Reactome | UniProt:Q3SYX9 ARPC5

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UniProt:Q3SYX9 ARPC5 Show undefined attributes

chain	initiator methionine:1 chain:2-151
checksum	F39FB10DC68E6F79
comment	FUNCTION Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).SUBUNIT Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.SUBCELLULAR LOCATION Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation.SIMILARITY Belongs to the ARPC5 family.
created	[InstanceEdit:217379] Matthews, L, 2008-03-26 22:25:16
crossReference	[DatabaseIdentifier:12374508] RefSeq:NP_001030524.1 [DatabaseIdentifier:12145719] PDB:3ULE [DatabaseIdentifier:12145704] PDB:2P9P [DatabaseIdentifier:12145708] PDB:4XF2 [DatabaseIdentifier:12145729] PDB:3DXM [DatabaseIdentifier:12145725] PDB:3UKR [DatabaseIdentifier:12145726] PDB:3UKU [DatabaseIdentifier:12145717] PDB:7TPT [DatabaseIdentifier:12145718] PDB:4JD2 [DatabaseIdentifier:12145724] PDB:9DLX [DatabaseIdentifier:12145731] PDB:9M5E [DatabaseIdentifier:12145712] PDB:2P9S [DatabaseIdentifier:12145713] PDB:4XEI [DatabaseIdentifier:12145728] PDB:3DXK [DatabaseIdentifier:12145727] PDB:6DEC [DatabaseIdentifier:12145730] PDB:1U2V [DatabaseIdentifier:12145705] PDB:2P9N [DatabaseIdentifier:12145707] PDB:2P9K [DatabaseIdentifier:12145706] PDB:2P9L [DatabaseIdentifier:12145720] PDB:7T5Q [DatabaseIdentifier:12145716] PDB:1K8K [DatabaseIdentifier:12145711] PDB:2P9U [DatabaseIdentifier:12145709] PDB:3RSE [DatabaseIdentifier:12145710] PDB:1TYQ [DatabaseIdentifier:12145721] PDB:9DLZ [DatabaseIdentifier:12145722] PDB:9M64 [DatabaseIdentifier:12145714] PDB:2P9I
databaseName	UniProt
dbId	217378
description	recommendedName: Actin-related protein 2/3 complex subunit 5 alternativeName: Arp2/3 complex 16 kDa subunit shortName: p16-ARC
displayName	UniProt:Q3SYX9 ARPC5
geneName	ARPC5
identifier	Q3SYX9
isSequenceChanged	false
keyword	3D-structure Acetylation Actin-binding Cell projection Cytoplasm Cytoskeleton Nucleus Reference proteome Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	ARPC5
physicalEntity	[EntityWithAccessionedSequence:R-BTA-419930] ARPC5 [cytosol] - Bos taurus
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12739672] UCSC:Q3SYX9 ARPC5 [ReferenceDNASequence:12054221] NCBI Gene:614345 ARPC5 [ReferenceDNASequence:11970128] Monarch:614345 ARPC5 [ReferenceDNASequence:11881131] KEGG:bta:614345 ARPC5 [ReferenceDNASequence:11340339] BioGPS Gene:614345 ARPC5
referenceTranscript	[ReferenceRNASequence:12556296] RefSeq:NM_001035447.2 ARPC5
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ARPC5_BOVIN
sequenceLength	151
species	[Species:48898] Bos taurus
stId	uniprot:Q3SYX9
url	http://purl.uniprot.org/uniprot/Q3SYX9

Referrals

(referenceEntity)

[EntityWithAccessionedSequence:R-BTA-419930] ARPC5 [cytosol]