UniProt:Q61827 Mafk

chain
  • chain:1-156
checksum 39F98F8A257F46CB
comment
  • FUNCTION Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (By similarity). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:9240432). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (By similarity).SUBUNIT Homodimer or heterodimer (By similarity). It can form high affinity heterodimers with members of the CNC-bZIP family such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3 (PubMed:9240432).INTERACTION Highly expressed in heart, skeletal muscle and placenta. Also expressed in erythroid cells.SIMILARITY Belongs to the bZIP family. Maf subfamily.
crossReference
databaseName UniProt
dbId 94827
description
  • recommendedName: Transcription factor MafK alternativeName: Erythroid transcription factor NF-E2 p18 subunit
displayName UniProt:Q61827 Mafk
geneName
  • Mafk
  • Nfe2u
identifier Q61827
isSequenceChanged false
keyword
  • DNA-binding
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
  • Ubl conjugation
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • Mafk
otherIdentifier
  • 102919_at
  • 10526961
  • 1418616_at
  • 17135
  • 17444037
  • 4593198
  • 4905266
  • 4933245
  • 4947126
  • 4967939
  • 5020678
  • 5268562
  • 5372619
  • 5508778
  • 5599081
  • A_51_P306183
  • A_55_P1953241
  • GE35712
  • GO:0000122
  • GO:0000976
  • GO:0000978
  • GO:0000981
  • GO:0001227
  • GO:0003677
  • GO:0003700
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0006355
  • GO:0006357
  • GO:0043565
  • ILMN_2683831
  • d42124_s_at
  • mMC003011
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • MAFK_MOUSE
  • Q60600
sequenceLength 156
species [Species:48892] Mus musculus
stId uniprot:Q61827
url http://purl.uniprot.org/uniprot/Q61827
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