UniProt:Q15768 EFNB3

chain
  • signal peptide:1-27
  • chain:28-340
checksum EDFF2A23C2FDE79F
comment
  • FUNCTION Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons (By similarity).FUNCTION (Microbial infection) Acts as a receptor for nipah virus and hendra virus.SUBUNIT Interacts with GRIP1 and GRIP2.SUBUNIT (Microbial infection) Interacts with nipah virus and hendra virus glycoprotein (PubMed:16477309, PubMed:17376907).INTERACTION Highly expressed in brain; expressed in embryonic floor plate, roof plate and hindbrain segments.SIMILARITY Belongs to the ephrin family.
crossReference
databaseName UniProt
dbId 54194
description
  • recommendedName: Ephrin-B3 alternativeName: EPH-related receptor transmembrane ligand ELK-L3 alternativeName: EPH-related receptor tyrosine kinase ligand 8 shortName: LERK-8
displayName UniProt:Q15768 EFNB3
geneName
  • EFNB3
  • EPLG8
  • LERK8
identifier Q15768
isSequenceChanged false
keyword
  • 3D-structure
  • Developmental protein
  • Differentiation
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Host cell receptor for virus entry
  • Host-virus interaction
  • Membrane
  • Methylation
  • Neurogenesis
  • Phosphoprotein
  • Proteomics identification
  • Receptor
  • Reference proteome
  • Signal
  • Transmembrane
  • Transmembrane helix
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • EFNB3
otherIdentifier
  • 11722318_a_at
  • 11722319_a_at
  • 11722320_a_at
  • 16830653
  • 1949
  • 205031_PM_at
  • 205031_at
  • 210883_PM_x_at
  • 210883_x_at
  • 3708992
  • 3708993
  • 3708995
  • 3708997
  • 3708998
  • 3708999
  • 3709001
  • 3709002
  • 3709003
  • 3709004
  • 3709005
  • 3709006
  • 3709007
  • 469_at
  • 8004571
  • A_14_P104467
  • A_23_P433588
  • A_24_P940006
  • GE59333
  • GE890359
  • GO:0001618
  • GO:0002376
  • GO:0003824
  • GO:0005005
  • GO:0005515
  • GO:0005886
  • GO:0007267
  • GO:0007399
  • GO:0007411
  • GO:0007628
  • GO:0016020
  • GO:0016198
  • GO:0016740
  • GO:0030154
  • GO:0031295
  • GO:0042734
  • GO:0046718
  • GO:0046875
  • GO:0048013
  • GO:0048856
  • GO:0050771
  • GO:0098686
  • GO:0098978
  • GO:0099557
  • GO:0140096
  • HMNXSV003036717
  • ILMN_1695606
  • PH_hs_0031106
  • TC17000114.hg
  • U66406_at
  • g1469781_3p_a_at
  • g4503488_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • EFNB3_HUMAN
  • B2RBW2
  • D3DTQ6
  • O00680
  • Q8TBH7
  • Q92875
sequenceLength 340
species [Species:48887] Homo sapiens
stId uniprot:Q15768
url http://purl.uniprot.org/uniprot/Q15768
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