Reactome | UniProt:Q16763 UBE2S

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UniProt:Q16763 UBE2S Show undefined attributes

chain	chain:1-222
checksum	2842DC3DCD2AFCB5
comment	FUNCTION Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:19820702, PubMed:19822757, PubMed:22496338, PubMed:27259151). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis (PubMed:19820702, PubMed:19822757, PubMed:27259151, PubMed:27910872). Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874).CATALYTIC ACTIVITY S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.PATHWAY Protein modification; protein ubiquitination.SUBUNIT Component of the APC/C complex, composed of at least 14 distinct subunits that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa. Within this complex, directly interacts with ANAPC2 and ANAPC4 (PubMed:27259151). Interacts with CDC20, FZR1/CDH1 and VHL (PubMed:16819549, PubMed:19822757).INTERACTION Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.SIMILARITY Belongs to the ubiquitin-conjugating enzyme family.
crossReference	[DatabaseIdentifier:12386105] RefSeq:NP_055316.2 [DatabaseIdentifier:12291010] Pharos - Targets:Q16763 [DatabaseIdentifier:12273727] PRO:Q16763 [DatabaseIdentifier:12147544] PDB:5L9T [DatabaseIdentifier:12216486] PDB:6S96 [DatabaseIdentifier:12216485] PDB:7AHF [DatabaseIdentifier:12216489] PDB:6QHK [DatabaseIdentifier:12147543] PDB:8TAU [DatabaseIdentifier:12160030] PDB:5BNB [DatabaseIdentifier:12216488] PDB:6S98 [DatabaseIdentifier:12216490] PDB:6QH3 [DatabaseIdentifier:12216487] PDB:1ZDN [DatabaseIdentifier:12130813] OpenTargets:ENSG00000108106 [DatabaseIdentifier:11850039] IntEnz:2.3.2.23 [DatabaseIdentifier:11846157] HPA:ENSG00000108106-UBE2S [DatabaseIdentifier:11829919] HMDB Protein:HMDBP09277 [DatabaseIdentifier:11793170] GeneCards:UBE2S [DatabaseIdentifier:11704016] ENSEMBL:ENST00000264552 [DatabaseIdentifier:11581317] ENSEMBL:ENSP00000264552 [DatabaseIdentifier:11480593] ENSEMBL:ENSG00000108106
databaseName	UniProt
dbId	66751
description	recommendedName: Ubiquitin-conjugating enzyme E2 S ecNumber evidence="5 6 7 12"2.3.2.23 alternativeName: E2 ubiquitin-conjugating enzyme S alternativeName: E2-EPF alternativeName: Ubiquitin carrier protein S alternativeName: Ubiquitin-conjugating enzyme E2-24 kDa alternativeName: Ubiquitin-conjugating enzyme E2-EPF5 alternativeName: Ubiquitin-protein ligase S
displayName	UniProt:Q16763 UBE2S
geneName	UBE2S E2EPF OK/SW-cl.73
identifier	Q16763
isSequenceChanged	false
keyword	3D-structure Acetylation ATP-binding Cell cycle Cell division Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Transferase Ubl conjugation Ubl conjugation pathway
modified	[InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType	Protein
name	UBE2S
otherIdentifier	11719849_s_at 16875763 202779_PM_s_at 202779_s_at 27338 3713481 3713482 3713483 3713484 3747002 3747003 3747004 3747005 3747006 3871444 3871446 3871447 3871450 3871451 3871452 3871453 3871454 3871455 3871456 40619_at 8012958 8039491 893_at 894_g_at A_32_P184933 GE58141 GO:0000166 GO:0000209 GO:0003824 GO:0004842 GO:0005515 GO:0005524 GO:0005634 GO:0005654 GO:0005680 GO:0005829 GO:0006511 GO:0010458 GO:0010994 GO:0010997 GO:0016567 GO:0016740 GO:0019787 GO:0030163 GO:0031145 GO:0031146 GO:0032446 GO:0035519 GO:0036211 GO:0043161 GO:0044314 GO:0051301 GO:0061631 GO:0070534 GO:0070979 GO:0085020 GO:0140096 GO:1904668 HMNXSV003019095 ILMN_1808591 ILMN_2217289 M91670_at PH_hs_0030491 TC17001166.hg TC19001872.hg g7657045_3p_x_at p8460
physicalEntity	[EntityWithAccessionedSequence:R-HSA-8864164] Ub-C95-UBE2S [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8864181] Ub-C95-UBE2S [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8852051] UBE2S [nucleoplasm] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-947622] UBE2S [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12692787] UCSC:Q16763 UBE2S [ReferenceDNASequence:12115331] OMIM:610309 UBE2S [ReferenceDNASequence:12060002] NCBI Gene:27338 UBE2S [ReferenceDNASequence:11975909] Monarch:27338 UBE2S [ReferenceDNASequence:11886302] KEGG:hsa:27338 UBE2S [ReferenceDNASequence:11824858] HGNC:17895 UBE2S [ReferenceDNASequence:11429012] dbSNP Gene:27338 UBE2S [ReferenceDNASequence:11421566] CTD Gene:27338 UBE2S [ReferenceDNASequence:11393088] COSMIC - genes:UBE2S UBE2S [ReferenceDNASequence:11346120] BioGPS Gene:27338 UBE2S [ReferenceDNASequence:ensembl:ENSG00000108106] ENSEMBL:ENSG00000108106 UBE2S
referenceTranscript	[ReferenceRNASequence:12567906] RefSeq:NM_014501.3 UBE2S
schemaClass	ReferenceGeneProduct
secondaryIdentifier	UBE2S_HUMAN Q9BTC1
sequenceLength	222
species	[Species:48887] Homo sapiens
stId	uniprot:Q16763
url	http://purl.uniprot.org/uniprot/Q16763

Referrals

(interactor)	[UndirectedInteraction:11149245] UniProt:P13569 <-> UniProt:Q16763 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-8864164] Ub-C95-UBE2S [cytosol] [EntityWithAccessionedSequence:R-HSA-8864181] Ub-C95-UBE2S [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-8852051] UBE2S [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-947622] UBE2S [cytosol]
(referenceSequence)	[ModifiedResidue:8864173] S-(glycyl)-L-cysteine (Cys-Gly) at 95