Reactome | UniProt:Q16787 LAMA3

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UniProt:Q16787 LAMA3 Show undefined attributes

chain	signal peptide:1-35 chain:36-3333
checksum	6F99AF4D4B99FCB0
comment	FUNCTION Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.FUNCTION Laminin-5 is thought to be involved in (1) cell adhesion via integrin alpha-3/beta-1 in focal adhesion and integrin alpha-6/beta-4 in hemidesmosomes, (2) signal transduction via tyrosine phosphorylation of pp125-FAK and p80, (3) differentiation of keratinocytes.SUBUNIT Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-3 is a subunit of laminin-5 (laminin-332 or epiligrin/kalinin/nicein), laminin-6 (laminin-311 or K-laminin) and laminin-7 (laminin-321 or KS-laminin).SUBCELLULAR LOCATION Major component.ALTERNATIVE PRODUCTS Skin; respiratory, urinary, and digestive epithelia and in other specialized tissues with prominent secretory or protective functions. Epithelial basement membrane, and epithelial cell tongue that migrates into a wound bed. A differential and focal expression of the subunit alpha-3 is observed in the CNS.INDUCTION Laminin-5 is up-regulated in wound sites of human skin.DOMAIN The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structure.DOMAIN Domain G is globular.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.
crossReference	[DatabaseIdentifier:12386182] RefSeq:NP_000218.3 [DatabaseIdentifier:12386185] RefSeq:NP_001289925.1 [DatabaseIdentifier:12386186] RefSeq:NP_001121190.2 [DatabaseIdentifier:12386184] RefSeq:NP_001121189.2 [DatabaseIdentifier:12386183] RefSeq:NP_937762.2 [DatabaseIdentifier:12291087] Pharos - Targets:Q16787 [DatabaseIdentifier:12273795] PRO:Q16787 [DatabaseIdentifier:12135442] Orphanet:LAMA3 [DatabaseIdentifier:12130891] OpenTargets:ENSG00000053747 [DatabaseIdentifier:11846235] HPA:ENSG00000053747-LAMA3 [DatabaseIdentifier:11809264] GlyGen:Q16787 [DatabaseIdentifier:11793246] GeneCards:LAMA3 [DatabaseIdentifier:11704069] ENSEMBL:ENST00000313654 [DatabaseIdentifier:11704067] ENSEMBL:ENST00000587184 [DatabaseIdentifier:11704068] ENSEMBL:ENST00000269217 [DatabaseIdentifier:11704070] ENSEMBL:ENST00000399516 [DatabaseIdentifier:11581368] ENSEMBL:ENSP00000269217 [DatabaseIdentifier:11581369] ENSEMBL:ENSP00000382432 [DatabaseIdentifier:11581370] ENSEMBL:ENSP00000324532 [DatabaseIdentifier:11581371] ENSEMBL:ENSP00000466557 [DatabaseIdentifier:11480633] ENSEMBL:ENSG00000053747
databaseName	UniProt
dbId	58613
description	recommendedName: Laminin subunit alpha-3 alternativeName: Epiligrin 170 kDa subunit shortName: E170 alternativeName: Epiligrin subunit alpha alternativeName: Kalinin subunit alpha alternativeName: Laminin-5 subunit alpha alternativeName: Laminin-6 subunit alpha alternativeName: Laminin-7 subunit alpha alternativeName: Nicein subunit alpha
displayName	UniProt:Q16787 LAMA3
geneName	LAMA3 LAMNA
identifier	Q16787
isSequenceChanged	false
keyword	Alternative splicing Basement membrane Cell adhesion Coiled coil Disease variant Disulfide bond Epidermolysis bullosa Extracellular matrix Glycoprotein Laminin EGF-like domain Proteomics identification Reference proteome Repeat Secreted Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	LAMA3
otherIdentifier	11742184_a_at 1560078_PM_at 1560078_at 1563772_PM_a_at 1563772_a_at 1568879_PM_a_at 1568879_a_at 16851486 203726_PM_s_at 203726_s_at 3781796 3781797 3781798 3781799 3781800 3781801 3781802 3781808 3781824 3781825 3781826 3781829 3781832 3781833 3781836 3781839 3781840 3781841 3781842 3781846 3781850 3781851 3781855 3781856 3781859 3781861 3781863 3781864 3781865 3781866 3781868 3781869 3781870 3781871 3781873 3781875 3781877 3781878 3781879 3781882 3781883 3781884 3781885 3781886 3781888 3781889 3781890 3781892 3781893 3781896 3781903 3781904 3781906 3781907 3781908 3781909 3781911 3781912 3781913 3781914 3781915 3781916 3781918 3781919 3781920 3781922 3781923 3781924 3781925 3781926 3781927 3781928 3781929 3781930 3781931 3781932 3781933 3781935 3781937 3781939 3781940 3781942 3781943 3781944 3781945 3781946 3781947 3781948 3781949 3781950 3781951 3781952 3781953 3781954 3781955 3781956 3781957 3781962 3781963 3781964 3781965 3781966 3781968 3781969 3781970 3781971 3781972 3781973 3781974 3781975 37909_at 3909 8020551 A_14_P108153 A_23_P89780 A_24_P179569 A_24_P687302 A_33_P3262560 GE60095 GO:0005102 GO:0005198 GO:0005201 GO:0005576 GO:0005604 GO:0005608 GO:0005610 GO:0005783 GO:0005912 GO:0007155 GO:0008544 GO:0009653 GO:0016020 GO:0030056 GO:0030154 GO:0030155 GO:0030312 GO:0030334 GO:0031012 GO:0031581 GO:0034330 GO:0035987 GO:0045995 GO:0048856 GO:0070062 GO:0098609 HMNXSV003018857 HMNXSV003037726 Hs2.151169.1.S1_3p_at Hs2.151169.2.S1_3p_a_at Hs2.151169.2.S1_3p_at Hs2.151169.3.S1_3p_a_at ILMN_1688892 ILMN_1704247 ILMN_2293594 ILMN_2406035 L34155_at PH_hs_0029016 TC18000103.hg g4557710_3p_a_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2533899] LAMA3(36-?) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2533924] LAMA3(?-3333) [extracellular region] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-445991] LAMA3 [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12692824] UCSC:Q16787 LAMA3 [ReferenceDNASequence:12115405] OMIM:600805 LAMA3 [ReferenceDNASequence:12060039] NCBI Gene:3909 LAMA3 [ReferenceDNASequence:11975946] Monarch:3909 LAMA3 [ReferenceDNASequence:11886333] KEGG:hsa:3909 LAMA3 [ReferenceDNASequence:11824936] HGNC:6483 LAMA3 [ReferenceDNASequence:11429027] dbSNP Gene:3909 LAMA3 [ReferenceDNASequence:11421656] CTD Gene:3909 LAMA3 [ReferenceDNASequence:11393099] COSMIC - genes:LAMA3 LAMA3 [ReferenceDNASequence:11346157] BioGPS Gene:3909 LAMA3 [ReferenceDNASequence:ensembl:ENSG00000053747] ENSEMBL:ENSG00000053747 LAMA3
referenceTranscript	[ReferenceRNASequence:12567987] RefSeq:NM_198129.4 LAMA3 [ReferenceRNASequence:12567986] RefSeq:NM_001127718.4 LAMA3 [ReferenceRNASequence:12567985] RefSeq:NM_001127717.4 LAMA3 [ReferenceRNASequence:12567983] RefSeq:NM_000227.4 LAMA3 [ReferenceRNASequence:12567984] RefSeq:NM_001302996.1 LAMA3
schemaClass	ReferenceGeneProduct
secondaryIdentifier	LAMA3_HUMAN B0YJ33 Q13679 Q13680 Q6VU67 Q6VU68 Q6VU69 Q76E14 Q96TG0
sequenceLength	3333
species	[Species:48887] Homo sapiens
stId	uniprot:Q16787
url	http://purl.uniprot.org/uniprot/Q16787

Referrals

(interactor)	[UndirectedInteraction:11276653] UniProt:P59665 <-> UniProt:Q16787 (IntAct) [UndirectedInteraction:11148515] UniProt:P13569 <-> UniProt:Q16787 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2533899] LAMA3(36-?) [extracellular region] [EntityWithAccessionedSequence:R-HSA-2533924] LAMA3(?-3333) [extracellular region] [EntityWithAccessionedSequence:R-HSA-445991] LAMA3 [extracellular region]