UniProt:Q15080 NCF4

chain
  • chain:1-339
checksum D82FE9E5BA12890B
comment
  • FUNCTION Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (Probable). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction (By similarity). Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity).SUBUNIT Component of the phagocyte NADPH oxidase complex composed of an obligatory core heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic regulatory subunits NCF1/p47-phox, NCF2/p67-phox, NCF4/p40-phox and the small GTPase RAC1 or RAC2 (Probable). Part of a cytosolic complex composed at least by NCF1, NCF2 and NCF4 (PubMed:8280052). Interacts with NCF2 and NCF1 (PubMed:12887891, PubMed:15657040). The NCF2-NCF4 complex interacts with GBP7 (via GB1/RHD3-type G domain) (By similarity).INTERACTION Translocates to the membrane upon activation by phorbol myristate acetate (PMA).ALTERNATIVE PRODUCTS Expression is restricted to hematopoietic cells.DOMAIN The PB1 domain mediates the association with NCF2/p67-PHOX.DOMAIN The PX domain mediates interaction with membranes enriched in phosphatidylnositol 3-phosphate.DISEASE The disease is caused by variants affecting the gene represented in this entry.
crossReference
databaseName UniProt
dbId 59969
description
  • recommendedName: fullName evidence="18"Neutrophil cytosol factor 4 shortName: NCF-4 alternativeName: Neutrophil NADPH oxidase factor 4 alternativeName: SH3 and PX domain-containing protein 4 alternativeName: p40-phox shortName: p40phox
displayName UniProt:Q15080 NCF4
geneName
  • NCF4
  • SH3PXD4
identifier Q15080
isSequenceChanged false
keyword
  • 3D-structure
  • Alternative splicing
  • Chronic granulomatous disease
  • Cytoplasm
  • Direct protein sequencing
  • Disease variant
  • Endosome
  • Lipid-binding
  • Membrane
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • SH3 domain
modified [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
moleculeType Protein
name
  • NCF4
otherIdentifier
  • 11723106_a_at
  • 16929662
  • 205147_PM_x_at
  • 205147_x_at
  • 207677_PM_s_at
  • 207677_s_at
  • 38893_at
  • 38894_g_at
  • 38895_i_at
  • 3944544
  • 3944545
  • 3944547
  • 3944548
  • 3944549
  • 3944551
  • 3944552
  • 3944553
  • 3944554
  • 3944555
  • 3944556
  • 3944557
  • 3944558
  • 3944559
  • 3944560
  • 3944561
  • 4689
  • 8072744
  • A_14_P110052
  • A_23_P109508
  • A_33_P3365432
  • GE62052
  • GO:0005515
  • GO:0005737
  • GO:0005764
  • GO:0005768
  • GO:0005829
  • GO:0005886
  • GO:0006909
  • GO:0008289
  • GO:0010008
  • GO:0016020
  • GO:0016176
  • GO:0016192
  • GO:0031410
  • GO:0032010
  • GO:0032266
  • GO:0035091
  • GO:0042554
  • GO:0043020
  • GO:0045730
  • HMNXSV003054798
  • ILMN_1757361
  • ILMN_1785005
  • ILMN_2335704
  • PH_hs_0027302
  • TC22000270.hg
  • X77094_at
  • g7382492_3p_a_at
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • NCF4_HUMAN
  • A8K4F9
  • O60808
  • Q86U56
  • Q9BU98
  • Q9NP45
sequenceLength 339
species [Species:48887] Homo sapiens
stId uniprot:Q15080
url http://purl.uniprot.org/uniprot/Q15080
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