UniProt:Q60692 Psmb6

chain
  • initiator methionine:1
  • propeptide:2-33
  • chain:34-238
checksum 5A4EB82C4374C6FE
comment
  • FUNCTION Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB6 displays a peptidylglutamyl-hydrolyzing activity also termed postacidic or caspase-like activity, meaning that the peptides bond hydrolysis occurs directly after acidic residues.CATALYTIC ACTIVITY Cleavage of peptide bonds with very broad specificity.SUBUNIT The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7.SUBCELLULAR LOCATION Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9.INDUCTION Up-regulated by the antioxidant dithiolethione (D3T) in liver, lung and small intestine (at protein level).SIMILARITY Belongs to the peptidase T1B family.
crossReference
databaseName UniProt
dbId 99074
description
  • recommendedName: Proteasome subunit beta type-6 ecNumber evidence="2"3.4.25.1 alternativeName: Low molecular mass protein 19 alternativeName: Macropain delta chain alternativeName: Multicatalytic endopeptidase complex delta chain alternativeName: Proteasome delta chain alternativeName: Proteasome subunit Y alternativeName: Proteasome subunit beta-1 shortName: beta-1
displayName UniProt:Q60692 Psmb6
geneName
  • Psmb6
  • Lmp19
identifier Q60692
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Cytoplasm
  • Direct protein sequencing
  • Hydrolase
  • Nucleus
  • Phosphoprotein
  • Protease
  • Proteasome
  • Reference proteome
  • Threonine protease
  • Zymogen
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • Psmb6
otherIdentifier
  • 101992_at
  • 10377851
  • 1448822_at
  • 17252070
  • 19175
  • 4419701
  • 4525825
  • 4567677
  • 4679562
  • 4760580
  • 4989009
  • 4993272
  • 5120461
  • 5182984
  • 5189731
  • 5259452
  • 5337066
  • 5443190
  • A_52_P199375
  • A_55_P2035657
  • GE34278
  • GO:0000502
  • GO:0004175
  • GO:0004298
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0005739
  • GO:0005829
  • GO:0005839
  • GO:0006508
  • GO:0008233
  • GO:0016787
  • GO:0019774
  • GO:0030163
  • GO:0043161
  • GO:0051603
  • ILMN_2777337
  • mMC019276
  • u13393_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PSB6_MOUSE
  • Q3V240
  • Q60693
  • Q8BJX9
  • Q91VH5
sequenceLength 238
species [Species:48892] Mus musculus
stId uniprot:Q60692
url http://purl.uniprot.org/uniprot/Q60692
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