UniProt:Q24592 hop

chain
  • chain:1-1177
checksum BF8587C420BF3A8F
comment
  • FUNCTION Tyrosine kinase of the non-receptor type, phosphorylates the marelle protein. Required maternally for the establishment of the normal array of embryonic segments: involved in the control of pair-rule gene transcription in a stripe-specific manner. Together with Hsp83 and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)SUBUNIT Forms a complex with Hsp83 and piwi; probably Hop mediates the interaction between piwi and Hsp83.SUBCELLULAR LOCATION Wholly intracellular, possibly membrane associated.DEVELOPMENTAL STAGE Expressed both maternally and zygotically throughout development.DOMAIN Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1 (By similarity).SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.
crossReference
databaseName UniProt
dbId 93495
description
  • recommendedName: Tyrosine-protein kinase hopscotch ecNumber: 2.7.10.2
displayName UniProt:Q24592 hop
geneName
  • hop
  • HD-160
  • CG1594
identifier Q24592
isSequenceChanged false
keyword
  • ATP-binding
  • Developmental protein
  • Kinase
  • Membrane
  • Nucleotide-binding
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • SH2 domain
  • Transcription
  • Transcription regulation
  • Transferase
  • Tyrosine-protein kinase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • hop
otherIdentifier
  • 153404_at
  • 1639072_at
  • 32080
  • GO:0000166
  • GO:0001745
  • GO:0001751
  • GO:0002009
  • GO:0002376
  • GO:0003824
  • GO:0004672
  • GO:0004713
  • GO:0004715
  • GO:0005126
  • GO:0005524
  • GO:0005829
  • GO:0005856
  • GO:0006468
  • GO:0007259
  • GO:0007298
  • GO:0007350
  • GO:0007365
  • GO:0007399
  • GO:0007424
  • GO:0007442
  • GO:0007455
  • GO:0007472
  • GO:0007478
  • GO:0007481
  • GO:0007538
  • GO:0007616
  • GO:0009887
  • GO:0009898
  • GO:0012505
  • GO:0016020
  • GO:0016301
  • GO:0016318
  • GO:0016476
  • GO:0016740
  • GO:0019100
  • GO:0019221
  • GO:0019827
  • GO:0030154
  • GO:0030182
  • GO:0030707
  • GO:0030713
  • GO:0031453
  • GO:0035167
  • GO:0035206
  • GO:0035556
  • GO:0038127
  • GO:0042067
  • GO:0042386
  • GO:0045317
  • GO:0045475
  • GO:0048468
  • GO:0048749
  • GO:0048856
  • GO:0048870
  • GO:0050793
  • GO:0050877
  • GO:0051130
  • GO:0051607
  • GO:0060031
  • GO:0065008
  • GO:0071907
  • GO:0071944
  • GO:0098542
  • GO:0140096
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • JAK_DROME
  • Q712V3
  • Q8SZI9
  • Q9VYZ7
sequenceLength 1177
species [Species:56210] Drosophila melanogaster
stId uniprot:Q24592
url http://purl.uniprot.org/uniprot/Q24592

Referrals

(referenceEntity)
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