGI:106028 [DatabaseIdentifier:11811502] GlyGen:Q62159 [DatabaseIdentifier:11679682] ENSEMBL:ENSMUST00000196817 [DatabaseIdentifier:11679684] ENSEMBL:ENSMUST00000106787 [DatabaseIdentifier:11679683] ENSEMBL:ENSMUST00000002303 [DatabaseIdentifier:11556983] ENSEMBL:ENSMUSP00000002303 [DatabaseIdentifier:11556984] ENSEMBL:ENSMUSP00000142697 [DatabaseIdentifier:11556985] ENSEMBL:ENSMUSP00000102399 [DatabaseIdentifier:11462788] ENSEMBL:ENSMUSG00000002233
databaseName	UniProt
dbId	100000
description	recommendedName: Rho-related GTP-binding protein RhoC alternativeName: Silica-induced gene 61 protein shortName: SIG-61
displayName	UniProt:Q62159 Rhoc
geneName	Rhoc Arhc
identifier	Q62159
isSequenceChanged	false
keyword	Cell membrane GTP-binding Lipoprotein Membrane Methylation Nucleotide-binding Prenylation Reference proteome
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	Rhoc
otherIdentifier	10495054 11853 1435394_s_at 1448605_at 17401357 4530494 4774788 4870101 4982884 5170011 5224169 5332680 5593099 96056_at A_51_P282508 A_55_P1979684 GE34761 GO:0000166 GO:0000281 GO:0000910 GO:0003924 GO:0005515 GO:0005525 GO:0005634 GO:0005829 GO:0005886 GO:0007015 GO:0007165 GO:0007264 GO:0016020 GO:0016477 GO:0016787 GO:0019901 GO:0030335 GO:0031334 GO:0032154 GO:0032420 GO:0032956 GO:0034330 GO:0043297 GO:0044319 GO:0048870 GO:0051496 GO:1902766 ILMN_1259194 ILMN_2749437 ILMN_2790097 Msa.22074.0_f_at X80638_s_at mMC013713
physicalEntity	[EntityWithAccessionedSequence:R-MMU-9714362] RHOC [endoplasmic reticulum membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-194853] RHOC [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5625908] Rhoc [plasma membrane] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12679741] UCSC:Q62159 Rhoc [ReferenceDNASequence:12041069] NCBI Gene:11853 Rhoc [ReferenceDNASequence:11956976] Monarch:11853 Rhoc [ReferenceDNASequence:11869449] KEGG:mmu:11853 Rhoc [ReferenceDNASequence:11327187] BioGPS Gene:11853 Rhoc
referenceTranscript	[ReferenceRNASequence:12528203] RefSeq:NM_001291859.1 Rhoc [ReferenceRNASequence:12528202] RefSeq:NM_007484.2 Rhoc
schemaClass	ReferenceGeneProduct
secondaryIdentifier	RHOC_MOUSE Q3TUN0
sequenceLength	193
species	[Species:48892] Mus musculus
stId	uniprot:Q62159
url	http://purl.uniprot.org/uniprot/Q62159

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