Reactome | UniProt:Q16658 FSCN1

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UniProt:Q16658 FSCN1 Show undefined attributes

chain	initiator methionine:1 chain:2-493
checksum	C1453714BED6109A
comment	FUNCTION Actin-binding protein that contains 2 major actin binding sites (PubMed:21685497, PubMed:23184945). Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (PubMed:22155786). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:20393565, PubMed:21685497, PubMed:23184945). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (PubMed:22155786).SUBUNIT Interacts with RUFY3 (via N-terminus); the interaction induces neuron axon development (By similarity). Interacts with NGFR (By similarity). Associates with CTNNB1 (By similarity). Interacts with PLXNB3 (PubMed:21706053).INTERACTION Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity).TISSUE SPECIFICITY Ubiquitous.DOMAIN Composed of four fascin beta-trefoil domains.PTM Phosphorylation at Ser-39 inhibits actin-binding (PubMed:8647875, PubMed:8999969). Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF (PubMed:22155786).SIMILARITY Belongs to the fascin family.SEQUENCE CAUTION Extended N-terminus.
crossReference	[DatabaseIdentifier:12219522] PDB:6B0T [DatabaseIdentifier:12387549] RefSeq:NP_003079.1 [DatabaseIdentifier:12291665] Pharos - Targets:Q16658 [DatabaseIdentifier:12274490] PRO:Q16658 [DatabaseIdentifier:12219515] PDB:6I16 [DatabaseIdentifier:12219530] PDB:4GP3 [DatabaseIdentifier:12219518] PDB:6I0Z [DatabaseIdentifier:12219511] PDB:3P53 [DatabaseIdentifier:12219529] PDB:7ZAU [DatabaseIdentifier:12219519] PDB:3LLP [DatabaseIdentifier:11481326] ENSEMBL:ENSG00000075618 [DatabaseIdentifier:11582403] ENSEMBL:ENSP00000371798 [DatabaseIdentifier:11705102] ENSEMBL:ENST00000382361 [DatabaseIdentifier:11793824] GeneCards:FSCN1 [DatabaseIdentifier:11809794] GlyGen:Q16658 [DatabaseIdentifier:11846812] HPA:ENSG00000075618-FSCN1 [DatabaseIdentifier:12131474] OpenTargets:ENSG00000075618 [DatabaseIdentifier:12219535] PDB:8VO8 [DatabaseIdentifier:12219512] PDB:9GXI [DatabaseIdentifier:12219533] PDB:8VO9 [DatabaseIdentifier:12219524] PDB:8VOA [DatabaseIdentifier:12219514] PDB:6I17 [DatabaseIdentifier:12219523] PDB:6I11 [DatabaseIdentifier:12219537] PDB:8VO6 [DatabaseIdentifier:12219531] PDB:6I15 [DatabaseIdentifier:12219526] PDB:6I10 [DatabaseIdentifier:12219527] PDB:6I13 [DatabaseIdentifier:12219520] PDB:4GOY [DatabaseIdentifier:12219534] PDB:8VO7 [DatabaseIdentifier:12219521] PDB:1DFC [DatabaseIdentifier:12219532] PDB:6I14 [DatabaseIdentifier:12219517] PDB:6I18 [DatabaseIdentifier:12219513] PDB:9FN6 [DatabaseIdentifier:12219516] PDB:4GOV [DatabaseIdentifier:12219528] PDB:6I12 [DatabaseIdentifier:12219536] PDB:8VO5 [DatabaseIdentifier:12219525] PDB:4GP0
databaseName	UniProt
dbId	55004
description	recommendedName: Fascin alternativeName: 55 kDa actin-bundling protein alternativeName: Singed-like protein alternativeName: p55
displayName	UniProt:Q16658 FSCN1
geneName	FSCN1 FAN1 HSN SNL
identifier	Q16658
isSequenceChanged	false
keyword	3D-structure Acetylation Actin-binding Cell junction Cell projection Cytoplasm Cytoskeleton Direct protein sequencing Isopeptide bond Phosphoprotein Proteomics identification Reference proteome Ubl conjugation
modified	[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType	Protein
name	FSCN1
otherIdentifier	11715491_s_at 11747355_a_at 11747356_x_at 17043294 201564_PM_s_at 201564_s_at 210933_PM_s_at 210933_s_at 2988727 2988728 2988729 2988730 2988731 2988736 2988737 2988738 2988739 2988740 2988741 2988743 2988744 2988745 2988746 2988747 2988748 3588193 3588196 3588197 3588199 3588200 3588206 3588208 39070_at 6624 8131339 A_23_P168531 A_23_P168532 A_33_P3411075 GE58859 GO:0001725 GO:0001726 GO:0002102 GO:0003723 GO:0003779 GO:0005515 GO:0005737 GO:0005829 GO:0005856 GO:0005902 GO:0005911 GO:0005938 GO:0007015 GO:0007043 GO:0007163 GO:0008092 GO:0010592 GO:0015629 GO:0016477 GO:0030027 GO:0030035 GO:0030036 GO:0030046 GO:0030175 GO:0030426 GO:0030674 GO:0031252 GO:0031253 GO:0032534 GO:0032956 GO:0034330 GO:0035089 GO:0042995 GO:0043226 GO:0044393 GO:0045296 GO:0048870 GO:0051015 GO:0051017 GO:0051491 GO:0060090 GO:0070062 GO:0070161 GO:0071803 GO:0090091 HMNXSV003056688 ILMN_1808707 PH_hs_0031568 TC07000055.hg U03057_at g13436196_3p_s_at g4507114_3p_s_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-6789835] FSCN1 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000075618] ENSEMBL:ENSG00000075618 FSCN1 [ReferenceDNASequence:12693323] UCSC:Q16658 FSCN1 [ReferenceDNASequence:11346750] BioGPS Gene:6624 FSCN1 [ReferenceDNASequence:11393174] COSMIC - genes:FAN1 FSCN1 [ReferenceDNASequence:11393173] COSMIC - genes:FSCN1 FSCN1 [ReferenceDNASequence:11422433] CTD Gene:6624 FSCN1 [ReferenceDNASequence:11429112] dbSNP Gene:6624 FSCN1 [ReferenceDNASequence:11825518] HGNC:11148 FSCN1 [ReferenceDNASequence:11886857] KEGG:hsa:6624 FSCN1 [ReferenceDNASequence:11976539] Monarch:6624 FSCN1 [ReferenceDNASequence:12060632] NCBI Gene:6624 FSCN1 [ReferenceDNASequence:12115931] OMIM:602689 FSCN1
referenceTranscript	[ReferenceRNASequence:12569341] RefSeq:NM_003088.4 FSCN1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	FSCN1_HUMAN A6NI89 B2RE97 Q96IC5 Q96IH1 Q9BRF1
sequenceLength	493
species	[Species:48887] Homo sapiens
stId	uniprot:Q16658
url	http://purl.uniprot.org/uniprot/Q16658

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[EntityWithAccessionedSequence:R-HSA-6789835] FSCN1 [cytosol]

(interactor)