UniProt:Q60770 Stxbp3

chain
  • chain:1-592
checksum 7874B71DE107871A
comment
  • FUNCTION Together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes.SUBUNIT Interacts with STX4. Interacts with DOC2B; the interaction is direct, occurs at the cell membrane, excludes interaction with STX4 and regulates glucose-stimulated insulin secretion.INTERACTION In platelets, predominantly cytosolic. Low amounts membrane-associated (By similarity).ALTERNATIVE PRODUCTS Ubiquitously expressed in all tissues tested.PTM Phosphorylated by PKC in platelets in response to thrombin stimulation; phosphorylation inhibits binding to STX4.SIMILARITY Belongs to the STXBP/unc-18/SEC1 family.
crossReference
databaseName UniProt
dbId 102411
description
  • recommendedName: Syntaxin-binding protein 3 alternativeName: MUNC-18-3 alternativeName: Mammalian homolog of Unc-18c shortName: Munc-18c alternativeName: Protein unc-18 homolog 3 shortName: Unc18-3 alternativeName: Protein unc-18 homolog C shortName: Unc-18C
displayName UniProt:Q60770 Stxbp3
geneName
  • Stxbp3
  • Stxbp3a
  • Unc18c
identifier Q60770
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell membrane
  • Cytoplasm
  • Membrane
  • Phosphoprotein
  • Protein transport
  • Reference proteome
  • Transport
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • Stxbp3
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • STXB3_MOUSE
  • Q3TE73
  • Q3U2S2
  • Q3U8D9
  • Q3UA91
  • Q3UUB0
sequenceLength 592
species [Species:48892] Mus musculus
stId uniprot:Q60770
url http://purl.uniprot.org/uniprot/Q60770
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