Reactome | UniProt:Q61140 Bcar1

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UniProt:Q61140 Bcar1 Show undefined attributes

chain	chain:1-874
checksum	81E56BC7AD87B095
comment	FUNCTION Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (By similarity). Implicated in induction of cell migration and cell branching (PubMed:25499443). Involved in the BCAR3-mediated inhibition of TGFB signaling (PubMed:25499443).SUBUNIT Forms complexes in vivo with PTK2/FAK1, adapter protein CRKL and LYN kinase. Can heterodimerize with NEDD9. Component of a complex comprised of SH2D3C, BCAR1/CAS, and CRK (By similarity). Within the complex, interacts with SH2D3C (via C-terminus), and CRK (By similarity). Part of a complex comprised of PTPRA, BCAR1, BCAR3 (via SH2 domain) and SRC; the formation of the complex is dependent on integrin mediated-tyrosine phosphorylation of PTPRA (PubMed:22801373). Interacts with BCAR3 (via Ras-GEF domain); the interaction regulates adhesion-dependent serine phosphorylation (PubMed:10896938, PubMed:22801373). Interacts with SMAD2 and SMAD3 (PubMed:25499443). Interacts with NPHP1 (PubMed:10739664). Interacts with PTK2B/PYK2 (By similarity). Interacts (via C-terminus) with SH2D3C/CHAT isoform 2 (via C-terminus) (PubMed:10692442, PubMed:12486027, PubMed:17174122). Interacts with activated CSPG4. Interacts with BMX, INPPL1/SHIP2 and PEAK1 (By similarity). Part of a collagen stimulated complex involved in cell migration composed of CDC42, CRK, TNK2 and BCAR1/p130cas (By similarity). Interacts with TNK2 via SH3 domains. Interacts (when tyrosine-phosphorylated) with tensin TNS1; the interaction is increased by phosphorylation of TNS1 (By similarity).INTERACTION Unphosphorylated form localizes in the cytoplasm (PubMed:22801373). Localizes to focal adhesion sites following integrin engagement (PubMed:22801373).ALTERNATIVE PRODUCTS Expressed in olfactory sensory neurons (at protein level) (PubMed:20881139). Expressed abundantly in the liver, lung, brain, and at lower levels in the heart (at protein level) (PubMed:19365570).DOMAIN Contains a central domain (substrate domain) containing multiple potential SH2-binding sites and a C-terminal domain containing a divergent helix-loop-helix (HLH) motif. The SH2-binding sites putatively bind CRK, NCK and ABL SH2 domains. The HLH motif is absolutely required for the induction of pseudohyphal growth in yeast and mediates heterodimerization with NEDD9.DOMAIN A serine-rich region promotes activation of the serum response element (SRE).DOMAIN The SH3 domain is necessary for the localization of the protein to focal adhesions and interacts with one proline-rich region of PTK2/FAK1.PTM PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix (By similarity).PTM Dephosphorylated by PTPN14 at Tyr-132.PTM Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner; phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway.SIMILARITY Belongs to the CAS family.
crossReference	[DatabaseIdentifier:12238169] PRO:Q61140 [DatabaseIdentifier:12308580] RefSeq:NP_001185768.1 [DatabaseIdentifier:12308581] RefSeq:NP_034084.2 [DatabaseIdentifier:11444252] ENSEMBL:ENSMUSG00000031955 [DatabaseIdentifier:11530549] ENSEMBL:ENSMUSP00000129584 [DatabaseIdentifier:11530550] ENSEMBL:ENSMUSP00000148364 [DatabaseIdentifier:11653248] ENSEMBL:ENSMUST00000212349 [DatabaseIdentifier:11653249] ENSEMBL:ENSMUST00000166232 [DatabaseIdentifier:11928956] MGI:108091 [DatabaseIdentifier:12149852] PDB:5W93
databaseName	UniProt
dbId	85832
description	recommendedName: Breast cancer anti-estrogen resistance protein 1 alternativeName: CRK-associated substrate alternativeName: p130cas
displayName	UniProt:Q61140 Bcar1
geneName	Bcar1 Cas Crkas
identifier	Q61140
isSequenceChanged	false
keyword	3D-structure Acetylation Alternative splicing Cell adhesion Cell junction Cell projection Cytoplasm Phosphoprotein Reference proteome SH3 domain SH3-binding
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	Bcar1
otherIdentifier	10581890 12927 1439388_s_at 1450622_at 17513158 4390000 4419546 4521517 4538448 4541694 4833977 4856333 5245279 5380153 5444465 5596444 98990_at A_51_P375227 A_55_P2056639 GE35258 GO:0001726 GO:0002376 GO:0005515 GO:0005737 GO:0005829 GO:0005856 GO:0005886 GO:0005925 GO:0007015 GO:0007155 GO:0007169 GO:0007173 GO:0007186 GO:0007229 GO:0008286 GO:0010595 GO:0015629 GO:0016020 GO:0016477 GO:0017124 GO:0019901 GO:0030027 GO:0030335 GO:0030424 GO:0035729 GO:0042995 GO:0048008 GO:0048010 GO:0048011 GO:0048012 GO:0048870 GO:0050851 GO:0050853 GO:0060326 GO:0070161 GO:0086100 ILMN_2743133 mMC010251 u28151_s_at
physicalEntity	[EntityWithAccessionedSequence:R-MMU-201625] Bcar1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-8848723] phospho-Bcar1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5218739] phospho-Bcar1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5218743] p130Cas [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5218727] p-12Y-P130Cas [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-MMU-372645] phospho-Bcar1 [cytosol] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:11309875] BioGPS Gene:12927 Bcar1 [ReferenceDNASequence:12669613] UCSC:Q61140 Bcar1 [ReferenceDNASequence:11853600] KEGG:mmu:12927 Bcar1 [ReferenceDNASequence:11939664] Monarch:12927 Bcar1 [ReferenceDNASequence:12023757] NCBI Gene:12927 Bcar1
referenceTranscript	[ReferenceRNASequence:12490689] RefSeq:NM_009954.3 Bcar1 [ReferenceRNASequence:12490688] RefSeq:NM_001198839.1 Bcar1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	BCAR1_MOUSE Q60869 Q6PFF9
sequenceLength	874
species	[Species:48892] Mus musculus
stId	uniprot:Q61140
url	http://purl.uniprot.org/uniprot/Q61140

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-MMU-201625] Bcar1 [cytosol] [EntityWithAccessionedSequence:R-MMU-8848723] phospho-Bcar1 [cytosol] [EntityWithAccessionedSequence:R-MMU-5218739] phospho-Bcar1 [cytosol] [EntityWithAccessionedSequence:R-MMU-5218743] p130Cas [cytosol] [EntityWithAccessionedSequence:R-MMU-5218727] p-12Y-P130Cas [cytosol] [EntityWithAccessionedSequence:R-MMU-372645] phospho-Bcar1 [cytosol]
(referenceSequence)	[ModifiedResidue:10052859] O4'-phospho-L-tyrosine at 664 (in Homo sapiens) [ModifiedResidue:10075132] O4'-phospho-L-tyrosine at 165 (in Homo sapiens) [ModifiedResidue:10052857] O4'-phospho-L-tyrosine at 387 (in Homo sapiens) [ModifiedResidue:10052856] O4'-phospho-L-tyrosine at 372 (in Homo sapiens) [ModifiedResidue:10052858] O4'-phospho-L-tyrosine at 410 (in Homo sapiens) [ModifiedResidue:10052860] O4'-phospho-L-tyrosine at 666 (in Homo sapiens) [ModifiedResidue:10052849] O4'-phospho-L-tyrosine at 234 (in Homo sapiens) [ModifiedResidue:10052851] O4'-phospho-L-tyrosine at 267 (in Homo sapiens) [ModifiedResidue:10052850] O4'-phospho-L-tyrosine at 249 (in Homo sapiens) [ModifiedResidue:10052853] O4'-phospho-L-tyrosine at 306 (in Homo sapiens) [ModifiedResidue:10052852] O4'-phospho-L-tyrosine at 287 (in Homo sapiens) [ModifiedResidue:10052855] O4'-phospho-L-tyrosine at 362 (in Homo sapiens) [ModifiedResidue:10052854] O4'-phospho-L-tyrosine at 327 (in Homo sapiens) [ModifiedResidue:5218703] O4'-phospho-L-tyrosine at 366 [ModifiedResidue:5218719] O4'-phospho-L-tyrosine at 668 [ModifiedResidue:5218702] O4'-phospho-L-tyrosine at 271 [ModifiedResidue:5218718] O4'-phospho-L-tyrosine at 310 [ModifiedResidue:5218750] O4'-phospho-L-tyrosine at 414 [ModifiedResidue:5218729] O4'-phospho-L-tyrosine at 253 [ModifiedResidue:5218713] O4'-phospho-L-tyrosine at 291 [ModifiedResidue:5218741] O4'-phospho-L-tyrosine at 391 [ModifiedResidue:5218724] O4'-phospho-L-tyrosine at 238 [ModifiedResidue:5218740] O4'-phospho-L-tyrosine at 331 [ModifiedResidue:5218691] O4'-phospho-L-tyrosine at 670 [ModifiedResidue:5218737] O4'-phospho-L-tyrosine at 376 [ModifiedResidue:10008443] O4'-phospho-L-tyrosine at unknown position
(interactor)	[UndirectedInteraction:11207853] UniProt:P18031 <-> UniProt:Q61140 (IntAct) [UndirectedInteraction:11264087] UniProt:Q61140 <-> UniProt:P34152 (IntAct) [UndirectedInteraction:11264089] UniProt:Q61140 <-> UniProt:Q9QY53 (IntAct) [UndirectedInteraction:11264091] UniProt:Q61140 <-> UniProt:P97333 (IntAct)