UniProt:Q16576 RBBP7

chain
  • initiator methionine:1
  • chain:2-425
  • initiator methionine:1
checksum 1A4B4CD1A8E96815
comment
  • FUNCTION Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.SUBUNIT Binds directly to helix 1 of the histone fold of histone H4, a region that is not accessible when H4 is in chromatin (PubMed:18571423, PubMed:9427644). Subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1 (PubMed:9427644). Subunit of the core histone deacetylase (HDAC) complex, which is composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core HDAC complex associates with SIN3A, ARID4B/SAP180, SAP18, SAP30, SAP130, SUDS3/SAP45 and possibly ARID4A/RBP1 and ING1 to form the SIN3 HDAC complex (PubMed:11118440, PubMed:11784859, PubMed:9150135, PubMed:9651585). Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:10444591, PubMed:11102443, PubMed:16428440, PubMed:28977666, PubMed:33283408, PubMed:9790534). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:16428440, PubMed:28977666, PubMed:33283408). The NuRD complex may interact with MBD3L1 (PubMed:15456747). The NuRD complex may interact with MBD3L2 (PubMed:15701600). Subunit of the PRC2/EED-EZH2 complex, which is composed of at least EED, EZH2, RBBP4, RBBP7 and SUZ12 (PubMed:12435631). The PRC2/EED-EZH2 complex may also associate with HDAC1 (PubMed:12435631). Component of the NURF-1 ISWI chromatin remodeling complex (also called the nucleosome-remodeling factor (NURF) complex) at least composed of SMARCA1 (isoform 2), BPTF, RBBP4 and RBBP7 (PubMed:14609955, PubMed:15310751). Within the complex interacts with isoform 2 of SMARCA1 (PubMed:14609955, PubMed:15310751). Component of the BPFT-SMARCA1 complex at least composed of SMARCA1 (isoform 1), BPFT, RBBP4 and RBBP7; the complex is catalytically inactive and does not remodel chromatin (PubMed:15310751). Within the complex interacts with isoform 1 of SMARCA1 (PubMed:15310751). Interacts with BRCA1 (PubMed:10220405). Interacts with CDK2AP1 (PubMed:20523938). Interacts with CENPA (PubMed:25556658). Interacts with CHD3 (PubMed:28977666). Interacts with CHD4 (PubMed:28977666). Interacts with CREBBP, and this interaction may be enhanced by the binding of phosphorylated CREB1 to CREBBP (PubMed:10866654). Interacts with HDAC7 (By similarity). Interacts with MTA1 (PubMed:12920132). Interacts with PWWP2B (By similarity). Interacts with RB1 (via viral protein-binding domain) (PubMed:10220405, PubMed:7503932). Interacts with SUV39H1 (By similarity).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.
crossReference
databaseName UniProt
dbId 62840
description
  • recommendedName: Histone-binding protein RBBP7 alternativeName: Histone acetyltransferase type B subunit 2 alternativeName: Nucleosome-remodeling factor subunit RBAP46 alternativeName: Retinoblastoma-binding protein 7 shortName: RBBP-7 alternativeName: Retinoblastoma-binding protein p46
displayName UniProt:Q16576 RBBP7
geneName
  • RBBP7
  • RBAP46
identifier Q16576
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Chaperone
  • Chromatin regulator
  • Direct protein sequencing
  • DNA replication
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Repressor
  • Transcription
  • Transcription regulation
  • Ubl conjugation
  • WD repeat
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • RBBP7
otherIdentifier
  • 11715433_a_at
  • 17109396
  • 201092_PM_at
  • 201092_at
  • 3981265
  • 4000945
  • 4000946
  • 4000947
  • 4000948
  • 4000949
  • 4000950
  • 4000951
  • 4000952
  • 4000953
  • 4000955
  • 4000956
  • 4000957
  • 4000958
  • 4000959
  • 4000960
  • 4000961
  • 4000962
  • 4000963
  • 4000966
  • 4000967
  • 4000968
  • 4000970
  • 4000972
  • 4000973
  • 4000974
  • 4000975
  • 4000976
  • 4000977
  • 4000978
  • 4000979
  • 41515_at
  • 5931
  • 8171516
  • A_23_P114221
  • GE59981
  • GO:0000118
  • GO:0000122
  • GO:0000781
  • GO:0003723
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005829
  • GO:0006260
  • GO:0006325
  • GO:0006338
  • GO:0006355
  • GO:0007420
  • GO:0016581
  • GO:0016589
  • GO:0030308
  • GO:0030336
  • GO:0030512
  • GO:0035098
  • GO:0042393
  • GO:0042659
  • GO:0045892
  • GO:0045893
  • GO:0048545
  • GO:0048856
  • GO:0070370
  • GO:0070822
  • GO:1902455
  • GO:1902459
  • GO:1904949
  • GO:2000736
  • HMNXSV003057994
  • ILMN_1770053
  • PH_hs_0019247
  • TC0X000886.hg
  • X72841_at
  • g13259504_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RBBP7_HUMAN
  • Q5JP00
sequenceLength 425
species [Species:48887] Homo sapiens
stId uniprot:Q16576
url http://purl.uniprot.org/uniprot/Q16576

Referrals

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