Reactome | UniProt:Q15084 PDIA6

chain	signal peptide:1-19 chain:20-440
checksum	06895409F0265D7C
comment	FUNCTION May function as a chaperone that inhibits aggregation of misfolded proteins (PubMed:12204115). Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling (PubMed:24508390). May also regulate the UPR via the EIF2AK3 UPR sensor (PubMed:24508390). Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin (PubMed:15466936).CATALYTIC ACTIVITY Catalyzes the rearrangement of -S-S- bonds in proteins.SUBUNIT Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGGT1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX (PubMed:12475965). Interacts with MICA on the surface of tumor cells, leading to MICA disulfide bond reduction which is required for its release from tumor cells (PubMed:17495932). Interacts with ITGB3 following platelet stimulation (PubMed:15466936). Interacts with ERN1; the interaction is direct (PubMed:24508390). Interacts with EIF2AK3 (PubMed:24508390).INTERACTION Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545).ALTERNATIVE PRODUCTS Expressed in platelets (at protein level).SIMILARITY Belongs to the protein disulfide isomerase family.
created	[InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35
crossReference	[DatabaseIdentifier:12205133] PDB:8CPQ [DatabaseIdentifier:12423311] RefSeq:NP_005733.1 [DatabaseIdentifier:12423312] RefSeq:NP_001269636.1 [DatabaseIdentifier:12423310] RefSeq:NP_001269635.1 [DatabaseIdentifier:12423314] RefSeq:NP_001269634.1 [DatabaseIdentifier:12423313] RefSeq:NP_001269633.1 [DatabaseIdentifier:12288692] Pharos - Targets:Q15084 [DatabaseIdentifier:12249944] PRO:Q15084 [DatabaseIdentifier:12205134] PDB:3VWW [DatabaseIdentifier:12205130] PDB:1X5D [DatabaseIdentifier:11497524] ENSEMBL:ENSG00000143870 [DatabaseIdentifier:11606405] ENSEMBL:ENSP00000481892 [DatabaseIdentifier:11606402] ENSEMBL:ENSP00000438778 [DatabaseIdentifier:11606403] ENSEMBL:ENSP00000385385 [DatabaseIdentifier:11606406] ENSEMBL:ENSP00000371024 [DatabaseIdentifier:11606407] ENSEMBL:ENSP00000384459 [DatabaseIdentifier:11606404] ENSEMBL:ENSP00000272227 [DatabaseIdentifier:11729101] ENSEMBL:ENST00000540494 [DatabaseIdentifier:11729104] ENSEMBL:ENST00000404824 [DatabaseIdentifier:11729105] ENSEMBL:ENST00000381611 [DatabaseIdentifier:11729106] ENSEMBL:ENST00000404371 [DatabaseIdentifier:11729102] ENSEMBL:ENST00000272227 [DatabaseIdentifier:11729103] ENSEMBL:ENST00000617249 [DatabaseIdentifier:11790851] GeneCards:PDIA6 [DatabaseIdentifier:11806785] GlyGen:Q15084 [DatabaseIdentifier:11843855] HPA:ENSG00000143870-PDIA6 [DatabaseIdentifier:12128471] OpenTargets:ENSG00000143870 [DatabaseIdentifier:12205131] PDB:4EF0 [DatabaseIdentifier:12205132] PDB:4GWR [DatabaseIdentifier:12147620] PDB:3W8J
databaseName	UniProt
dbId	405822
description	recommendedName: Protein disulfide-isomerase A6 ecNumber evidence="5 9"5.3.4.1 alternativeName: Endoplasmic reticulum protein 5 shortName: ER protein 5 shortName: ERp5 alternativeName: Protein disulfide isomerase P5 alternativeName: Thioredoxin domain-containing protein 7
displayName	UniProt:Q15084 PDIA6
geneName	PDIA6 ERP5 P5 TXNDC7
identifier	Q15084
isSequenceChanged	false
keyword	3D-structure Alternative splicing Cell membrane Chaperone Direct protein sequencing Disulfide bond Endoplasmic reticulum Isomerase Membrane Phosphoprotein Proteomics identification Redox-active center Reference proteome Repeat Signal
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	PDIA6
otherIdentifier	10130 11715434_a_at 11745720_s_at 11749778_a_at 16894452 207668_PM_x_at 207668_x_at 208638_PM_at 208638_at 208639_PM_x_at 208639_x_at 216640_PM_s_at 216640_s_at 2540321 2540322 2540323 2540326 2540329 2540331 2540332 2540333 2540334 2540335 2540337 2540341 2540342 2540344 2540345 2540348 2540350 2540354 2540355 2540356 41750_at 74808_s_at 8050278 A_24_P319715 D49489_at GE61375 GO:0003756 GO:0003824 GO:0005515 GO:0005615 GO:0005783 GO:0005788 GO:0005789 GO:0005793 GO:0005815 GO:0005886 GO:0005929 GO:0006457 GO:0015035 GO:0016020 GO:0016491 GO:0016853 GO:0034451 GO:0034663 GO:0034976 GO:0036064 GO:0042470 GO:0043226 GO:0070062 GO:0140096 HMNXSV003029351 HMNXSV003040605 Hs.182429.1.S2_3p_at Hs.182429.2.S1_3p_a_at ILMN_1680626 PH_hs_0023080 TC02001573.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-3009049] PDIA6 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-8957031] p-PDIA6 [endoplasmic reticulum lumen] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-535530] PDIA6 [endoplasmic reticulum membrane] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:ensembl:ENSG00000143870] ENSEMBL:ENSG00000143870 PDIA6 [ReferenceDNASequence:12754633] UCSC:Q15084 PDIA6 [ReferenceDNASequence:11363042] BioGPS Gene:10130 PDIA6 [ReferenceDNASequence:11401920] COSMIC - genes:PDIA6 PDIA6 [ReferenceDNASequence:11418371] CTD Gene:10130 PDIA6 [ReferenceDNASequence:11439333] dbSNP Gene:10130 PDIA6 [ReferenceDNASequence:11822514] HGNC:30168 PDIA6 [ReferenceDNASequence:11901836] KEGG:hsa:10130 PDIA6 [ReferenceDNASequence:11992831] Monarch:10130 PDIA6 [ReferenceDNASequence:12076924] NCBI Gene:10130 PDIA6 [ReferenceDNASequence:12113231] OMIM:611099 PDIA6
referenceTranscript	[ReferenceRNASequence:12604899] RefSeq:NM_001282706.2 PDIA6 [ReferenceRNASequence:12604897] RefSeq:NM_001282704.2 PDIA6 [ReferenceRNASequence:12604900] RefSeq:NM_001282707.2 PDIA6 [ReferenceRNASequence:12604898] RefSeq:NM_001282705.2 PDIA6 [ReferenceRNASequence:12604901] RefSeq:NM_005742.4 PDIA6
schemaClass	ReferenceGeneProduct
secondaryIdentifier	PDIA6_HUMAN B3KY95 B5MCQ5 B7Z254 B7Z4M8 F8WA83 Q53RC7 Q6ZSH5 Q99778
sequenceLength	440
species	[Species:48887] Homo sapiens
stId	uniprot:Q15084
url	http://purl.uniprot.org/uniprot/Q15084

(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-3009049] PDIA6 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-8957031] p-PDIA6 [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-HSA-535530] PDIA6 [endoplasmic reticulum membrane]
(referenceSequence)	[ModifiedResidue:8957093] phosphorylated residue at unknown position
(interactor)	[UndirectedInteraction:11139963] UniProt:Q16881 <-> UniProt:Q15084 (IntAct) [UndirectedInteraction:11148187] UniProt:P13569 <-> UniProt:Q15084 (IntAct) [UndirectedInteraction:11163351] UniProt:P11021 <-> UniProt:Q15084 (IntAct) [UndirectedInteraction:11225723] UniProt:P03372 <-> UniProt:Q15084 (IntAct) [UndirectedInteraction:11273723] UniProt:P05067 <-> UniProt:Q15084 (IntAct) [UndirectedInteraction:11292957] UniProt:Q15084 <-> UniProt:O43681 (IntAct) [UndirectedInteraction:11292959] UniProt:Q15084 <-> UniProt:Q96EQ0 (IntAct) [UndirectedInteraction:11292961] UniProt:Q15084 <-> UniProt:P49286 (IntAct) [UndirectedInteraction:11292963] UniProt:Q15084 <-> UniProt:Q13618 (IntAct) [UndirectedInteraction:11292965] UniProt:Q15084 <-> UniProt:P48039 (IntAct) [UndirectedInteraction:11292967] UniProt:Q15084 <-> UniProt:Q13162 (IntAct) [UndirectedInteraction:11292969] UniProt:Q15084 <-> UniProt:P03366 (IntAct)

UniProt:Q15084 PDIA6 Show undefined attributes

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