UniProt:Q5JSL3 DOCK11

chain
  • chain:1-2073
checksum 558FC01EE5D23B6E
comment
  • FUNCTION Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (PubMed:37342957). Required for marginal zone (MZ) B-cell development, is associated with early bone marrow B-cell development, MZ B-cell formation, MZ B-cell number and marginal metallophilic macrophages morphology (By similarity). Facilitates filopodia formation through the activation of CDC42 (PubMed:37342957).SUBUNIT Interacts with CDC42.DOMAIN The DOCKER domain is necessary for the GEF activity. The DOCKER domain mediates interaction with activated CDC42 in conjunction with residues 66-126.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS 'Zizim' means 'spike' in Hebrew.SIMILARITY Belongs to the DOCK family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 227361
description
  • recommendedName: fullName evidence="8"Dedicator of cytokinesis protein 11 alternativeName: Activated Cdc42-associated guanine nucleotide exchange factor shortName: ACG alternativeName: fullName evidence="8"Zizimin-2
displayName UniProt:Q5JSL3 DOCK11
geneName
  • DOCK11
  • ZIZ2
identifier Q5JSL3
isSequenceChanged false
keyword
  • Disease variant
  • Guanine-nucleotide releasing factor
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • DOCK11
otherIdentifier
  • 11723372_a_at
  • 139818
  • 17106438
  • 226875_PM_at
  • 226875_at
  • 238356_PM_at
  • 238356_at
  • 3562607
  • 3562611
  • 3562614
  • 3562615
  • 3562616
  • 3562620
  • 3562625
  • 3562626
  • 3988434
  • 3988436
  • 3988437
  • 3988438
  • 3988451
  • 3988452
  • 3988453
  • 3988454
  • 3988455
  • 3988460
  • 3988461
  • 3988462
  • 3988463
  • 3988464
  • 3988466
  • 3988469
  • 3988470
  • 3988472
  • 3988473
  • 3988474
  • 3988475
  • 3988476
  • 3988477
  • 3988479
  • 3988480
  • 3988481
  • 3988483
  • 3988484
  • 3988485
  • 3988486
  • 3988487
  • 3988489
  • 3988490
  • 3988492
  • 3988493
  • 3988494
  • 3988497
  • 3988498
  • 3988499
  • 3988501
  • 3988502
  • 3988503
  • 3988504
  • 3988506
  • 3988507
  • 3988508
  • 3988509
  • 3988510
  • 3988511
  • 3988513
  • 3988515
  • 3988517
  • 3988518
  • 3988519
  • 3988520
  • 3988521
  • 3988522
  • 3988523
  • 3988526
  • 3988527
  • 3988528
  • 3988529
  • 56864_at
  • 8169541
  • A_24_P76158
  • GE856004
  • GE87380
  • GO:0001782
  • GO:0002315
  • GO:0002376
  • GO:0005085
  • GO:0005515
  • GO:0005829
  • GO:0007264
  • GO:0031267
  • GO:0035023
  • GO:0043547
  • GO:0051491
  • HMNXSV003001653
  • Hs.104157.0.S1_3p_at
  • Hs.107513.0.A1_3p_at
  • ILMN_1765860
  • PH_hs_0005971
  • TC0X000574.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DOC11_HUMAN
  • A6NMF0
  • Q66M66
  • Q6ZUJ5
  • Q86VU8
  • Q96MN3
sequenceLength 2073
species [Species:48887] Homo sapiens
stId uniprot:Q5JSL3
url http://purl.uniprot.org/uniprot/Q5JSL3
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