Reactome | UniProt:Q16553 LY6E

chain	signal peptide:1-20 chain:21-101 propeptide:102-131
checksum	0F6D1157741AFC98
comment	FUNCTION GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482). Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity).FUNCTION (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus (PubMed:28130445). In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E (PubMed:28130445, PubMed:29610346). Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape (PubMed:28130445, PubMed:30190477).SUBUNIT Interacts with CHRNA4.INTERACTION Widely expressed, predominantly in liver, kidney, ovary, spleen and peripheral blood Leukocytes.INDUCTION By retinoic acid; in promyelocytic leukemia NB4 and in myeloblast HL-60 cell lines. Activated by IFN-alpha in monocytic cell line U-937 and in peripheral blood monocyte cells.
crossReference	[DatabaseIdentifier:11810397] GlyGen:Q16553 [DatabaseIdentifier:12389192] RefSeq:NP_001120685.1 [DatabaseIdentifier:12389193] RefSeq:NP_002337.1 [DatabaseIdentifier:12292286] Pharos - Targets:Q16553 [DatabaseIdentifier:12275269] PRO:Q16553 [DatabaseIdentifier:12132102] OpenTargets:ENSG00000160932 [DatabaseIdentifier:11847427] HPA:ENSG00000160932-LY6E [DatabaseIdentifier:11482047] ENSEMBL:ENSG00000160932 [DatabaseIdentifier:11482048] ENSEMBL:ENSG00000278032 [DatabaseIdentifier:11583443] ENSEMBL:ENSP00000488421 [DatabaseIdentifier:11583440] ENSEMBL:ENSP00000428427 [DatabaseIdentifier:11583450] ENSEMBL:ENSP00000488559 [DatabaseIdentifier:11583449] ENSEMBL:ENSP00000428159 [DatabaseIdentifier:11583441] ENSEMBL:ENSP00000427915 [DatabaseIdentifier:11583444] ENSEMBL:ENSP00000488443 [DatabaseIdentifier:11583454] ENSEMBL:ENSP00000414307 [DatabaseIdentifier:11583448] ENSEMBL:ENSP00000488556 [DatabaseIdentifier:11583452] ENSEMBL:ENSP00000292494 [DatabaseIdentifier:11583445] ENSEMBL:ENSP00000428442 [DatabaseIdentifier:11583447] ENSEMBL:ENSP00000428572 [DatabaseIdentifier:11583453] ENSEMBL:ENSP00000487664 [DatabaseIdentifier:11583446] ENSEMBL:ENSP00000482517 [DatabaseIdentifier:11583442] ENSEMBL:ENSP00000488891 [DatabaseIdentifier:11583451] ENSEMBL:ENSP00000428169 [DatabaseIdentifier:11706146] ENSEMBL:ENST00000619718 [DatabaseIdentifier:11706153] ENSEMBL:ENST00000517503 [DatabaseIdentifier:11706152] ENSEMBL:ENST00000631568 [DatabaseIdentifier:11706151] ENSEMBL:ENST00000632812 [DatabaseIdentifier:11706147] ENSEMBL:ENST00000429120 [DatabaseIdentifier:11706144] ENSEMBL:ENST00000633451 [DatabaseIdentifier:11706141] ENSEMBL:ENST00000292494 [DatabaseIdentifier:11706148] ENSEMBL:ENST00000632519 [DatabaseIdentifier:11706143] ENSEMBL:ENST00000521003 [DatabaseIdentifier:11706142] ENSEMBL:ENST00000520466 [DatabaseIdentifier:11706150] ENSEMBL:ENST00000521699 [DatabaseIdentifier:11706140] ENSEMBL:ENST00000522971 [DatabaseIdentifier:11706149] ENSEMBL:ENST00000632516 [DatabaseIdentifier:11706139] ENSEMBL:ENST00000632424 [DatabaseIdentifier:11706145] ENSEMBL:ENST00000522024 [DatabaseIdentifier:11794453] GeneCards:LY6E
databaseName	UniProt
dbId	58833
description	recommendedName: fullName evidence="9"Lymphocyte antigen 6E shortName: Ly-6E alternativeName: Retinoic acid-induced gene E protein shortName: RIG-E alternativeName: Stem cell antigen 2 shortName: SCA-2 alternativeName: Thymic shared antigen 1 shortName: TSA-1
displayName	UniProt:Q16553 LY6E
geneName	LY6E 9804 RIGE SCA2 TSA1
identifier	Q16553
isSequenceChanged	false
keyword	Cell membrane Disulfide bond Glycoprotein GPI-anchor Host-virus interaction Lipoprotein Membrane Proteomics identification Reference proteome Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	LY6E
otherIdentifier	11715419_at 17073259 202145_PM_at 202145_at 3119346 3119347 3119348 3119349 3119350 3119351 3119352 3119353 3119354 3119355 3119356 3119357 3119358 3119359 3119361 3119362 3119363 3119365 37360_at 4061 8148572 A_14_P121295 A_24_P317762 GE59344 GO:0005515 GO:0005576 GO:0005886 GO:0007166 GO:0016020 GO:0030550 GO:0033130 GO:0045202 GO:0046597 GO:0095500 GO:0098552 GO:0098772 ILMN_1695404 PH_hs_0004480 TC08000814.hg U66711_rna1_s_at g4505048_3p_at g4505048_3p_x_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-8940767] GPI-LY6E [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8941061] cleaved GPI-LY6E [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000160932] ENSEMBL:ENSG00000160932 LY6E [ReferenceDNASequence:12693907] UCSC:Q16553 LY6E [ReferenceDNASequence:12116496] OMIM:601384 LY6E [ReferenceDNASequence:12061382] NCBI Gene:4061 LY6E [ReferenceDNASequence:11977289] Monarch:4061 LY6E [ReferenceDNASequence:11887522] KEGG:hsa:4061 LY6E [ReferenceDNASequence:11826150] HGNC:6727 LY6E [ReferenceDNASequence:11347500] BioGPS Gene:4061 LY6E [ReferenceDNASequence:11393237] COSMIC - genes:LY6E LY6E [ReferenceDNASequence:11423212] CTD Gene:4061 LY6E [ReferenceDNASequence:11429174] dbSNP Gene:4061 LY6E
referenceTranscript	[ReferenceRNASequence:12570962] RefSeq:NM_001127213.2 LY6E [ReferenceRNASequence:12570963] RefSeq:NM_002346.3 LY6E
schemaClass	ReferenceGeneProduct
secondaryIdentifier	LY6E_HUMAN B2R4X5 D3DWJ2 Q0VDE5
sequenceLength	131
species	[Species:48887] Homo sapiens
stId	uniprot:Q16553
url	http://purl.uniprot.org/uniprot/Q16553

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-8940767] GPI-LY6E [plasma membrane] [EntityWithAccessionedSequence:R-HSA-8941061] cleaved GPI-LY6E [extracellular region]
(referenceSequence)	[GroupModifiedResidue:8940799] L-serine amide (GPI-anchor amidated amino acid carboxyl end residue(1?)) at 101 [GroupModifiedResidue:8941064] L-serine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 101
(interactor)	[UndirectedInteraction:11251125] UniProt:Q16553 <-> UniProt:P0DTD1-PRO_0000449624 (IntAct) [UndirectedInteraction:11251127] UniProt:Q16553 <-> UniProt:Q9NV12 (IntAct) [UndirectedInteraction:11251129] UniProt:Q16553 <-> UniProt:A5PKU2 (IntAct) [UndirectedInteraction:11251131] UniProt:Q16553 <-> UniProt:Q6ZSS7 (IntAct) [UndirectedInteraction:11251133] UniProt:Q16553 <-> UniProt:Q96HH6 (IntAct)

UniProt:Q16553 LY6E Show undefined attributes

Referrals