UniProt:Q16585 SGCB

chain
  • chain:1-318
checksum DAC5E93D1AB6C80C
comment
  • FUNCTION Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.SUBUNIT Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans (By similarity).INTERACTION Highest expression in heart and skeletal muscle. Low expression in brain, kidney, placenta, pancreas and lung. High expression in fetal brain. Also found in fetal lung, kidney and liver.PTM Disulfide bonds are present.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the sarcoglycan beta/delta/gamma/zeta family.ONLINE INFORMATION SGCB mutations in LGMD2E
crossReference
databaseName UniProt
dbId 64390
description
  • recommendedName: Beta-sarcoglycan shortName: Beta-SG alternativeName: 43 kDa dystrophin-associated glycoprotein shortName: 43DAG alternativeName: A3b
displayName UniProt:Q16585 SGCB
geneName
  • SGCB
identifier Q16585
isSequenceChanged false
keyword
  • Alternative splicing
  • Cell membrane
  • Cytoplasm
  • Cytoskeleton
  • Direct protein sequencing
  • Disease variant
  • Disulfide bond
  • Glycoprotein
  • Limb-girdle muscular dystrophy
  • Membrane
  • Proteomics identification
  • Reference proteome
  • Signal-anchor
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • SGCB
otherIdentifier
  • 11723226_at
  • 11723227_at
  • 11723228_s_at
  • 16975918
  • 205120_PM_s_at
  • 205120_s_at
  • 205121_PM_at
  • 205121_at
  • 226112_PM_at
  • 226112_at
  • 228584_PM_at
  • 228584_at
  • 2768964
  • 2768980
  • 2768982
  • 2768983
  • 2768984
  • 2768985
  • 2768986
  • 2768987
  • 2768989
  • 2768990
  • 2768991
  • 2768992
  • 2768993
  • 2768994
  • 2768995
  • 37223_at
  • 52863_at
  • 63294_at
  • 6443
  • 78662_at
  • 8100318
  • A_23_P251104
  • A_33_P3357843
  • GE59072
  • GO:0000139
  • GO:0005515
  • GO:0005737
  • GO:0005789
  • GO:0005856
  • GO:0005886
  • GO:0007517
  • GO:0009749
  • GO:0010467
  • GO:0016010
  • GO:0016011
  • GO:0016012
  • GO:0016020
  • GO:0042383
  • GO:0042593
  • GO:0044381
  • GO:0048856
  • GO:0055001
  • GO:0055013
  • GO:0055085
  • GO:0097084
  • HMNXSV003014064
  • Hs.274368.1.S1_3p_at
  • Hs.77501.1.A1_3p_at
  • ILMN_1810324
  • ILMN_2194467
  • PH_hs_0033439
  • TC04001194.hg
  • U31116_at
  • g1794188_3p_a_at
  • g4506912_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • SGCB_HUMAN
  • B7Z635
  • O00661
sequenceLength 318
species [Species:48887] Homo sapiens
stId uniprot:Q16585
url http://purl.uniprot.org/uniprot/Q16585

Referrals

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