UniProt:Q16270 IGFBP7

chain
  • signal peptide:1-26
  • chain:27-282
checksum 75F96EBC3B444D37
comment
  • FUNCTION Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis (PubMed:38218180).SUBUNIT May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear. Interacts with CD93; this interaction plays a role in endothelial cells angiogenesis (PubMed:38218180).SUBCELLULAR LOCATION N-glycosylated.RNA EDITING Partially edited. In the brain, position 78 is edited at about 55% and position 95 at about 31%.DISEASE The disease is caused by variants affecting the gene represented in this entry.
crossReference
databaseName UniProt
dbId 57000
description
  • recommendedName: Insulin-like growth factor-binding protein 7 shortName: IBP-7 shortName: IGF-binding protein 7 shortName: IGFBP-7 alternativeName: IGFBP-rP1 alternativeName: MAC25 protein alternativeName: PGI2-stimulating factor alternativeName: Prostacyclin-stimulating factor alternativeName: Tumor-derived adhesion factor shortName: TAF
displayName UniProt:Q16270 IGFBP7
geneName
  • IGFBP7
  • MAC25
  • PSF
identifier Q16270
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell adhesion
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Growth factor binding
  • Immunoglobulin domain
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • RNA editing
  • Secreted
  • Signal
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • IGFBP7
otherIdentifier
  • 11715501_s_at
  • 11758721_s_at
  • 11760203_x_at
  • 16976211
  • 201162_PM_at
  • 201162_at
  • 201163_PM_s_at
  • 201163_s_at
  • 2062_at
  • 2770470
  • 2770471
  • 2770472
  • 2770473
  • 2770474
  • 2770475
  • 2770477
  • 2770482
  • 2770483
  • 2770500
  • 2770501
  • 2770530
  • 2770531
  • 2770532
  • 2770533
  • 3490
  • 8100541
  • A_23_P255111
  • A_23_P353035
  • GE81041
  • GO:0001525
  • GO:0001558
  • GO:0005198
  • GO:0005201
  • GO:0005515
  • GO:0005520
  • GO:0005576
  • GO:0005615
  • GO:0005788
  • GO:0007155
  • GO:0007165
  • GO:0007566
  • GO:0008285
  • GO:0009966
  • GO:0019838
  • GO:0022414
  • GO:0030312
  • GO:0031012
  • GO:0032526
  • GO:0032870
  • GO:0048018
  • GO:0050810
  • GO:0051414
  • GO:0070062
  • GO:0071380
  • GO:0098772
  • HMNXSV003002427
  • HMNXSV003025935
  • HMNXSV003056442
  • ILMN_2062468
  • PH_hs_0025441
  • TC04001226.hg
  • TC04002560.hg
  • g4504618_3p_a_at
  • p12307
  • p12308
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • IBP7_HUMAN
  • B4E1N2
  • B7Z9W7
  • Q07822
  • Q53YE6
  • Q9UCA8
sequenceLength 282
species [Species:48887] Homo sapiens
stId uniprot:Q16270
url http://purl.uniprot.org/uniprot/Q16270
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