UniProt:Q5SGD2 PPM1L

chain
  • chain:1-360
checksum 08212E7BA32AFE2B
comment
  • FUNCTION Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.CATALYTIC ACTIVITY O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphateCATALYTIC ACTIVITY O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphateCOFACTOR Binds 2 magnesium or manganese ions per subunit.SUBUNIT Interacts with MAP3K7/TAK1 (By similarity). Interacts with MAP3K5.SUBCELLULAR LOCATION Ubiquitous. Highly expressed in heart, placenta, lung, liver, kidney and pancreas.SIMILARITY Belongs to the PP2C family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 243665
description
  • recommendedName: Protein phosphatase 1L ecNumber: 3.1.3.16 alternativeName: Protein phosphatase 1-like alternativeName: Protein phosphatase 2C isoform epsilon shortName: PP2C-epsilon
displayName UniProt:Q5SGD2 PPM1L
geneName
  • PPM1L
  • PP2CE
identifier Q5SGD2
isSequenceChanged false
keyword
  • Alternative splicing
  • Hydrolase
  • Magnesium
  • Manganese
  • Membrane
  • Metal-binding
  • Protein phosphatase
  • Proteomics identification
  • Reference proteome
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • PPM1L
otherIdentifier
  • 11738104_a_at
  • 11756821_a_at
  • 151742
  • 16947613
  • 228108_PM_at
  • 228108_at
  • 228457_PM_at
  • 228457_at
  • 229506_PM_at
  • 229506_at
  • 236339_PM_at
  • 236339_at
  • 239488_PM_at
  • 239488_at
  • 2650392
  • 2650394
  • 2650395
  • 2650396
  • 2650397
  • 2650413
  • 2650418
  • 2650419
  • 2650428
  • 2650432
  • 2650433
  • 2650456
  • 2650463
  • 2650465
  • 2650466
  • 2650467
  • 2650468
  • 2650473
  • 2650474
  • 2650476
  • 2650478
  • 2650480
  • 2650481
  • 2650482
  • 2650483
  • 2650485
  • 2650487
  • 2650489
  • 2650490
  • 2650492
  • 53258_at
  • 57656_at
  • 59136_at
  • 59452_at
  • 71667_at
  • 8083749
  • A_23_P147563
  • A_32_P429876
  • GE52965
  • GE85873
  • GO:0000165
  • GO:0003824
  • GO:0004721
  • GO:0004722
  • GO:0005789
  • GO:0006470
  • GO:0006629
  • GO:0007165
  • GO:0007178
  • GO:0016020
  • GO:0016787
  • GO:0030148
  • GO:0043169
  • GO:0046872
  • GO:0070062
  • GO:0140096
  • HMNXSV003047870
  • Hs.12731.0.A1_3p_at
  • Hs.19339.0.A1_3p_at
  • Hs.221001.0.A1_3p_at
  • Hs.28068.0.A1_3p_at
  • Hs.285293.0.A1_3p_at
  • ILMN_1763793
  • PH_hs_0001702
  • PH_hs_0023783
  • TC03002632.hg
  • p26241
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • PPM1L_HUMAN
  • Q2M3J2
  • Q96NM7
sequenceLength 360
species [Species:48887] Homo sapiens
stId uniprot:Q5SGD2
url http://purl.uniprot.org/uniprot/Q5SGD2
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