UniProt:Q16537 PPP2R5E

chain
  • initiator methionine:1
  • chain:2-467
checksum DD9CE11433F499CF
comment
  • FUNCTION The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment.SUBUNIT Found in a complex with at least ARL2, PPP2CB; PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1.INTERACTION Phosphorylated on serine residues.SIMILARITY Belongs to the phosphatase 2A regulatory subunit B56 family.
crossReference
databaseName UniProt
dbId 49121
description
  • recommendedName: Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform alternativeName: PP2A B subunit isoform B'-epsilon alternativeName: PP2A B subunit isoform B56-epsilon alternativeName: PP2A B subunit isoform PR61-epsilon alternativeName: PP2A B subunit isoform R5-epsilon
displayName UniProt:Q16537 PPP2R5E
geneName
  • PPP2R5E
identifier Q16537
isSequenceChanged false
keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cytoplasm
  • Direct protein sequencing
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
modified [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
moleculeType Protein
name
  • PPP2R5E
otherIdentifier
  • 11730271_at
  • 11730272_a_at
  • 11748296_a_at
  • 11748297_s_at
  • 11759023_at
  • 11759024_at
  • 11759025_s_at
  • 16793721
  • 203338_PM_at
  • 203338_at
  • 227630_PM_at
  • 227630_at
  • 228070_PM_at
  • 228070_at
  • 229322_PM_at
  • 229322_at
  • 2361184
  • 3051984
  • 3051987
  • 3051990
  • 3051991
  • 3051992
  • 32734_at
  • 3567985
  • 3567986
  • 3567987
  • 3567988
  • 3567989
  • 3567990
  • 3567992
  • 3567993
  • 3567994
  • 3567995
  • 3567996
  • 3567997
  • 3567998
  • 3568005
  • 3568009
  • 3568017
  • 3568018
  • 3568019
  • 3568035
  • 3568036
  • 3568037
  • 3568038
  • 3568039
  • 3568040
  • 3568041
  • 3568049
  • 3568050
  • 3568051
  • 53735_at
  • 5529
  • 56629_at
  • 56638_g_at
  • 76264_at
  • 7979551
  • A_23_P3042
  • A_24_P5026
  • GE57793
  • GO:0000159
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005829
  • GO:0007165
  • GO:0019888
  • GO:0072542
  • GO:0098772
  • HMNXSV003032848
  • Hs.122684.1.S1_3p_at
  • Hs.283362.0.A1_3p_at
  • Hs.319817.0.A1_3p_at
  • ILMN_1666761
  • L76703_at
  • PH_hs_0027933
  • TC14001206.hg
  • g5453955_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • 2A5E_HUMAN
  • A4FU37
  • B7ZAW5
  • B7ZKK8
  • B7ZKK9
  • J3KQN6
  • Q52LW4
sequenceLength 467
species [Species:48887] Homo sapiens
stId uniprot:Q16537
url http://purl.uniprot.org/uniprot/Q16537
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