UniProt:Q3MII6 TBC1D25

chain
  • chain:1-688
checksum 5B070FE11D78D0A4
comment
  • FUNCTION Acts as a GTPase-activating protein specific for RAB33B. Involved in the regulation of autophagosome maturation, the process in which autophagosomes fuse with endosomes and lysosomes.SUBUNIT Interacts (via N-terminus) with MAP1LC3B, GABARAP and GABARAPL2.INTERACTION It is dispersed in the cytoplasm under nutrient-rich conditions. Localizes at autophagosomes under cell starving conditions.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 250648
description
  • recommendedName: TBC1 domain family member 25
displayName UniProt:Q3MII6 TBC1D25
geneName
  • TBC1D25
  • OATL1
identifier Q3MII6
isSequenceChanged false
keyword
  • Alternative splicing
  • Autophagy
  • Cytoplasm
  • Cytoplasmic vesicle
  • GTPase activation
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • TBC1D25
otherIdentifier
  • 11722611_at
  • 11748734_s_at
  • 11748753_a_at
  • 17103340
  • 226173_PM_at
  • 226173_at
  • 227820_PM_at
  • 227820_at
  • 3976690
  • 3976691
  • 3976692
  • 3976693
  • 3976694
  • 3976696
  • 3976697
  • 3976698
  • 3976699
  • 3976700
  • 3976701
  • 3976702
  • 4943
  • 54513_at
  • 64213_at
  • 8167314
  • A_23_P159693
  • GE88075
  • GO:0005096
  • GO:0005515
  • GO:0005737
  • GO:0005773
  • GO:0005776
  • GO:0006914
  • GO:0008483
  • GO:0016740
  • GO:0031410
  • GO:0098772
  • GO:1901096
  • HMNXSV003034224
  • Hs.30619.0.S1_3p_at
  • Hs.6570.0.A1_3p_at
  • ILMN_1681855
  • ILMN_1768491
  • PH_hs_0031128
  • TC0X000254.hg
  • TC0X001697.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • TBC25_HUMAN
  • Q08AN9
  • Q3MII4
  • Q8TAR9
sequenceLength 688
species [Species:48887] Homo sapiens
stId uniprot:Q3MII6
url http://purl.uniprot.org/uniprot/Q3MII6
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