Reactome | UniProt:Q15648 MED1

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UniProt:Q15648 MED1 Show undefined attributes

chain	chain:1-1581
checksum	FCE0FE87EF08B887
comment	FUNCTION Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (PubMed:10406464, PubMed:11867769, PubMed:12037571, PubMed:12218053, PubMed:12556447, PubMed:14636573, PubMed:15340084, PubMed:15471764, PubMed:15989967, PubMed:16574658, PubMed:9653119). Acts as a coactivator for GATA1-mediated transcriptional activation during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).SUBUNIT Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. This subunit specifically interacts with a number of nuclear receptors in a ligand-dependent fashion including AR, ESR1, ESR2, PPARA, PPARG, RORA, RXRA, RXRG, THRA, THRB and VDR. Interacts with CTNNB1, GABPA, GLI3, PPARGC1A and TP53. Interacts with YWHAH. Interacts with CLOCK; this interaction requires the presence of THRAP3 (By similarity). Interacts with GATA1 and CCAR1. Interacts with NR4A3 (By similarity). Interacts (via IBM motif) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (PubMed:29997176). Interacts with USP22 (By similarity). Interacts with PRDM16; promoting recruitment of the Mediator complex to chromatin and activation of genes that are highly expressed in brown adipocytes (By similarity).INTERACTION A subset of the protein may enter the nucleolus subsequent to phosphorylation by MAPK1 or MAPK3.ALTERNATIVE PRODUCTS Ubiquitously expressed.PTM Phosphorylated by MAPK1 or MAPK3 during G2/M phase which may enhance protein stability and promote entry into the nucleolus (PubMed:16314496). Phosphorylation increases its interaction with PSIP1 (PubMed:29997176).SIMILARITY Belongs to the Mediator complex subunit 1 family.SEQUENCE CAUTION Contaminating sequence. Potential poly-A sequence.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference	[DatabaseIdentifier:11504024] ENSEMBL:ENSG00000125686 [DatabaseIdentifier:12437360] RefSeq:NP_004765.2 [DatabaseIdentifier:12294887] Pharos - Targets:Q15648 [DatabaseIdentifier:12257471] PRO:Q15648 [DatabaseIdentifier:12157418] PDB:3A2H [DatabaseIdentifier:12157414] PDB:5GIE [DatabaseIdentifier:12172931] PDB:6D94 [DatabaseIdentifier:12157415] PDB:3W5Q [DatabaseIdentifier:12139979] PDB:8TRH [DatabaseIdentifier:12157411] PDB:1RJK [DatabaseIdentifier:12157412] PDB:5GIC [DatabaseIdentifier:12157417] PDB:3W5T [DatabaseIdentifier:12157420] PDB:5AWJ [DatabaseIdentifier:12139984] PDB:8T9D [DatabaseIdentifier:12139980] PDB:7ENC [DatabaseIdentifier:12157404] PDB:5ZWF [DatabaseIdentifier:12157428] PDB:3WT6 [DatabaseIdentifier:12157416] PDB:3W5R [DatabaseIdentifier:12157406] PDB:5ZWI [DatabaseIdentifier:12157422] PDB:7C7V [DatabaseIdentifier:12157379] PDB:5XZF [DatabaseIdentifier:12139976] PDB:8GXS [DatabaseIdentifier:12139977] PDB:8GXQ [DatabaseIdentifier:12139975] PDB:7ENJ [DatabaseIdentifier:12157392] PDB:7VQP [DatabaseIdentifier:12172907] PDB:6ONJ [DatabaseIdentifier:12216022] PDB:7OXU [DatabaseIdentifier:12157381] PDB:4YNK [DatabaseIdentifier:12139978] PDB:8TQW [DatabaseIdentifier:12157377] PDB:2O4R [DatabaseIdentifier:12157410] PDB:5GID [DatabaseIdentifier:12157399] PDB:1RKH [DatabaseIdentifier:12157413] PDB:6K5O [DatabaseIdentifier:12157401] PDB:5ZWE [DatabaseIdentifier:12139982] PDB:7ENA [DatabaseIdentifier:12157373] PDB:5XZH [DatabaseIdentifier:12157419] PDB:1RK3 [DatabaseIdentifier:12157400] PDB:1RKG [DatabaseIdentifier:12157430] PDB:3WT7 [DatabaseIdentifier:12157424] PDB:7C7W [DatabaseIdentifier:12157408] PDB:5ZWH [DatabaseIdentifier:12157426] PDB:3WT5 [DatabaseIdentifier:12157423] PDB:5B41 [DatabaseIdentifier:12157366] PDB:3VRU [DatabaseIdentifier:12157351] PDB:5XUQ [DatabaseIdentifier:12139983] PDB:7EMF [DatabaseIdentifier:12157367] PDB:3AUN [DatabaseIdentifier:12157360] PDB:5XPP [DatabaseIdentifier:12157359] PDB:5XPM [DatabaseIdentifier:12157365] PDB:3VRT [DatabaseIdentifier:12157372] PDB:3W5P [DatabaseIdentifier:12157346] PDB:3W0G [DatabaseIdentifier:12157350] PDB:3W0J [DatabaseIdentifier:12157354] PDB:3VJS [DatabaseIdentifier:12157353] PDB:6JEZ [DatabaseIdentifier:12157358] PDB:5AWK [DatabaseIdentifier:12157357] PDB:3WTQ [DatabaseIdentifier:12157348] PDB:3W0H [DatabaseIdentifier:12157371] PDB:2O4J [DatabaseIdentifier:12157369] PDB:2ZFX [DatabaseIdentifier:12157368] PDB:3VRV [DatabaseIdentifier:12157355] PDB:3VJT [DatabaseIdentifier:12157349] PDB:3W0I [DatabaseIdentifier:12157362] PDB:5XPO [DatabaseIdentifier:12157347] PDB:5B5B [DatabaseIdentifier:12157352] PDB:3VRW [DatabaseIdentifier:12157356] PDB:5XPN [DatabaseIdentifier:12134725] OpenTargets:ENSG00000125686 [DatabaseIdentifier:11850023] HPA:ENSG00000125686-MED1 [DatabaseIdentifier:11812890] GlyGen:Q15648 [DatabaseIdentifier:11797056] GeneCards:MED1 [DatabaseIdentifier:11738588] ENSEMBL:ENST00000300651 [DatabaseIdentifier:11738587] ENSEMBL:ENST00000394287 [DatabaseIdentifier:11615889] ENSEMBL:ENSP00000300651 [DatabaseIdentifier:11615888] ENSEMBL:ENSP00000377828
databaseName	UniProt
dbId	405875
description	recommendedName: Mediator of RNA polymerase II transcription subunit 1 alternativeName: Activator-recruited cofactor 205 kDa component shortName: ARC205 alternativeName: Mediator complex subunit 1 alternativeName: Peroxisome proliferator-activated receptor-binding protein shortName: PBP shortName: PPAR-binding protein alternativeName: Thyroid hormone receptor-associated protein complex 220 kDa component shortName: Trap220 alternativeName: Thyroid receptor-interacting protein 2 shortName: TR-interacting protein 2 shortName: TRIP-2 alternativeName: Vitamin D receptor-interacting protein complex component DRIP205 alternativeName: p53 regulatory protein RB18A
displayName	UniProt:Q15648 MED1
geneName	MED1 ARC205 CRSP1 CRSP200 DRIP205 DRIP230 PBP PPARBP PPARGBP RB18A TRAP220 TRIP2
identifier	Q15648
isSequenceChanged	false
keyword	3D-structure Acetylation Activator Alternative splicing Direct protein sequencing DNA-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation
modified	[InstanceEdit:9983091] Weiser, Joel, 2026-02-20
moleculeType	Protein
name	MED1
otherIdentifier	11721007_a_at 11721008_a_at 11721009_at 16844155 203496_PM_s_at 203496_s_at 203497_PM_at 203497_at 225452_PM_at 225452_at 225456_PM_at 225456_at 32064_at 3755697 3755698 3755699 3755700 3755701 3755702 3755716 3755717 3755718 3755719 3755720 3755721 3755722 3755723 3755724 3755725 3755727 3755728 3755729 3755730 3755731 3755732 3755733 3755734 3755735 3755736 3755737 3755738 3755740 3755741 3755742 3755743 3755744 3755745 3755748 3755749 3755750 44549_at 5469 56136_at 8014841 A_23_P15314 A_23_P425704 A_24_P940666 A_33_P3210423 GE86426 GO:0000122 GO:0000151 GO:0000785 GO:0000902 GO:0000978 GO:0001223 GO:0001525 GO:0001701 GO:0001889 GO:0001892 GO:0002088 GO:0002154 GO:0003222 GO:0003406 GO:0003677 GO:0003682 GO:0003712 GO:0003713 GO:0003714 GO:0003824 GO:0005515 GO:0005634 GO:0005654 GO:0005730 GO:0006351 GO:0006355 GO:0006357 GO:0006575 GO:0006590 GO:0006606 GO:0006629 GO:0006702 GO:0006886 GO:0006913 GO:0007420 GO:0007507 GO:0007595 GO:0008284 GO:0009887 GO:0010628 GO:0010839 GO:0016020 GO:0016071 GO:0016567 GO:0016592 GO:0016740 GO:0016922 GO:0022414 GO:0030154 GO:0030216 GO:0030224 GO:0030331 GO:0030518 GO:0031100 GO:0031490 GO:0032968 GO:0032993 GO:0033148 GO:0033598 GO:0035035 GO:0035050 GO:0035116 GO:0035162 GO:0035357 GO:0035729 GO:0035855 GO:0042789 GO:0042809 GO:0042974 GO:0042975 GO:0043010 GO:0043066 GO:0044877 GO:0045023 GO:0045444 GO:0045618 GO:0045648 GO:0045665 GO:0045893 GO:0045944 GO:0046966 GO:0048821 GO:0048822 GO:0048856 GO:0050693 GO:0051123 GO:0060218 GO:0060261 GO:0060335 GO:0060744 GO:0060745 GO:0060750 GO:0061629 GO:0061630 GO:0065003 GO:0070318 GO:0070562 GO:0070847 GO:0071364 GO:0071383 GO:0097067 GO:0140096 GO:0140296 GO:0140297 GO:1990841 GO:2000347 GO:2001141 HMNXSV003029846 HMNXSV003047175 Hs.10130.0.A1_3p_at Hs.10130.0.A2_3p_at ILMN_1721729 L40366_at PH_hs_0001448 TC17001449.hg TC17002613.hg g3319289_3p_a_at g4759265_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-212445] MED1 [nucleoplasm] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000125686] ENSEMBL:ENSG00000125686 MED1 [ReferenceDNASequence:12759420] UCSC:Q15648 MED1 [ReferenceDNASequence:12118867] OMIM:604311 MED1 [ReferenceDNASequence:12083549] NCBI Gene:5469 MED1 [ReferenceDNASequence:11999456] Monarch:5469 MED1 [ReferenceDNASequence:11907858] KEGG:hsa:5469 MED1 [ReferenceDNASequence:11828772] HGNC:9234 MED1 [ReferenceDNASequence:11439816] dbSNP Gene:5469 MED1 [ReferenceDNASequence:11426467] CTD Gene:5469 MED1 [ReferenceDNASequence:11398403] COSMIC - genes:MED1 MBD4 [ReferenceDNASequence:11369667] BioGPS Gene:5469 MED1
referenceTranscript	[ReferenceRNASequence:12618875] RefSeq:NM_004774.3 MED1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	MED1_HUMAN A2RRQ6 O43810 O75447 Q6P9H7 Q6PK58 Q9HD39
sequenceLength	1581
species	[Species:48887] Homo sapiens
stId	uniprot:Q15648
url	http://purl.uniprot.org/uniprot/Q15648

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[EntityWithAccessionedSequence:R-HSA-212445] MED1 [nucleoplasm]

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