UniProt:Q16520 BATF

chain
  • chain:1-125
checksum 7FD633C6F1963DF4
comment
  • FUNCTION AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination (CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region (I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells (HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs (By similarity).SUBUNIT Heterodimer; mainly heterodimerizes with JUNB. The BATF-JUNB heterodimer interacts with IRF4 and IRF8. Interacts (via bZIP domain) with IRF4 and IRF8; the interaction is direct (By similarity). Also forms heterodimers with JUN and JUND. Also interacts with IFI35.INTERACTION Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells.TISSUE SPECIFICITY Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209).INDUCTION Up-regulated by PDCD1 following infection by HIV-1 virus, leading to inhibit T-cell functions and exhaust T-cells. Up-regulated by Epstein-Barr virus (EBV) protein EBNA2 following infection by EBV.PTM Phosphorylated on serine and threonine residues and at least one tyrosine residue. Phosphorylation at Ser-43 inhibit DNA binding activity and transforms it as a negative regulator of AP-1 mediated transcription (By similarity).PTM Phosphorylated.SIMILARITY Belongs to the bZIP family.
crossReference
databaseName UniProt
dbId 85816
description
  • recommendedName: Basic leucine zipper transcriptional factor ATF-like alternativeName: B-cell-activating transcription factor shortName: B-ATF alternativeName: SF-HT-activated gene 2 protein shortName: SFA-2
displayName UniProt:Q16520 BATF
geneName
  • BATF
identifier Q16520
isSequenceChanged false
keyword
  • Activator
  • Cytoplasm
  • Differentiation
  • DNA-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repressor
  • Transcription
  • Transcription regulation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • BATF
otherIdentifier
  • 10538
  • 11724374_at
  • 16786616
  • 205965_PM_at
  • 205965_at
  • 3194908
  • 3544611
  • 3544612
  • 3544613
  • 3544616
  • 3544622
  • 3544623
  • 3544624
  • 39942_at
  • 7975793
  • A_23_P128974
  • GE54141
  • GO:0000785
  • GO:0000978
  • GO:0000981
  • GO:0001228
  • GO:0001819
  • GO:0002320
  • GO:0002376
  • GO:0003677
  • GO:0003700
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005737
  • GO:0006310
  • GO:0006355
  • GO:0006357
  • GO:0006974
  • GO:0030154
  • GO:0030330
  • GO:0042832
  • GO:0043011
  • GO:0043565
  • GO:0045064
  • GO:0045190
  • GO:0045944
  • GO:0060218
  • GO:0072539
  • GO:0072540
  • GO:0090575
  • GO:0098542
  • GO:0140467
  • GO:1990837
  • GO:2000319
  • HMNXSV003005221
  • ILMN_1668822
  • TC14000474.hg
  • U15460_at
  • g5453562_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • BATF_HUMAN
sequenceLength 125
species [Species:48887] Homo sapiens
stId uniprot:Q16520
url http://purl.uniprot.org/uniprot/Q16520

Referrals

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