Reactome | UniProt:Q16832 DDR2

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UniProt:Q16832 DDR2 Show undefined attributes

chain	signal peptide:1-21 chain:22-855
checksum	78662021BC53E1A0
comment	FUNCTION Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as a cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)ACTIVITY REGULATION Present in an inactive state in the absence of collagen binding and phosphorylation by SRC. Tyrosine phosphorylation enhances the affinity for ATP and the catalytic activity.SUBUNIT Binds hydroxyproline-rich sequence motifs in fibrillar, glycosylated collagen, such as the GQOGVMGFO motif, where O stands for hydroxyproline. Interacts with SRC. Interacts (tyrosine phosphorylated) with SHC1.INTERACTION Detected in osteocytes, osteoblastic cells in subchondral bone, bone lining cells, tibia and cartilage (at protein level). Detected at high levels in heart and lung, and at low levels in brain, placenta, liver, skeletal muscle, pancreas, and kidney.INDUCTION Up-regulated during osteoblast differentiation (in vitro). Up-regulated in cartilage from osteoarthritis patients.PTM N-glycosylated.PTM Tyrosine phosphorylated in response to collagen binding. Phosphorylated by SRC; this is required for activation and subsequent autophosphorylation on additional tyrosine residues.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.
crossReference	[DatabaseIdentifier:11480179] ENSEMBL:ENSG00000162733 [DatabaseIdentifier:12818142] ZINC - World Drugs:DDR2_HUMAN [DatabaseIdentifier:12814499] ZINC target:Q16832 [DatabaseIdentifier:12811187] ZINC - Substances:DDR2_HUMAN [DatabaseIdentifier:12808599] ZINC - Predictions - Purchasable:DDR2_HUMAN [DatabaseIdentifier:12806646] ZINC - Investigational:DDR2_HUMAN [DatabaseIdentifier:12805577] ZINC - FDA approved:DDR2_HUMAN [DatabaseIdentifier:12804420] ZINC - Biogenic:DDR2_HUMAN [DatabaseIdentifier:11580728] ENSEMBL:ENSP00000400309 [DatabaseIdentifier:11580729] ENSEMBL:ENSP00000356898 [DatabaseIdentifier:11580730] ENSEMBL:ENSP00000356899 [DatabaseIdentifier:11703429] ENSEMBL:ENST00000367921 [DatabaseIdentifier:11703428] ENSEMBL:ENST00000367922 [DatabaseIdentifier:11703427] ENSEMBL:ENST00000446985 [DatabaseIdentifier:11779128] Guide to Pharmacology - Targets:1844 [DatabaseIdentifier:11792735] GeneCards:DDR2 [DatabaseIdentifier:11808830] GlyGen:Q16832 [DatabaseIdentifier:11829451] HMDB Protein:HMDBP01265 [DatabaseIdentifier:11845725] HPA:ENSG00000162733-DDR2 [DatabaseIdentifier:12130374] OpenTargets:ENSG00000162733 [DatabaseIdentifier:12135120] Orphanet:DDR2 [DatabaseIdentifier:12214604] PDB:7AZB [DatabaseIdentifier:12214603] PDB:7AYM [DatabaseIdentifier:12214600] PDB:2WUH [DatabaseIdentifier:12214602] PDB:6FER [DatabaseIdentifier:12214601] PDB:2Z4F [DatabaseIdentifier:12273282] PRO:Q16832 [DatabaseIdentifier:12290578] Pharos - Targets:Q16832 [DatabaseIdentifier:12385155] RefSeq:XP_011507889.1 [DatabaseIdentifier:12385154] RefSeq:NP_001014796.1 [DatabaseIdentifier:12385157] RefSeq:NP_006173.2 [DatabaseIdentifier:12385159] RefSeq:XP_047277510.1 [DatabaseIdentifier:12385158] RefSeq:NP_001341912.1 [DatabaseIdentifier:12385160] RefSeq:NP_001341911.1 [DatabaseIdentifier:12385153] RefSeq:XP_054192777.1 [DatabaseIdentifier:12385156] RefSeq:XP_054192778.1
databaseName	UniProt
dbId	53502
description	recommendedName: Discoidin domain-containing receptor 2 shortName: Discoidin domain receptor 2 ecNumber: 2.7.10.1 alternativeName: CD167 antigen-like family member B alternativeName: Discoidin domain-containing receptor tyrosine kinase 2 alternativeName: Neurotrophic tyrosine kinase, receptor-related 3 alternativeName: Receptor protein-tyrosine kinase TKT alternativeName: Tyrosine-protein kinase TYRO10 cdAntigenNameCD167b/cdAntigenName
displayName	UniProt:Q16832 DDR2
geneName	DDR2 NTRKR3 TKT TYRO10
identifier	Q16832
isSequenceChanged	false
keyword	3D-structure ATP-binding Cell membrane Disease variant Disulfide bond Dwarfism Glycoprotein Kinase Membrane Nucleotide-binding Osteogenesis Phosphoprotein Proteomics identification Receptor Reference proteome Signal Transferase Transmembrane Transmembrane helix Tyrosine-protein kinase
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	DDR2
otherIdentifier	11723859_a_at 11744349_s_at 11757788_s_at 11759442_s_at 11759547_s_at 11760934_x_at 1319_at 16673075 205168_PM_at 205168_at 225442_PM_at 225442_at 227561_PM_at 227561_at 235631_PM_at 235631_at 2364232 2364233 2364234 2364235 2364236 2364243 2364253 2364257 2364258 2364259 2364269 2364270 2364271 2364272 2364273 2364274 2364278 2364279 2364280 2364281 2364282 2364283 2364284 2364285 2364287 2364288 2364291 2364292 2364293 2364294 2364295 2364296 2364297 2364299 2364301 2364302 2364303 2364304 2364305 2364306 244075_PM_at 244075_at 3243265 3243268 3243270 3243271 3243272 3243273 45199_at 48967_at 4921 68597_at 7906878 7906900 82956_at A_14_P114165 A_23_P452 A_32_P88965 A_33_P3276376 GE59995 GE861252 GO:0000166 GO:0001503 GO:0003416 GO:0003824 GO:0004672 GO:0004713 GO:0004714 GO:0005515 GO:0005518 GO:0005524 GO:0005856 GO:0005886 GO:0005925 GO:0006355 GO:0006468 GO:0007155 GO:0007165 GO:0007169 GO:0008284 GO:0010715 GO:0010763 GO:0010976 GO:0015629 GO:0016020 GO:0016301 GO:0016324 GO:0016740 GO:0018108 GO:0030198 GO:0030199 GO:0030500 GO:0031214 GO:0032967 GO:0034103 GO:0035988 GO:0035994 GO:0038062 GO:0038063 GO:0043066 GO:0043235 GO:0045669 GO:0045860 GO:0046777 GO:0048146 GO:0048856 GO:0051091 GO:0051897 GO:0070374 GO:0071456 GO:0071560 GO:0090091 GO:0090303 GO:0140096 GO:1900087 GO:1901299 GO:1904385 GO:1904707 GO:1904754 GO:1904899 GO:2000491 HMNXSV003008235 HMNXSV003047825 Hs.146299.0.A1_3p_at Hs.15248.0.S1_3p_at Hs.192152.0.A1_3p_at Hs.42392.0.A1_3p_at ILMN_1664398 ILMN_1675794 ILMN_2410523 PH_hs_0025814 PH_hs_0041097 TC01001423.hg TC01001425.hg TC01004802.hg X74764_at g5453813_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-211419] DDR2 [plasma membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000162733] ENSEMBL:ENSG00000162733 DDR2 [ReferenceDNASequence:12692517] UCSC:Q16832 DDR2 [ReferenceDNASequence:11345766] BioGPS Gene:4921 DDR2 [ReferenceDNASequence:11393037] COSMIC - genes:DDR2 DDR2 [ReferenceDNASequence:11393038] COSMIC - genes:TKT DDR2 [ReferenceDNASequence:11421000] CTD Gene:4921 DDR2 [ReferenceDNASequence:11428959] dbSNP Gene:4921 DDR2 [ReferenceDNASequence:11824419] HGNC:2731 DDR2 [ReferenceDNASequence:11886001] KEGG:hsa:4921 DDR2 [ReferenceDNASequence:11975555] Monarch:4921 DDR2 [ReferenceDNASequence:12059648] NCBI Gene:4921 DDR2 [ReferenceDNASequence:12114938] OMIM:191311 DDR2
referenceTranscript	[ReferenceRNASequence:12566945] RefSeq:XM_054336802.1 DDR2 [ReferenceRNASequence:12566951] RefSeq:XM_011509587.3 DDR2 [ReferenceRNASequence:12566947] RefSeq:XM_054336803.1 DDR2 [ReferenceRNASequence:12566950] RefSeq:NM_001354983.2 DDR2 [ReferenceRNASequence:12566944] RefSeq:XM_047421554.1 DDR2 [ReferenceRNASequence:12566949] RefSeq:NM_001354982.2 DDR2 [ReferenceRNASequence:12566948] RefSeq:NM_006182.4 DDR2 [ReferenceRNASequence:12566946] RefSeq:NM_001014796.3 DDR2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	DDR2_HUMAN Q7Z730
sequenceLength	855
species	[Species:48887] Homo sapiens
stId	uniprot:Q16832
url	http://purl.uniprot.org/uniprot/Q16832

Referrals

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-211419] DDR2 [plasma membrane]
(interactor)	[UndirectedInteraction:11153407] UniProt:P29353 <-> UniProt:Q16832 (IntAct) [UndirectedInteraction:11267545] UniProt:Q16288 <-> UniProt:Q16832 (IntAct) [UndirectedInteraction:11279307] UniProt:P08238 <-> UniProt:Q16832 (IntAct)