Reactome | UniProt:Q15389 ANGPT1

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UniProt:Q15389 ANGPT1 Show undefined attributes

chain	signal peptide:1-15 chain:16-498
checksum	5D5FA63AEF6BE920
comment	FUNCTION Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.SUBUNIT Homooligomer (PubMed:28601681). Interacts with TEK/TIE2 (PubMed:28601681, PubMed:30689269). Interacts with SVEP1/polydom (By similarity). Interacts with THBD; this interaction significantly inhibits the generation of activated PC and TAFIa/CPB2 by the thrombin/thrombomodulin complex (PubMed:29323190).INTERACTION Glycosylated.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.SEQUENCE CAUTION Angiopoietin entry
crossReference	[DatabaseIdentifier:12290854] Pharos - Targets:Q15389 [DatabaseIdentifier:12252878] PRO:Q15389 [DatabaseIdentifier:12155267] PDB:4K0V [DatabaseIdentifier:12215973] PDB:9IVU [DatabaseIdentifier:12215974] PDB:9IVT [DatabaseIdentifier:12215975] PDB:4EPU [DatabaseIdentifier:12215972] PDB:4JYO [DatabaseIdentifier:12135308] Orphanet:ANGPT1 [DatabaseIdentifier:12130654] OpenTargets:ENSG00000154188 [DatabaseIdentifier:11846001] HPA:ENSG00000154188-ANGPT1 [DatabaseIdentifier:11809067] GlyGen:Q15389 [DatabaseIdentifier:11793012] GeneCards:ANGPT1 [DatabaseIdentifier:11733279] ENSEMBL:ENST00000517746 [DatabaseIdentifier:11733280] ENSEMBL:ENST00000297450 [DatabaseIdentifier:11610581] ENSEMBL:ENSP00000297450 [DatabaseIdentifier:11610580] ENSEMBL:ENSP00000428340 [DatabaseIdentifier:11500471] ENSEMBL:ENSG00000154188
databaseName	UniProt
dbId	49784
description	recommendedName: Angiopoietin-1 shortName: ANG-1
displayName	UniProt:Q15389 ANGPT1
geneName	ANGPT1 KIAA0003
identifier	Q15389
isSequenceChanged	false
keyword	3D-structure Alternative splicing Angiogenesis Coiled coil Developmental protein Differentiation Disease variant Disulfide bond Glycoprotein Proteomics identification Reference proteome Secreted Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	ANGPT1
otherIdentifier	11726691_a_at 11726692_at 11726693_s_at 11762193_at 1552939_PM_at 1552939_at 17080082 1929_at 205608_PM_s_at 205608_s_at 205609_PM_at 205609_at 284 3148464 3148465 3148466 3148468 3148472 3148473 3148475 3148476 3148478 3148479 3148480 3148481 3148486 3148488 3148510 3148511 3148512 3148513 39315_at 8152297 A_23_P216023 A_23_P431900 A_24_P60887 D13628_at GE57062 GO:0001525 GO:0001568 GO:0001701 GO:0002040 GO:0002092 GO:0002719 GO:0003013 GO:0005102 GO:0005515 GO:0005576 GO:0005615 GO:0005886 GO:0005902 GO:0006790 GO:0007155 GO:0007162 GO:0007169 GO:0007171 GO:0007596 GO:0010595 GO:0010628 GO:0014842 GO:0030097 GO:0030154 GO:0030195 GO:0030210 GO:0030971 GO:0031398 GO:0031589 GO:0032680 GO:0034394 GO:0042308 GO:0042802 GO:0043066 GO:0043116 GO:0043122 GO:0043524 GO:0043536 GO:0045121 GO:0045785 GO:0048014 GO:0048018 GO:0048856 GO:0050731 GO:0050820 GO:0050918 GO:0051240 GO:0051402 GO:0051897 GO:0065003 GO:0070062 GO:0070374 GO:0072012 GO:0098772 GO:1900747 GO:1901135 GO:1905605 GO:2000352 GO:2000446 HMNXSV003015553 Hs2.2463.2.S1_3p_at ILMN_1677723 ILMN_2086890 PH_hs_0000329 TC08001521.hg g1907326_3p_a_at g4502086_3p_at
physicalEntity	[EntityWithAccessionedSequence:R-HSA-204854] ANGPT1 [extracellular region] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12756524] UCSC:Q15389 ANGPT1 [ReferenceDNASequence:12115190] OMIM:601667 ANGPT1 [ReferenceDNASequence:12079652] NCBI Gene:284 ANGPT1 [ReferenceDNASequence:11995559] Monarch:284 ANGPT1 [ReferenceDNASequence:11904251] KEGG:hsa:284 ANGPT1 [ReferenceDNASequence:11824699] HGNC:484 ANGPT1 [ReferenceDNASequence:11439480] dbSNP Gene:284 ANGPT1 [ReferenceDNASequence:11421354] CTD Gene:284 ANGPT1 [ReferenceDNASequence:11402046] COSMIC - genes:ANGPT1 ANGPT1 [ReferenceDNASequence:11365770] BioGPS Gene:284 ANGPT1 [ReferenceDNASequence:ensembl:ENSG00000154188] ENSEMBL:ENSG00000154188 ANGPT1
referenceTranscript	[ReferenceRNASequence:12610764] RefSeq:NM_001314051.1 ANGPT1 [ReferenceRNASequence:12610766] RefSeq:NM_001146.4 ANGPT1 [ReferenceRNASequence:12610765] RefSeq:NM_001199859.3 ANGPT1
schemaClass	ReferenceGeneProduct
secondaryIdentifier	ANGP1_HUMAN Q5HYA0
sequenceLength	498
species	[Species:48887] Homo sapiens
stId	uniprot:Q15389
url	http://purl.uniprot.org/uniprot/Q15389

Referrals

(interactor)	[UndirectedInteraction:11133519] UniProt:Q15389 <-> UniProt:Q15389 (IntAct) [UndirectedInteraction:11133519] UniProt:Q15389 <-> UniProt:Q15389 (IntAct) [UndirectedInteraction:11133517] UniProt:Q15389 <-> UniProt:Q02763 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-204854] ANGPT1 [extracellular region]