UniProt:Q5XXA6 ANO1

chain
  • chain:1-986
checksum E30A02F91EF36FC2
comment
  • FUNCTION Calcium-activated chloride channel (CaCC) (PubMed:20056604, PubMed:22178883, PubMed:22946059, PubMed:32487539). Plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development. Required for CFTR activation by enhancing endoplasmic reticulum Ca(2+) store release and is also required for CFTR membrane expression (PubMed:28963502). Required for basal and ATP-dependent mucus secretion in airways and intestine, probably by controlling exocytosis of mucus-filled granules by providing Ca(2+) to an apical signaling compartment (By similarity). Contributes to airway mucus expression induced by interleukins IL3 and IL8 and by the asthma-associated protein CLCA1 and is required for expression of mucin MUC5AC (PubMed:33026825). However, was shown in another study not to be required for MUC5AC expression (PubMed:31732694). Plays a role in the propagation of Ca(2+) waves in Kolliker's organ in the cochlea and contributes to the refinement of auditory brainstem circuitries prior to hearing onset (By similarity). In vomeronasal sensory neurons, modulates spontaneous firing patterns in the absence of stimuli as well as the firing pattern of pheromone-evoked activity (By similarity). Responsible for calcium-activated chloride channel activity in type I taste cells of the vallate papillae (By similarity). Acts as a heat sensor in nociceptive neurons (By similarity). In dorsal root ganglion neurons, plays a role in mediating non-histaminergic Mas-related G-protein coupled receptor (MRGPR)-dependent itching, acting as a downstream effector of MRGPRs (By similarity). In the developing brain, required for the Ca(2+)-dependent process extension of radial glial cells (By similarity).FUNCTION Calcium-activated chloride channel (CaCC). Contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Shows increased basal chloride permeability and decreased Ca(2+)-induced chloride permeability.FUNCTION Calcium-activated chloride channel (CaCC). Shows increased sensitivity to intracellular Ca(2+).CATALYTIC ACTIVITY chloride(in) = chloride(out)ACTIVITY REGULATION ATP and calmodulin are essential for its activation. Channel activity is inhibited by CFTR protein and by chloride inhibitors such as niflumic acid (NFA) and 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Activated by heat with activation seen at temperatures above 44 degrees Celsius (By similarity). Activated by BDNF in radial glial cells (By similarity).SUBUNIT Homodimer (PubMed:21056985, PubMed:28559167). Interacts with CFTR (PubMed:22178883, PubMed:28963502). Interacts with TRPV4 (By similarity).SUBCELLULAR LOCATION In differentiating airway epithelial cells, predominantly intracellular at day 0 but is apically localized by day 30. Expressed in the presynapse of retinal neurons (By similarity).ALTERNATIVE PRODUCTS Expressed in nasal epithelial cells (at protein level) (PubMed:32487539). In the kidney, expressed in the collecting duct (at protein level) (PubMed:24913262). Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles (PubMed:15215166, PubMed:16906560). Expressed in eccrine sweat glands (PubMed:25220078).DEVELOPMENTAL STAGE In airway epithelial cells, highly expressed during cell proliferation with levels decreasing as cell differentiation progresses (at protein level).INDUCTION By IL13 (PubMed:33026825). By IL4, likely as a result of IL4-induced cell proliferation (PubMed:31732694). By wounding in airway epithelial cells with levels decreasing significantly during the healing process (PubMed:31732694).DOMAIN The region spanning the fifth and sixth transmembrane domains probably forms the pore-forming region.DISEASE The disease may be caused by variants affecting the gene represented in this entry.DISEASE The disease may be caused by variants affecting the gene represented in this entry.MISCELLANEOUS The term 'anoctamin' was coined because these channels are anion selective and are predicted to have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.SIMILARITY Belongs to the anoctamin family.CAUTION Contains ten transmembrane regions, not eight as predicted.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 251585
description
  • recommendedName: Anoctamin-1 alternativeName: Discovered on gastrointestinal stromal tumors protein 1 alternativeName: Oral cancer overexpressed protein 2 alternativeName: Transmembrane protein 16A alternativeName: Tumor-amplified and overexpressed sequence 2
displayName UniProt:Q5XXA6 ANO1
geneName
  • ANO1
  • DOG1
  • ORAOV2
  • TAOS2
  • TMEM16A
identifier Q5XXA6
isSequenceChanged false
keyword
  • Alternative splicing
  • Calcium
  • Cell membrane
  • Cell projection
  • Chloride
  • Chloride channel
  • Developmental protein
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Ion channel
  • Ion transport
  • Membrane
  • Metal-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Synapse
  • Transmembrane
  • Transmembrane helix
  • Transport
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • ANO1
otherIdentifier
  • 11723828_a_at
  • 11723829_s_at
  • 11723830_x_at
  • 1555269_PM_a_at
  • 1555269_a_at
  • 16728287
  • 218804_PM_at
  • 218804_at
  • 3338301
  • 3338302
  • 3338303
  • 3338320
  • 3338321
  • 3338322
  • 3338323
  • 3338324
  • 3338325
  • 3338326
  • 3338327
  • 3338336
  • 3338337
  • 3338339
  • 3338340
  • 3338341
  • 3338343
  • 3338344
  • 3338345
  • 3338346
  • 3338347
  • 3338349
  • 3338350
  • 3338352
  • 3338355
  • 3338360
  • 3338361
  • 3338363
  • 3338366
  • 3338367
  • 3338368
  • 3338369
  • 3338370
  • 3338371
  • 3338372
  • 3338374
  • 3338375
  • 3338379
  • 3338380
  • 3338381
  • 3338383
  • 3338384
  • 3338386
  • 3338387
  • 3338388
  • 3338389
  • 3338390
  • 3338391
  • 43366_at
  • 43963_at
  • 55107
  • 7942135
  • A_14_P128437
  • A_23_P98304
  • A_24_P110831
  • A_24_P87036
  • A_33_P3381292
  • GE82285
  • GO:0005102
  • GO:0005227
  • GO:0005229
  • GO:0005247
  • GO:0005254
  • GO:0005515
  • GO:0005654
  • GO:0005886
  • GO:0006811
  • GO:0006821
  • GO:0007200
  • GO:0015111
  • GO:0015705
  • GO:0016020
  • GO:0016324
  • GO:0034220
  • GO:0034605
  • GO:0034707
  • GO:0042802
  • GO:0042803
  • GO:0042995
  • GO:0045202
  • GO:0046872
  • GO:0046983
  • GO:0050965
  • GO:0055085
  • GO:0070062
  • GO:0070254
  • GO:0072657
  • GO:0098655
  • GO:0098793
  • GO:0106091
  • GO:1901653
  • GO:1902476
  • HMNXSV003008747
  • HMNXSV003008768
  • HMNXSV003019302
  • Hs2.26176.2.S1_3p_s_at
  • ILMN_1717909
  • ILMN_2091310
  • PH_hs_0040955
  • TC11000721.hg
  • TC11002761.hg
  • g8922319_3p_at
  • p33664
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ANO1_HUMAN
  • A0A2H4Y9B2
  • A8KAM3
  • E9PNA7
  • Q8IYY8
  • Q8N7V3
sequenceLength 986
species [Species:48887] Homo sapiens
stId uniprot:Q5XXA6
url http://purl.uniprot.org/uniprot/Q5XXA6
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