UniProt:Q5VZM2 RRAGB

chain
  • chain:1-374
checksum 0D32F7D86E2A00DE
comment
  • FUNCTION Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). Forms heterodimeric Rag complexes with RagC/RRAGC or RagD/RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form: RagB/RRAGB is in its active form when GTP-bound RagB/RRAGB forms a complex with GDP-bound RagC/RRAGC (or RagD/RRAGD) and in an inactive form when GDP-bound RagB/RRAGB heterodimerizes with GTP-bound RagC/RRAGC (or RagD/RRAGD) (PubMed:18497260, PubMed:20381137, PubMed:23723238, PubMed:24095279). In its GTP-bound active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB (PubMed:18497260, PubMed:20381137, PubMed:23723238). Involved in the RCC1/Ran-GTPase pathway (PubMed:9394008).CATALYTIC ACTIVITY GTP + H2O = GDP + phosphate + H(+)ACTIVITY REGULATION The activation of GTP-binding proteins is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP) (PubMed:22980980, PubMed:23723238). The Ragulator complex functions as a GEF and promotes the active GTP-bound form (PubMed:22980980). The GATOR1 complex functions as a GAP and stimulates RRAGB GTPase activity to turn it into its inactive GDP-bound form, preventing mTORC1 recruitment and activation (PubMed:23723238).SUBUNIT Interacts with RRAGC and RRAGD; heterodimerization stabilizes RRAG proteins (PubMed:11073942). The GTP-bound form of RRAGB (in complex with the GDP-bound form of RRAGC or RRAGD) interacts with RPTOR, thereby promoting recruitment of mTORC1 to the lysosomes (PubMed:18497260). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RagA/RRAGA or RagB/RRAGB GDP-bound, RagC/RRAGC or RagD/RRAGD GTP-bound, and Ragulator (By similarity). Interacts with SH3BP4; the interaction with this negative regulator is most probably direct, preferentially occurs with the inactive GDP-bound form of RRAGB, is negatively regulated by amino acids and prevents interaction with RPTOR (PubMed:22575674). Interacts with the GATOR1 complex; inactivates RRAGB (PubMed:23723238). The Rag heterodimer interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, PubMed:25567906). Interacts with SESN1, SESN2 and SESN3 (PubMed:25259925).INTERACTION Recruited to the lysosome surface by the Ragulator complex.ALTERNATIVE PRODUCTS Belongs to the GTR/RAG GTP-binding protein family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 246461
description
  • recommendedName: fullName evidence="21"Ras-related GTP-binding protein B shortName evidence="15"Rag B shortName evidence="19"RagB ecNumber evidence="8 22"3.6.5.-
displayName UniProt:Q5VZM2 RRAGB
geneName
  • RRAGB
identifier Q5VZM2
isSequenceChanged false
keyword
  • Acetylation
  • Alternative splicing
  • Cytoplasm
  • GTP-binding
  • Hydrolase
  • Isopeptide bond
  • Lysosome
  • Membrane
  • Nucleotide-binding
  • Proteomics identification
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • RRAGB
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RRAGB_HUMAN
  • A8K042
  • Q15348
  • Q8N3T0
sequenceLength 374
species [Species:48887] Homo sapiens
stId uniprot:Q5VZM2
url http://purl.uniprot.org/uniprot/Q5VZM2
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