Reactome | UniProt:Q3T035 ARPC3

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UniProt:Q3T035 ARPC3 Show undefined attributes

chain	chain:1-178
checksum	7149F598B48F0EAC
comment	FUNCTION Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).SUBUNIT Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.SUBCELLULAR LOCATION Belongs to the ARPC3 family.
created	[InstanceEdit:217380] Matthews, L, 2008-03-26 22:25:29
crossReference	[DatabaseIdentifier:12776168] VGNC:53890 [DatabaseIdentifier:12367637] RefSeq:NP_001029443.1 [DatabaseIdentifier:12145716] PDB:1K8K [DatabaseIdentifier:12145706] PDB:2P9L [DatabaseIdentifier:12145726] PDB:3UKU [DatabaseIdentifier:12145717] PDB:7TPT [DatabaseIdentifier:12145710] PDB:1TYQ [DatabaseIdentifier:12145723] PDB:7JPN [DatabaseIdentifier:12145722] PDB:9M64 [DatabaseIdentifier:12145724] PDB:9DLX [DatabaseIdentifier:12145731] PDB:9M5E [DatabaseIdentifier:12145730] PDB:1U2V [DatabaseIdentifier:12145720] PDB:7T5Q [DatabaseIdentifier:12145725] PDB:3UKR [DatabaseIdentifier:12145714] PDB:2P9I [DatabaseIdentifier:12145721] PDB:9DLZ [DatabaseIdentifier:12145729] PDB:3DXM [DatabaseIdentifier:12145728] PDB:3DXK [DatabaseIdentifier:12145711] PDB:2P9U [DatabaseIdentifier:12145705] PDB:2P9N [DatabaseIdentifier:12145708] PDB:4XF2 [DatabaseIdentifier:12145712] PDB:2P9S [DatabaseIdentifier:12145713] PDB:4XEI [DatabaseIdentifier:12145709] PDB:3RSE [DatabaseIdentifier:12145715] PDB:8TAH [DatabaseIdentifier:12145727] PDB:6DEC [DatabaseIdentifier:12145718] PDB:4JD2 [DatabaseIdentifier:12145704] PDB:2P9P [DatabaseIdentifier:12145707] PDB:2P9K [DatabaseIdentifier:12145719] PDB:3ULE [DatabaseIdentifier:11692217] ENSEMBL:ENSBTAT00000007028 [DatabaseIdentifier:11569518] ENSEMBL:ENSBTAP00000007028 [DatabaseIdentifier:11472071] ENSEMBL:ENSBTAG00000005345
databaseName	UniProt
dbId	217381
description	recommendedName: Actin-related protein 2/3 complex subunit 3 alternativeName: Arp2/3 complex 21 kDa subunit shortName: p21-ARC
displayName	UniProt:Q3T035 ARPC3
geneName	ARPC3
identifier	Q3T035
isSequenceChanged	false
keyword	3D-structure Acetylation Actin-binding Cell projection Cytoplasm Cytoskeleton Isopeptide bond Nucleus Phosphoprotein Reference proteome Ubl conjugation
modified	[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType	Protein
name	ARPC3
otherIdentifier	506596 Bt.6795.1.S1_at GO:0003779 GO:0005198 GO:0005200 GO:0005634 GO:0005737 GO:0005856 GO:0005885 GO:0008092 GO:0030027 GO:0030833 GO:0034314 GO:0042995 GO:0051015 GO:1900242
physicalEntity	[EntityWithAccessionedSequence:R-BTA-419944] ARPC3 [cytosol] - Bos taurus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12738150] UCSC:Q3T035 ARPC3 [ReferenceDNASequence:12051035] NCBI Gene:506596 ARPC3 [ReferenceDNASequence:11966942] Monarch:506596 ARPC3 [ReferenceDNASequence:11878188] KEGG:bta:506596 ARPC3 [ReferenceDNASequence:11337153] BioGPS Gene:506596 ARPC3
referenceTranscript	[ReferenceRNASequence:12549465] RefSeq:NM_001034271.2 ARPC3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ARPC3_BOVIN
sequenceLength	178
species	[Species:48898] Bos taurus
stId	uniprot:Q3T035
url	http://purl.uniprot.org/uniprot/Q3T035

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-BTA-419944] ARPC3 [cytosol]