Reactome | UniProt:Q61115 Ptch1

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UniProt:Q61115 Ptch1 Show undefined attributes

chain	chain:1-1434
checksum	A5E9189E633173D0
comment	FUNCTION Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.SUBUNIT Interacts with SNX17 (By similarity). Interacts with IHH (PubMed:21537345). Interacts with G-protein coupled receptor GPR37L1 (PubMed:24062445).INTERACTION Detected in cerebellar Bergmann glia cells (at protein level) (PubMed:24062445). In the developing embryo, first detected within the ventral neural tube and later in the somites and limb buds (PubMed:8595881). Expression in the limb buds is restricted to the posterior ectoderm surrounding the zone of polarizing activity (PubMed:8595881). In the adult, expression is seen in brain, lung, liver, kidney and ocular tissues; lower levels in heart, skeletal muscle, and testis (PubMed:8595881).DEVELOPMENTAL STAGE Expressed at very low levels at 7 dpc, is most strongly expressed between 11 and 15 dpc, and persists at moderate levels at 17 dpc (PubMed:8595881). Also expressed in the adult (PubMed:8595881).INDUCTION Activated by Sonic hedgehog.PTM Glycosylation is necessary for SHH binding.PTM In the absence of Hh ligands, ubiquitination by ITCH at Lys-1413 promotes endocytosis and both proteasomal and lysosomal degradation.SIMILARITY Belongs to the patched family.
crossReference	[DatabaseIdentifier:12311121] RefSeq:NP_032983.1 [DatabaseIdentifier:12239550] PRO:Q61115 [DatabaseIdentifier:12155188] PDB:7K65 [DatabaseIdentifier:12155187] PDB:7V6Y [DatabaseIdentifier:12155189] PDB:7V6Z [DatabaseIdentifier:12155186] PDB:6MG8 [DatabaseIdentifier:11929897] MGI:105373 [DatabaseIdentifier:11799558] GlyGen:Q61115 [DatabaseIdentifier:11654961] ENSEMBL:ENSMUST00000021921 [DatabaseIdentifier:11532262] ENSEMBL:ENSMUSP00000021921 [DatabaseIdentifier:11445420] ENSEMBL:ENSMUSG00000021466
databaseName	UniProt
dbId	99210
description	recommendedName: Protein patched homolog 1 shortName: PTC shortName: PTC1
displayName	UniProt:Q61115 Ptch1
geneName	Ptch1 Ptch
identifier	Q61115
isSequenceChanged	false
keyword	3D-structure Cell membrane Glycoprotein Isopeptide bond Membrane Phosphoprotein Receptor Reference proteome Transmembrane Transmembrane helix Ubl conjugation
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	Ptch1
otherIdentifier	104030_at 104031_at 10410039 109521_at 1428853_at 1439663_at 1450824_at 17293607 19206 4310638 4362973 4409610 4420646 4428601 4479619 4483536 4487706 4510017 4516447 4518239 4535511 4542871 4560337 4574021 4597258 4605241 4635359 4670119 4705538 4714760 4723905 4749419 4767872 4769716 4811029 4838385 4877429 4887438 4932545 4956509 5028325 5057091 5109885 5117303 5185290 5202176 5241256 5252462 5264332 5348289 5374840 5379674 5400658 5409897 5423481 5495994 5522428 5569209 A_51_P127435 A_52_P598605 A_52_P763309 A_52_P78168 A_55_P2107292 A_55_P2741038 A_65_P18909 GE1508895 GE1560060 GE34284 GO:0000122 GO:0001658 GO:0001701 GO:0001709 GO:0001841 GO:0001843 GO:0003007 GO:0005113 GO:0005119 GO:0005515 GO:0005576 GO:0005794 GO:0005886 GO:0005901 GO:0005929 GO:0006355 GO:0007165 GO:0007286 GO:0007346 GO:0007389 GO:0007420 GO:0008158 GO:0008201 GO:0008270 GO:0008285 GO:0008289 GO:0008544 GO:0009410 GO:0009612 GO:0009887 GO:0009953 GO:0009957 GO:0010157 GO:0010839 GO:0010875 GO:0015485 GO:0016020 GO:0016485 GO:0021522 GO:0021532 GO:0021904 GO:0021997 GO:0022414 GO:0030154 GO:0030326 GO:0030332 GO:0030496 GO:0030850 GO:0030879 GO:0032355 GO:0032526 GO:0032880 GO:0035108 GO:0035137 GO:0040008 GO:0040015 GO:0042127 GO:0042593 GO:0043226 GO:0043279 GO:0043616 GO:0044294 GO:0044295 GO:0044877 GO:0045177 GO:0045211 GO:0045606 GO:0045668 GO:0045879 GO:0045892 GO:0045893 GO:0048471 GO:0048568 GO:0048745 GO:0048856 GO:0050673 GO:0050680 GO:0051782 GO:0060037 GO:0060603 GO:0060644 GO:0061005 GO:0061053 GO:0071397 GO:0071679 GO:0072089 GO:0072203 GO:0072205 GO:0072659 GO:0097108 GO:0097421 GO:2000647 ILMN_1248463 ILMN_2460224 Msa.2054.0_s_at mMC015162 mMR028684
physicalEntity	[EntityWithAccessionedSequence:R-MMU-5632520] Ptch1 [endocytic vesicle membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5632516] ub Ptch1 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-517520] Patched homolog 1 [plasma membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5610415] Ptch1 [ciliary membrane] - Mus musculus [EntityWithAccessionedSequence:R-MMU-5632517] Ptch1 [ciliary membrane] - Mus musculus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12670345] UCSC:Q61115 Ptch1 [ReferenceDNASequence:12024971] NCBI Gene:19206 Ptch1 [ReferenceDNASequence:11940878] Monarch:19206 Ptch1 [ReferenceDNASequence:11854761] KEGG:mmu:19206 Ptch1 [ReferenceDNASequence:11311089] BioGPS Gene:19206 Ptch1
referenceTranscript	[ReferenceRNASequence:12493202] RefSeq:NM_008957.3 Ptch1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PTC1_MOUSE
sequenceLength	1434
species	[Species:48892] Mus musculus
stId	uniprot:Q61115
url	http://purl.uniprot.org/uniprot/Q61115

Referrals

(interactor)	[UndirectedInteraction:11295775] UniProt:Q61115 <-> UniProt:Q96EY1 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-MMU-5632520] Ptch1 [endocytic vesicle membrane] [EntityWithAccessionedSequence:R-MMU-5632516] ub Ptch1 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-517520] Patched homolog 1 [plasma membrane] [EntityWithAccessionedSequence:R-MMU-5610415] Ptch1 [ciliary membrane] [EntityWithAccessionedSequence:R-MMU-5632517] Ptch1 [ciliary membrane]
(referenceSequence)	[ModifiedResidue:5632469] ubiquitinylated lysine at unknown position

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