UniProt:Q1RMZ1 SAMTOR

chain
  • chain:1-405
checksum 5C19614953ABD670
comment
  • FUNCTION S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071, PubMed:35776786). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071, PubMed:35776786). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071, PubMed:35776786). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential).SUBUNIT Interacts with the DEPDC5 subunit of the GATOR1 complex; interaction is disrupted when SAMTOR binds S-adenosyl-L-methionine (PubMed:29123071, PubMed:29590090, PubMed:35776786). Interacts with the KICSTOR complex; interaction is disrupted when SAMTOR binds S-adenosyl-L-methionine (PubMed:29123071, PubMed:35776786).SIMILARITY Belongs to the BMT2/SAMTOR family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 253391
description
  • recommendedName: fullName evidence="1 6"S-adenosylmethionine sensor upstream of mTORC1 alternativeName: fullName evidence="1"Probable methyltransferase BMT2 homolog ecNumber evidence="1"2.1.1.-
displayName UniProt:Q1RMZ1 SAMTOR
geneName
  • SAMTOR
  • BMT2
  • C7orf60
identifier Q1RMZ1
isSequenceChanged false
keyword
  • Methyltransferase
  • Proteomics identification
  • Reference proteome
  • S-adenosyl-L-methionine
  • Transferase
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • SAMTOR
otherIdentifier
  • 11723621_at
  • 11751431_a_at
  • 154743
  • 17061972
  • 228149_PM_at
  • 228149_at
  • 3068523
  • 3068524
  • 3068525
  • 3068526
  • 3068527
  • 3068528
  • 3068533
  • 3068540
  • 3068541
  • 3068545
  • 3068550
  • 3068554
  • 3068555
  • 3068556
  • 3068557
  • 3068558
  • 47554_at
  • 8142415
  • 85384_at
  • A_24_P163590
  • A_24_P303647
  • A_33_P3413855
  • GE79228
  • GO:0002181
  • GO:0005829
  • GO:0008168
  • GO:0016740
  • GO:0031503
  • GO:0031669
  • GO:0032259
  • GO:0034198
  • GO:0038202
  • GO:0044877
  • GO:0045947
  • GO:0045948
  • GO:0061431
  • GO:0061462
  • GO:1903432
  • GO:1904047
  • GO:1904262
  • GO:1904263
  • HMNXSV003032093
  • Hs.292478.0.A1_3p_at
  • ILMN_1658210
  • PH_hs_0015176
  • TC07001765.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SAMTR_HUMAN
  • Q8N3D0
  • Q96MV7
sequenceLength 405
species [Species:48887] Homo sapiens
stId uniprot:Q1RMZ1
url http://purl.uniprot.org/uniprot/Q1RMZ1
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