Reactome | UniProt:Q5VWK5 IL23R

chain	signal peptide:1-23 chain:24-629
checksum	AC63C89E81AABF05
comment	FUNCTION Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.SUBUNIT Heterodimer with IL12RB1. In presence of IL23, the heterodimer forms the IL23 receptor. Interacts with JAK2 and in presence of IL23 with STAT3.INTERACTION Expressed by monocytes, Th1, Th0, NK and dendritic cells. Isoform 1 is specifically expressed in NK cells.PTM Phosphorylated in response to IL23.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.MISCELLANEOUS Produced by translation in an alternate frame of the cDNA encoding isoform 4.MISCELLANEOUS Produced by translation in an alternate frame of the cDNA encoding isoform 5.MISCELLANEOUS Produced by translation in an alternate frame of the cDNA encoding isoform 2.MISCELLANEOUS Produced by translation in an alternate frame of the cDNA encoding isoform 3.SIMILARITY Belongs to the type I cytokine receptor family. Type 2 subfamily.SEQUENCE CAUTION Extended N-terminus.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:12418674] RefSeq:XP_054190613.1 [DatabaseIdentifier:12418677] RefSeq:XP_011539093.1 [DatabaseIdentifier:12418676] RefSeq:NP_653302.2 [DatabaseIdentifier:12418673] RefSeq:XP_054190614.1 [DatabaseIdentifier:12418675] RefSeq:XP_011539092.1 [DatabaseIdentifier:11495130] ENSEMBL:ENSG00000162594 [DatabaseIdentifier:11603171] ENSEMBL:ENSP00000387640 [DatabaseIdentifier:11603174] ENSEMBL:ENSP00000513139 [DatabaseIdentifier:11603173] ENSEMBL:ENSP00000513138 [DatabaseIdentifier:11603172] ENSEMBL:ENSP00000513142 [DatabaseIdentifier:11603170] ENSEMBL:ENSP00000513140 [DatabaseIdentifier:11603176] ENSEMBL:ENSP00000513191 [DatabaseIdentifier:11603175] ENSEMBL:ENSP00000513190 [DatabaseIdentifier:11603177] ENSEMBL:ENSP00000321345 [DatabaseIdentifier:11725869] ENSEMBL:ENST00000697150 [DatabaseIdentifier:11725871] ENSEMBL:ENST00000697149 [DatabaseIdentifier:11725870] ENSEMBL:ENST00000697151 [DatabaseIdentifier:11725872] ENSEMBL:ENST00000697224 [DatabaseIdentifier:11725873] ENSEMBL:ENST00000425614 [DatabaseIdentifier:11725874] ENSEMBL:ENST00000347310 [DatabaseIdentifier:11725876] ENSEMBL:ENST00000697153 [DatabaseIdentifier:11725875] ENSEMBL:ENST00000697223 [DatabaseIdentifier:11778937] Guide to Pharmacology - Targets:1717 [DatabaseIdentifier:11789500] GeneCards:IL23R [DatabaseIdentifier:11805131] GlyGen:Q5VWK5 [DatabaseIdentifier:11842527] HPA:ENSG00000162594-IL23R [DatabaseIdentifier:12127119] OpenTargets:ENSG00000162594 [DatabaseIdentifier:12134995] Orphanet:IL23R [DatabaseIdentifier:12190138] PDB:9MFG [DatabaseIdentifier:12154441] PDB:8OE4 [DatabaseIdentifier:12154439] PDB:6WDQ [DatabaseIdentifier:12190137] PDB:5MZV [DatabaseIdentifier:12247595] PRO:Q5VWK5 [DatabaseIdentifier:12287361] Pharos - Targets:Q5VWK5
databaseName	UniProt
dbId	232652
description	recommendedName: Interleukin-23 receptor shortName: IL-23 receptor shortName: IL-23R
displayName	UniProt:Q5VWK5 IL23R
geneName	IL23R
identifier	Q5VWK5
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Glycoprotein Immunity Inflammatory response Innate immunity Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Repeat Signal Transmembrane Transmembrane helix
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	IL23R
otherIdentifier	11737362_x_at 11748794_a_at 149233 1552912_3p_a_at 1552912_PM_a_at 1552912_a_at 1561853_PM_a_at 1561853_a_at 16665878 2340933 2340934 2340935 2340936 2340937 2340939 2340941 2340943 2340944 2340947 2340948 2340951 2340952 2340953 2340954 2340955 2340956 2340957 2340958 7902189 A_14_P135991 A_23_P425197 GE599987 GO:0001916 GO:0002230 GO:0002376 GO:0002827 GO:0004896 GO:0004925 GO:0005143 GO:0005515 GO:0005886 GO:0006954 GO:0007259 GO:0008284 GO:0009897 GO:0009986 GO:0016020 GO:0017046 GO:0019221 GO:0019955 GO:0032496 GO:0032693 GO:0032725 GO:0032729 GO:0032735 GO:0032740 GO:0032819 GO:0034341 GO:0038155 GO:0038161 GO:0042019 GO:0042020 GO:0042102 GO:0042104 GO:0043235 GO:0043382 GO:0045087 GO:0045672 GO:0050829 GO:0051135 GO:0072536 GO:0097696 GO:0098542 GO:2000318 GO:2000330 HMNXSV003000736 Hs2.375184.3.S1_3p_a_at ILMN_1734937 ILMN_2223663 PH_hs_0018226 TC01000739.hg TC01004453.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-447156] IL23R [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8950616] p-Y-IL23R [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000162594] ENSEMBL:ENSG00000162594 IL23R [ReferenceDNASequence:12753169] UCSC:Q5VWK5 IL23R [ReferenceDNASequence:11360807] BioGPS Gene:149233 IL23R [ReferenceDNASequence:11401809] COSMIC - genes:IL23R IL23R [ReferenceDNASequence:11416221] CTD Gene:149233 IL23R [ReferenceDNASequence:11439205] dbSNP Gene:149233 IL23R [ReferenceDNASequence:11821156] HGNC:19100 IL23R [ReferenceDNASequence:11899831] KEGG:hsa:149233 IL23R [ReferenceDNASequence:11990596] Monarch:149233 IL23R [ReferenceDNASequence:12074689] NCBI Gene:149233 IL23R [ReferenceDNASequence:12112029] OMIM:607562 IL23R
referenceTranscript	[ReferenceRNASequence:12600338] RefSeq:XM_054334638.1 IL23R [ReferenceRNASequence:12600337] RefSeq:NM_144701.2 IL23R [ReferenceRNASequence:12600336] RefSeq:XM_054334639.1 IL23R [ReferenceRNASequence:12600334] RefSeq:XM_011540790.4 IL23R [ReferenceRNASequence:12600335] RefSeq:XM_011540791.4 IL23R
schemaClass	ReferenceGeneProduct
secondaryIdentifier	IL23R_HUMAN C9JGX4 Q4VGP1 Q4VGP2 Q4VGP3 Q4VGP4 Q4VGP5 Q4VGP6 Q5VWK7 Q8IW84 Q8NFQ9 Q96AS1
sequenceLength	629
species	[Species:48887] Homo sapiens
stId	uniprot:Q5VWK5
url	http://purl.uniprot.org/uniprot/Q5VWK5

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-447156] IL23R [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8950616] p-Y-IL23R [plasma membrane]
(referenceSequence)	[ModifiedResidue:8950734] O4'-phospho-L-tyrosine at unknown position
(interactor)	[UndirectedInteraction:11155793] UniProt:Q5VWK5 <-> IntAct:EBI-9992716 (IntAct) [UndirectedInteraction:11155795] UniProt:Q5VWK5 <-> UniProt:Q13901 (IntAct) [UndirectedInteraction:11155797] UniProt:Q5VWK5 <-> UniProt:Q9NPF7 (IntAct) [UndirectedInteraction:11155799] UniProt:Q5VWK5 <-> UniProt:Q62120 (IntAct)

UniProt:Q5VWK5 IL23R Show undefined attributes

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