UniProt:Q16584 MAP3K11

chain
  • chain:1-847
checksum AFB6E930EA281C15
comment
  • FUNCTION Activates the JUN N-terminal pathway. Required for serum-stimulated cell proliferation and for mitogen and cytokine activation of MAPK14 (p38), MAPK3 (ERK) and MAPK8 (JNK1) through phosphorylation and activation of MAP2K4/MKK4 and MAP2K7/MKK7. Plays a role in mitogen-stimulated phosphorylation and activation of BRAF, but does not phosphorylate BRAF directly. Influences microtubule organization during the cell cycle.CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation.SUBUNIT Homodimer; undergoes dimerization during activation (PubMed:9829970). Interacts with MAP2K4/MKK4 (By similarity). Interacts with MAP2K7/MKK7 (PubMed:9003778). Found in a complex with SH3RF1, RAC1, MAP2K7/MKK7, MAPK8IP1/JIP1 and MAPK8/JNK1 (By similarity).INTERACTION Location is cell cycle dependent.ALTERNATIVE PRODUCTS Expressed in a wide variety of normal and neoplastic tissues including fetal lung, liver, heart and kidney, and adult lung, liver, heart, kidney, placenta, skeletal muscle, pancreas and brain.PTM Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. Thr-277 is likely to be the main autophosphorylation site. Phosphorylation of Ser-555 and Ser-556 is induced by CDC42.SIMILARITY Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 236403
description
  • recommendedName: Mitogen-activated protein kinase kinase kinase 11 ecNumber: 2.7.11.25 alternativeName: Mixed lineage kinase 3 alternativeName: Src-homology 3 domain-containing proline-rich kinase
displayName UniProt:Q16584 MAP3K11
geneName
  • MAP3K11
  • MLK3
  • PTK1
  • SPRK
identifier Q16584
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • ATP-binding
  • Cytoplasm
  • Cytoskeleton
  • Kinase
  • Nucleotide-binding
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Serine/threonine-protein kinase
  • SH3 domain
  • Transferase
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • MAP3K11
otherIdentifier
  • 11719793_a_at
  • 11746632_a_at
  • 1397_at
  • 1398_g_at
  • 1558984_PM_at
  • 1558984_at
  • 16740469
  • 203652_PM_at
  • 203652_at
  • 3377753
  • 3377754
  • 3377755
  • 3377756
  • 3377757
  • 3377758
  • 3377761
  • 3377762
  • 3377763
  • 3377764
  • 3377765
  • 3377766
  • 3377767
  • 3377768
  • 3377769
  • 3377770
  • 3377771
  • 3377772
  • 3377773
  • 3377774
  • 3377775
  • 3377776
  • 3377777
  • 3377778
  • 3377779
  • 4296
  • 7949454
  • A_23_P98275
  • A_33_P3301851
  • GE63154
  • GE79298
  • GO:0000165
  • GO:0000166
  • GO:0003824
  • GO:0004672
  • GO:0004674
  • GO:0004706
  • GO:0004709
  • GO:0004713
  • GO:0005515
  • GO:0005524
  • GO:0005737
  • GO:0005813
  • GO:0005815
  • GO:0005829
  • GO:0005856
  • GO:0005874
  • GO:0006468
  • GO:0007017
  • GO:0007254
  • GO:0016020
  • GO:0016301
  • GO:0016740
  • GO:0031267
  • GO:0031434
  • GO:0031435
  • GO:0042802
  • GO:0042803
  • GO:0043065
  • GO:0043507
  • GO:0043525
  • GO:0044843
  • GO:0046330
  • GO:0046777
  • GO:0106310
  • GO:0140096
  • HMNXSV003028859
  • Hs2.432787.1.S1_3p_at
  • ILMN_1651788
  • L32976_at
  • PH_hs_0025256
  • PH_hs_0033315
  • TC11001938.hg
  • g4505194_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • M3K11_HUMAN
  • B4DS76
  • Q53H00
  • Q59F06
  • Q6P2G4
sequenceLength 847
species [Species:48887] Homo sapiens
stId uniprot:Q16584
url http://purl.uniprot.org/uniprot/Q16584
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