UniProt:Q16696 CYP2A13

chain
  • chain:1-494
checksum A39F18AD71C28821
comment
  • FUNCTION Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity.CATALYTIC ACTIVITY an organic molecule + reduced [NADPH--hemoprotein reductase] + O2 = an alcohol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)COFACTOR Expressed in liver and a number of extrahepatic tissues, including nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, and uterus, but not in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus, or skeletal muscle.POLYMORPHISM The frequencies of the Cys-257 allele in white, black, Hispanic, and Asian individuals are 1.9%, 14.4%, 5.8%, and 7.7%, respectively. The Cys-257 variant is 37 to 56% less active than the wild-type Arg-257 protein toward all substrates tested.SIMILARITY Belongs to the cytochrome P450 family.ONLINE INFORMATION CYP2A13 alleles
crossReference
databaseName UniProt
dbId 52664
description
  • recommendedName: Cytochrome P450 2A13 ecNumber: 1.14.14.1 alternativeName: CYPIIA13
displayName UniProt:Q16696 CYP2A13
geneName
  • CYP2A13
identifier Q16696
isSequenceChanged false
keyword
  • 3D-structure
  • Endoplasmic reticulum
  • Heme
  • Iron
  • Membrane
  • Metal-binding
  • Microsome
  • Monooxygenase
  • Oxidoreductase
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • CYP2A13
otherIdentifier
  • 11732114_at
  • 11742251_s_at
  • 1338_s_at
  • 1552_i_at
  • 1553
  • 1553_r_at
  • 1554_f_at
  • 16862397
  • 208327_3p_at
  • 208327_PM_at
  • 208327_at
  • 3833949
  • 3833950
  • 3833951
  • 3833952
  • 3833953
  • 3833954
  • 3833955
  • 3833956
  • 3833957
  • 3833958
  • 3833959
  • 3833960
  • 3833961
  • 3833962
  • 3833963
  • 3833964
  • 3862893
  • 3862898
  • 3862900
  • 3862949
  • 3862955
  • 3862957
  • 3862958
  • 3862968
  • 3862969
  • 3862975
  • 3862978
  • 8028973
  • A_23_P55779
  • GE530746
  • GO:0004497
  • GO:0005506
  • GO:0005737
  • GO:0005783
  • GO:0005789
  • GO:0006629
  • GO:0006805
  • GO:0008389
  • GO:0008392
  • GO:0009804
  • GO:0016020
  • GO:0016491
  • GO:0016705
  • GO:0016712
  • GO:0019373
  • GO:0020037
  • GO:0046222
  • GO:0046872
  • HMNXSV003014424
  • ILMN_1651636
  • ILMN_2175455
  • PH_hs_0032038
  • TC19000572.hg
  • U22028_at
  • U22028_r_at
  • g13699808_3p_at
  • g13699808_3p_s_at
  • g13699808_3p_x_at
  • g6470138_3p_s_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • CP2AD_HUMAN
  • Q53YR8
  • Q6R569
  • Q6R570
  • Q9H2X2
sequenceLength 494
species [Species:48887] Homo sapiens
stId uniprot:Q16696
url http://purl.uniprot.org/uniprot/Q16696
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