UniProt:Q3MHR7 ARPC2

chain
  • chain:1-300
checksum 60801D999BFBF947
comment
  • FUNCTION Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the mother actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).SUBUNIT Component of the Arp2/3 complex composed of ACTR2/ARP2, ACTR3/ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC (PubMed:11721045, PubMed:15505213). Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex (By similarity). Interacts with DNAI3; this interaction reduces binding of the Arp2/3 complex to the VCA domain of nucleation promoting factors (By similarity).SUBCELLULAR LOCATION Belongs to the ARPC2 family.
created [InstanceEdit:217377] Matthews, L, 2008-03-26 22:25:05
crossReference
databaseName UniProt
dbId 217376
description
  • recommendedName: Actin-related protein 2/3 complex subunit 2 alternativeName: Arp2/3 complex 34 kDa subunit shortName: p34-ARC
displayName UniProt:Q3MHR7 ARPC2
geneName
  • ARPC2
identifier Q3MHR7
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Actin-binding
  • Cell projection
  • Cytoplasm
  • Cytoskeleton
  • Nucleus
  • Reference proteome
  • Synapse
  • Synaptosome
modified [InstanceEdit:9852000] Weiser, Joel, 2023-11-03
moleculeType Protein
name
  • ARPC2
otherIdentifier
  • 540838
  • Bt.6846.1.S1_at
  • GO:0005198
  • GO:0005200
  • GO:0005654
  • GO:0005768
  • GO:0005856
  • GO:0005885
  • GO:0005886
  • GO:0005925
  • GO:0008092
  • GO:0010592
  • GO:0015629
  • GO:0030027
  • GO:0030041
  • GO:0030672
  • GO:0030838
  • GO:0031252
  • GO:0034314
  • GO:0036195
  • GO:0045202
  • GO:0051015
  • GO:0098793
  • GO:0098794
  • GO:0098978
  • GO:1900026
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • ARPC2_BOVIN
sequenceLength 300
species [Species:48898] Bos taurus
stId uniprot:Q3MHR7
url http://purl.uniprot.org/uniprot/Q3MHR7
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