Reactome | UniProt:Q4KMQ2 ANO6

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UniProt:Q4KMQ2 ANO6 Show undefined attributes

chain	chain:1-910
checksum	8F7F1CB78FAAEB78
comment	FUNCTION Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts (PubMed:20056604, PubMed:21107324, PubMed:21908539, PubMed:22006324, PubMed:22946059). Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes (By similarity).FUNCTION (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, is activated by spike protein which increases the amplitude of spontaneous Ca(2+) signals and is required for spike-mediated syncytia.CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)CATALYTIC ACTIVITY a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in)CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)ACTIVITY REGULATION Exhibits synergistic gating by Ca(2+) and voltage (By similarity). Inhibited by some non-specific cation channel blockers such as: ruthenium red, 2-aminoethyl diphenylborinate (2APB), gadolinium and cadmium ions (By similarity).ACTIVITY REGULATION (Microbial infection) Activated by SARS coronavirus-2/SARS-CoV-2 spike protein.SUBUNIT Homodimer.SUBCELLULAR LOCATION Shows an intracellular localization according to PubMed:22075693.ALTERNATIVE PRODUCTS Expressed in embryonic stem cell, fetal liver, retina, chronic myologenous leukemia and intestinal cancer.INDUCTION (Microbial infection) Expression is induced by SARS coronavirus-2/SARS-CoV-2 spike protein.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS The term 'anoctamin' was coined because these channels are anion selective and are predicted to have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology.SIMILARITY Belongs to the anoctamin family.CAUTION Contains ten transmembrane regions, not eight as predicted.
created	[InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference	[DatabaseIdentifier:11448079] ENSEMBL:ENSG00000177119 [DatabaseIdentifier:11536321] ENSEMBL:ENSP00000409126 [DatabaseIdentifier:11536318] ENSEMBL:ENSP00000506222 [DatabaseIdentifier:11536320] ENSEMBL:ENSP00000320087 [DatabaseIdentifier:11536319] ENSEMBL:ENSP00000413137 [DatabaseIdentifier:11536322] ENSEMBL:ENSP00000391417 [DatabaseIdentifier:11659018] ENSEMBL:ENST00000680201 [DatabaseIdentifier:11659021] ENSEMBL:ENST00000320560 [DatabaseIdentifier:11659019] ENSEMBL:ENST00000441606 [DatabaseIdentifier:11659020] ENSEMBL:ENST00000423947 [DatabaseIdentifier:11659017] ENSEMBL:ENST00000425752 [DatabaseIdentifier:11785778] GeneCards:ANO6 [DatabaseIdentifier:11834175] HMDB Protein:HMDBP07444 [DatabaseIdentifier:11838862] HPA:ENSG00000177119-ANO6 [DatabaseIdentifier:12123376] OpenTargets:ENSG00000177119 [DatabaseIdentifier:12137941] Orphanet:ANO6 [DatabaseIdentifier:12242511] PRO:Q4KMQ2 [DatabaseIdentifier:12283695] Pharos - Targets:Q4KMQ2 [DatabaseIdentifier:12316613] RefSeq:NP_001020527.2 [DatabaseIdentifier:12316612] RefSeq:NP_001136150.1 [DatabaseIdentifier:12316615] RefSeq:NP_001191732.1 [DatabaseIdentifier:12316614] RefSeq:NP_001136151.1
databaseName	UniProt
dbId	251596
description	recommendedName: fullName evidence="14"Anoctamin-6 alternativeName: Small-conductance calcium-activated nonselective cation channel shortName: SCAN channel alternativeName: Transmembrane protein 16F
displayName	UniProt:Q4KMQ2 ANO6
geneName	ANO6 TMEM16F
identifier	Q4KMQ2
isSequenceChanged	false
keyword	Alternative splicing Calcium Cell membrane Chloride Chloride channel Disulfide bond Glycoprotein Host-virus interaction Ion channel Ion transport Lipid transport Membrane Metal-binding Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport Voltage-gated channel
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	ANO6
otherIdentifier	11717410_a_at 11717411_s_at 11717412_x_at 11741730_x_at 11742054_a_at 11745667_a_at 16750325 196527 224906_PM_at 224906_at 240947_PM_at 240947_at 3412572 3412573 3412574 3412576 3412584 3412587 3412590 3412596 3412597 3412602 3412603 3412609 3412610 3412611 3412612 3412614 3412618 3412619 3412621 3412623 3412626 3412628 3412631 3412632 3412633 3412635 3412642 3412643 3412644 3412645 3412646 3412651 3412652 3412653 3412654 3412655 43308_at 45340_at 7954997 A_23_P389118 A_23_P53641 A_33_P3286804 GE86288 GO:0002543 GO:0005227 GO:0005229 GO:0005244 GO:0005247 GO:0005254 GO:0005515 GO:0005829 GO:0005886 GO:0006811 GO:0006821 GO:0006869 GO:0007596 GO:0009986 GO:0016020 GO:0017121 GO:0017128 GO:0030501 GO:0032060 GO:0034220 GO:0034702 GO:0034707 GO:0034767 GO:0035579 GO:0035590 GO:0035725 GO:0043065 GO:0045794 GO:0046872 GO:0046931 GO:0046983 GO:0055085 GO:0060100 GO:0061024 GO:0061589 GO:0061590 GO:0065003 GO:0070062 GO:0070588 GO:0070821 GO:0090026 GO:0097045 GO:1902476 GO:1903766 GO:2000353 HMNXSV003008927 HMNXSV003031175 Hs.269041.0.A1_3p_at Hs.48778.1.S1_3p_at ILMN_1674941 PH_hs_0024852 TC12000329.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6799509] ANO6 [specific granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2684941] ANO6 [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-6800903] ANO6 [tertiary granule membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9853840] ANO6 R419* [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-9853838] ANO6 W407Lfs*5 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000177119] ENSEMBL:ENSG00000177119 ANO6 [ReferenceDNASequence:12671850] UCSC:Q4KMQ2 ANO6 [ReferenceDNASequence:11313650] BioGPS Gene:196527 ANO6 [ReferenceDNASequence:11391375] COSMIC - genes:ANO6 ANO6 [ReferenceDNASequence:11410413] CTD Gene:196527 ANO6 [ReferenceDNASequence:11426992] dbSNP Gene:196527 ANO6 [ReferenceDNASequence:11817409] HGNC:25240 ANO6 [ReferenceDNASequence:11857164] KEGG:hsa:196527 ANO6 [ReferenceDNASequence:11943439] Monarch:196527 ANO6 [ReferenceDNASequence:12027532] NCBI Gene:196527 ANO6 [ReferenceDNASequence:12108901] OMIM:608663 ANO6
referenceTranscript	[ReferenceRNASequence:12498673] RefSeq:NM_001142678.2 ANO6 [ReferenceRNASequence:12498672] RefSeq:NM_001025356.3 ANO6 [ReferenceRNASequence:12498671] RefSeq:NM_001142679.2 ANO6 [ReferenceRNASequence:12498674] RefSeq:NM_001204803.2 ANO6
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ANO6_HUMAN A6NNM6 B9EGG0 E7ENK4 E9PB30 E9PCT2 Q8N3Q2
sequenceLength	910
species	[Species:48887] Homo sapiens
stId	uniprot:Q4KMQ2
url	http://purl.uniprot.org/uniprot/Q4KMQ2

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-6799509] ANO6 [specific granule membrane] [EntityWithAccessionedSequence:R-HSA-2684941] ANO6 [plasma membrane] [EntityWithAccessionedSequence:R-HSA-6800903] ANO6 [tertiary granule membrane] [EntityWithAccessionedSequence:R-HSA-9853840] ANO6 R419* [plasma membrane] [EntityWithAccessionedSequence:R-HSA-9853838] ANO6 W407Lfs*5 [plasma membrane]
(referenceSequence)	[NonsenseMutation:9853852] Nonsense mutation at L-arginine 419 [FragmentReplacedModification:9853839] Replacement of residues 407 to 411 by LGYC
(interactor)	[UndirectedInteraction:11189065] UniProt:O00182 <-> UniProt:Q4KMQ2 (IntAct) [UndirectedInteraction:11202121] UniProt:Q96PC5 <-> UniProt:Q4KMQ2 (IntAct) [UndirectedInteraction:11223009] UniProt:P0DTC5 <-> UniProt:Q4KMQ2 (IntAct) [UndirectedInteraction:11264471] UniProt:P80370 <-> UniProt:Q4KMQ2 (IntAct) [UndirectedInteraction:11299475] UniProt:P27824 <-> UniProt:Q4KMQ2 (IntAct) [UndirectedInteraction:11301615] UniProt:Q8NC56 <-> UniProt:Q4KMQ2 (IntAct)