UniProt:Q61982 Notch3

chain
  • signal peptide:1-39
  • chain:40-2318
  • chain:1630-2318
  • chain:1663-2318
checksum A80D1F75AFF0185A
comment
  • FUNCTION Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development.SUBUNIT Interacts with PSMA1 (By similarity). Heterodimer of a C-terminal fragment N(TM) and a N-terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH3. Interacts with HIF1AN.INTERACTION Following proteolytical processing NICD is translocated to the nucleus.TISSUE SPECIFICITY Proliferating neuroepithelium.DEVELOPMENTAL STAGE CNS development.DOMAIN The EGF-like domains 10 and 11 are required for binding the ligands JAG1 and DLL1.PTM Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C-terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane.PTM Phosphorylated.PTM Hydroxylated by HIF1AN.SIMILARITY Belongs to the NOTCH family.
crossReference
databaseName UniProt
dbId 96671
description
  • recommendedName: Neurogenic locus notch homolog protein 3 shortName: Notch 3 component recommendedName: Notch 3 extracellular truncation /component component recommendedName: Notch 3 intracellular domain /component
displayName UniProt:Q61982 Notch3
geneName
  • Notch3
identifier Q61982
isSequenceChanged false
keyword
  • Activator
  • ANK repeat
  • Cell membrane
  • Developmental protein
  • Differentiation
  • Disulfide bond
  • EGF-like domain
  • Glycoprotein
  • Membrane
  • Methylation
  • Notch signaling pathway
  • Nucleus
  • Phosphoprotein
  • Receptor
  • Reference proteome
  • Repeat
  • Signal
  • Transcription
  • Transcription regulation
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • Notch3
otherIdentifier
  • 10449775
  • 1421964_at
  • 1421965_s_at
  • 17343299
  • 18131
  • 4329560
  • 4339568
  • 4347879
  • 4363685
  • 4382468
  • 4433208
  • 4486332
  • 4557988
  • 4611451
  • 4636892
  • 4691356
  • 4705651
  • 4726022
  • 4746935
  • 4750175
  • 4769329
  • 4774093
  • 4778983
  • 4792678
  • 4825733
  • 4847929
  • 4867679
  • 4869687
  • 4875015
  • 4896786
  • 4944920
  • 4953578
  • 4960515
  • 5048573
  • 5062777
  • 5066042
  • 5073109
  • 5167748
  • 5177603
  • 5191342
  • 5239342
  • 5242775
  • 5275861
  • 5326475
  • 5329176
  • 5329587
  • 5365502
  • 5395696
  • 5445863
  • 5607152
  • 92956_at
  • A_51_P220162
  • A_55_P2856510
  • GO:0000122
  • GO:0005509
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005829
  • GO:0005886
  • GO:0006355
  • GO:0007219
  • GO:0007275
  • GO:0007411
  • GO:0008284
  • GO:0009986
  • GO:0010558
  • GO:0014016
  • GO:0016020
  • GO:0019899
  • GO:0030154
  • GO:0030182
  • GO:0030900
  • GO:0038023
  • GO:0042802
  • GO:0043235
  • GO:0045596
  • GO:0045665
  • GO:0045944
  • GO:0048661
  • GO:0048663
  • GO:0048844
  • GO:0048856
  • GO:0050793
  • GO:0072104
  • GO:1902895
  • ILMN_2697380
  • X74760_s_at
  • mMC008201
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NOTC3_MOUSE
sequenceLength 2318
species [Species:48892] Mus musculus
stId uniprot:Q61982
url http://purl.uniprot.org/uniprot/Q61982

Referrals

(referenceEntity)
(referenceSequence)
Cite Us!