UniProt:Q15291 RBBP5

chain
  • chain:1-538
checksum 095CCB41613CBED9
comment
  • FUNCTION In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653).SUBUNIT Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 (PubMed:16253997, PubMed:17355966, PubMed:17998332, PubMed:18838538). Core component of several methyltransferase-containing complexes including MLL1/MLL, MLL2/3 (also named ASCOM complex) and MLL4/WBP7 (PubMed:15199122, PubMed:15960975, PubMed:17500065). Each complex is at least composed of ASH2L, RBBP5, WDR5, DPY30, one or more specific histone methyltransferases (KMT2A/MLL1, KMT2D/MLL2, KMT2C/MLL3 and KMT2B/MLL4), and the facultative components PAGR1, BACC1, CHD8, E2F6, HCFC1, HCFC2, HSP70, INO80C, KDM6A, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, MYST1/MOF, NCOA6, PAXIP1/PTIP, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9, TEX10 and alpha- and beta-tubulin (PubMed:14992727, PubMed:15199122, PubMed:15960975, PubMed:17500065). Component of a histone methylation complex composed of at least ZNF335, RBBP5, ASH2L and WDR5; the complex may have histone H3-specific methyltransferase activity, however does not have specificity for 'Lys-4' of histone H3 (PubMed:19131338). Interacts with ZNF335 (PubMed:19131338, PubMed:23178126). Interacts with ASH2L; the interaction is direct (PubMed:19131338, PubMed:19556245, PubMed:21220120). Interacts with WDR5; the interaction is direct (PubMed:19556245, PubMed:21220120). Components of the ZNF335-RBBP5-ASH2L-WDR5 histone methylation complex may associate with components of a nuclear receptor-mediated transcription complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (PubMed:19131338). Within this complex interacts with EMSY (PubMed:19131338). Found in a complex with RBBP5, ASH2L, DPY30, KMT2A, KMT2D and WDR5 (By similarity). Interacts with SETD1A (PubMed:17998332). Interacts with WDR82 (PubMed:18838538).INTERACTION Ubiquitously expressed.
crossReference
databaseName UniProt
dbId 62838
description
  • recommendedName: Retinoblastoma-binding protein 5 shortName: RBBP-5 alternativeName: Retinoblastoma-binding protein RBQ-3
displayName UniProt:Q15291 RBBP5
geneName
  • RBBP5
  • RBQ3
identifier Q15291
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Chromatin regulator
  • Isopeptide bond
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Repeat
  • Transcription
  • Transcription regulation
  • Ubl conjugation
  • WD repeat
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • RBBP5
otherIdentifier
  • 11736179_a_at
  • 11736180_x_at
  • 11749736_a_at
  • 11760373_at
  • 16698421
  • 16698425
  • 205169_3p_at
  • 205169_PM_at
  • 205169_at
  • 2452313
  • 2452314
  • 2452315
  • 2452316
  • 2452318
  • 2452320
  • 2452321
  • 2452325
  • 2452326
  • 2452327
  • 2452328
  • 2452329
  • 2452330
  • 2452331
  • 2452332
  • 2452333
  • 2452334
  • 2452335
  • 2452336
  • 2452337
  • 2452339
  • 2452341
  • 2452342
  • 36769_at
  • 5929
  • 62692_at
  • 71534_at
  • 7923707
  • 7923712
  • ADDON002767.hg
  • A_23_P201887
  • A_24_P299794
  • A_33_P3235640
  • A_33_P3235642
  • GE60098
  • GO:0000976
  • GO:0005515
  • GO:0005634
  • GO:0005654
  • GO:0005730
  • GO:0006325
  • GO:0006974
  • GO:0035097
  • GO:0042393
  • GO:0043627
  • GO:0044665
  • GO:0044666
  • GO:0045815
  • GO:0048188
  • GO:0071339
  • HMNXSV003014266
  • HMNXSV003057258
  • ILMN_1696532
  • PH_hs_0004196
  • PH_hs_0017599
  • PH_hs_0035447
  • TC01003741.hg
  • TC01003742.hg
  • X85134_rna1_at
  • g4826969_3p_at
  • g4826969_3p_x_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • RBBP5_HUMAN
  • A8K272
  • Q7Z6D8
  • Q8NDZ7
sequenceLength 538
species [Species:48887] Homo sapiens
stId uniprot:Q15291
url http://purl.uniprot.org/uniprot/Q15291

Referrals

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