UniProt:Q15398 DLGAP5

chain
  • chain:1-846
checksum 588BAF238D6FFB72
comment
  • FUNCTION Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.SUBUNIT Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1.INTERACTION Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.ALTERNATIVE PRODUCTS Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.DEVELOPMENTAL STAGE Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells.PTM Ubiquitinated, leading to its degradation.PTM Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.SIMILARITY Belongs to the SAPAP family.CAUTION It was localized to the spindle and the spindle pole (PubMed:12527899) but was later found to be localized to the spindle and to be excluded from the spindle pole (PubMed:15561729).SEQUENCE CAUTION Extended N-terminus.SEQUENCE CAUTION Extended N-terminus.
crossReference
databaseName UniProt
dbId 67464
description
  • recommendedName: Disks large-associated protein 5 shortName: DAP-5 alternativeName: Discs large homolog 7 alternativeName: Disks large-associated protein DLG7 alternativeName: Hepatoma up-regulated protein shortName: HURP
displayName UniProt:Q15398 DLGAP5
geneName
  • DLGAP5
  • DLG7
  • KIAA0008
identifier Q15398
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Cell cycle
  • Coiled coil
  • Cytoplasm
  • Cytoskeleton
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Ubl conjugation
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • DLGAP5
otherIdentifier
  • 11722367_a_at
  • 11744793_x_at
  • 16793225
  • 203764_PM_at
  • 203764_at
  • 3565671
  • 3565672
  • 3565675
  • 3565677
  • 3565678
  • 3565679
  • 3565680
  • 3565681
  • 3565683
  • 3565684
  • 3565685
  • 3565686
  • 3565687
  • 3565688
  • 3565689
  • 3565690
  • 3565691
  • 3565692
  • 3565693
  • 3565694
  • 3565695
  • 3565696
  • 3565697
  • 3565698
  • 3565699
  • 3565700
  • 3565701
  • 3565702
  • 37231_at
  • 7979307
  • 9787
  • A_23_P88331
  • D13633_at
  • GE57064
  • GO:0005515
  • GO:0005634
  • GO:0005737
  • GO:0005815
  • GO:0005819
  • GO:0005829
  • GO:0005856
  • GO:0007010
  • GO:0007018
  • GO:0007052
  • GO:0007059
  • GO:0007079
  • GO:0007346
  • GO:0008017
  • GO:0008092
  • GO:0023052
  • GO:0031616
  • GO:0043226
  • GO:0045842
  • GO:0051382
  • GO:0051642
  • GO:0065003
  • GO:0072686
  • HMNXSV003027914
  • ILMN_1749829
  • PH_hs_0004483
  • TC14001155.hg
  • g7661851_3p_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • DLGP5_HUMAN
  • A8MTM6
  • B4DRM8
  • Q86T11
  • Q8NG58
sequenceLength 846
species [Species:48887] Homo sapiens
stId uniprot:Q15398
url http://purl.uniprot.org/uniprot/Q15398
Cite Us!