UniProt:Q49B96 COX19

chain
  • initiator methionine:1
  • chain:2-90
checksum 238A37E8A70EFA09
comment
  • FUNCTION Assembly factor for cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:35750769). Acts as a COX11 chaperone that supports COX11 copper coordination (PubMed:35750769). Also stimulates SCO2-mediated metalation of COX2 (PubMed:35750769). Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis (PubMed:23345593). In the absence of COX11, capable of stimulating copper delivery to the copper B site of COX1 (PubMed:35750769).SUBUNIT Interacts with CHCHD4/MIA40 forming transient intermolecular disulfide bridges (PubMed:23676665). Interacts with COX11; to support COX11 dimerization and copper coordination (PubMed:35750769).SUBCELLULAR LOCATION Partitions between mitochondria and the cytosol in a copper-dependent manner. Enriched in the cytosol when intracellular copper concentrations are elevated.TISSUE SPECIFICITY Ubiquitously expressed. Highly expressed in skeletal muscle.SIMILARITY Belongs to the COX19 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 225020
description
  • recommendedName: Cytochrome c oxidase assembly protein COX19 shortName: hCOX19
displayName UniProt:Q49B96 COX19
geneName
  • COX19
identifier Q49B96
isSequenceChanged false
keyword
  • Acetylation
  • Chaperone
  • Cytoplasm
  • Disulfide bond
  • Mitochondrion
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType Protein
name
  • COX19
otherIdentifier
  • 11727926_a_at
  • 11730822_at
  • 11730823_at
  • 11730824_at
  • 11730825_at
  • 11746479_a_at
  • 11746480_x_at
  • 11751432_a_at
  • 11751433_x_at
  • 17054276
  • 17054302
  • 219150_PM_s_at
  • 219150_s_at
  • 231831_PM_at
  • 231831_at
  • 235533_PM_at
  • 235533_at
  • 3034989
  • 3034990
  • 3034991
  • 3034992
  • 3034993
  • 3034994
  • 3034995
  • 3034997
  • 3034998
  • 3035002
  • 3035003
  • 3035013
  • 3035015
  • 3035020
  • 3035028
  • 3035037
  • 3035038
  • 3035039
  • 3035040
  • 3035041
  • 3035042
  • 3035043
  • 3035044
  • 3035045
  • 3035046
  • 47445_at
  • 47808_at
  • 81174_at
  • 8137680
  • 8137693
  • 84699_at
  • 90265_PM_at
  • 90265_at
  • 90639
  • A_23_P145865
  • A_24_P41391
  • A_32_P9468
  • A_33_P3422133
  • GE54726
  • GE61917
  • GO:0005515
  • GO:0005737
  • GO:0005739
  • GO:0005758
  • GO:0005829
  • GO:0006878
  • GO:0007005
  • GO:0033617
  • GO:0065003
  • HMNXSV003055202
  • Hs.121593.0.S1_3p_at
  • Hs.66104.0.A1_3p_at
  • ILMN_1656656
  • ILMN_2047511
  • PH_hs_0006779
  • PH_hs_0008158
  • TC07003347.hg
  • g6806912_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • COX19_HUMAN
  • A4FTX0
sequenceLength 90
species [Species:48887] Homo sapiens
stId uniprot:Q49B96
url http://purl.uniprot.org/uniprot/Q49B96
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