Reactome | UniProt:Q15021 NCAPD2

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UniProt:Q15021 NCAPD2 Show undefined attributes

chain	chain:1-1401
checksum	35E31642B94B513D
comment	FUNCTION Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain (PubMed:11136719). May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size (PubMed:27737959).SUBUNIT Component of the condensin complex, which contains the SMC2 and SMC4 heterodimer, and three non SMC subunits that probably regulate the complex: NCAPH/BRRN1, NCAPD2/CAPD2 and NCAPG. Interacts with histones H1 and H3.INTERACTION In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.DOMAIN The C-terminal domain interacts with histones H1 and H3, and may be responsible for condensin complex targeting to mitotic chromosomes. This domain is independent from the bipartite nuclear localization signal, although they are contained within the same region.PTM Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity).DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the CND1 (condensin subunit 1) family.SEQUENCE CAUTION Extended N-terminus.
crossReference	[DatabaseIdentifier:12422777] RefSeq:NP_055680.3 [DatabaseIdentifier:12288561] Pharos - Targets:Q15021 [DatabaseIdentifier:12249812] PRO:Q15021 [DatabaseIdentifier:12128340] OpenTargets:ENSG00000010292 [DatabaseIdentifier:11843725] HPA:ENSG00000010292-NCAPD2 [DatabaseIdentifier:11806655] GlyGen:Q15021 [DatabaseIdentifier:11790722] GeneCards:NCAPD2 [DatabaseIdentifier:11728784] ENSEMBL:ENST00000315579 [DatabaseIdentifier:11606085] ENSEMBL:ENSP00000325017 [DatabaseIdentifier:11497368] ENSEMBL:ENSG00000010292
databaseName	UniProt
dbId	87692
description	recommendedName: Condensin complex subunit 1 alternativeName: Chromosome condensation-related SMC-associated protein 1 alternativeName: Chromosome-associated protein D2 shortName: hCAP-D2 alternativeName: Non-SMC condensin I complex subunit D2 alternativeName: XCAP-D2 homolog
displayName	UniProt:Q15021 NCAPD2
geneName	NCAPD2 CAPD2 CNAP1 KIAA0159
identifier	Q15021
isSequenceChanged	false
keyword	Cell cycle Cell division Chromosome Cytoplasm Direct protein sequencing Disease variant DNA condensation Mitosis Nucleus Phosphoprotein Primary microcephaly Proteomics identification Reference proteome
modified	[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType	Protein
name	NCAPD2
otherIdentifier	11744272_a_at 11747606_a_at 16747287 201774_PM_s_at 201774_s_at 3045394 3045417 3402572 3402573 3402574 3402575 3402576 3402580 3402581 3402582 3402584 3402585 3402586 3402587 3402588 3402589 3402590 3402591 3402592 3402593 3402594 3402595 3402597 3402598 3402599 3402600 3402601 3402602 3402603 3402604 3402605 3402606 3402607 3402608 3402609 3402610 3402611 3402612 3402613 3402614 3402615 3402617 3402618 3402619 3402620 3402621 3402622 3402623 3402624 3402626 3402627 3402628 3402629 3402630 3402631 3402632 35314_at 7953351 9918 A_14_P122236 A_23_P25293 A_33_P3303385 D63880_at GE57283 GO:0000228 GO:0000278 GO:0000779 GO:0000793 GO:0000794 GO:0000796 GO:0005515 GO:0005634 GO:0005654 GO:0005694 GO:0005737 GO:0005815 GO:0005829 GO:0007076 GO:0010032 GO:0016020 GO:0030261 GO:0034451 GO:0036064 GO:0042393 GO:0051301 GO:0051984 GO:1905820 GO:1905821 HMNXSV003035402 Hs.5719.0.S1_3p_a_at Hs2.380041.1.S1_3p_s_at ILMN_1775008 PH_hs_0000579 TC12000082.hg
physicalEntity	[EntityWithAccessionedSequence:R-HSA-2517887] p-T1339,T1384,T1389-NCAPD2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2529011] p-S-NCAPD2 [cytosol] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-1638140] NCAPD2 [cytosol] - Homo sapiens
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:12754496] UCSC:Q15021 NCAPD2 [ReferenceDNASequence:12113110] OMIM:615638 NCAPD2 [ReferenceDNASequence:12076768] NCBI Gene:9918 NCAPD2 [ReferenceDNASequence:11992675] Monarch:9918 NCAPD2 [ReferenceDNASequence:11901692] KEGG:hsa:9918 NCAPD2 [ReferenceDNASequence:11822383] HGNC:24305 NCAPD2 [ReferenceDNASequence:11439295] dbSNP Gene:9918 NCAPD2 [ReferenceDNASequence:11418212] CTD Gene:9918 NCAPD2 [ReferenceDNASequence:11401885] COSMIC - genes:NCAPD2 NCAPD2 [ReferenceDNASequence:11362886] BioGPS Gene:9918 NCAPD2 [ReferenceDNASequence:ensembl:ENSG00000010292] ENSEMBL:ENSG00000010292 NCAPD2
referenceTranscript	[ReferenceRNASequence:12604361] RefSeq:NM_014865.3 NCAPD2
schemaClass	ReferenceGeneProduct
secondaryIdentifier	CND1_HUMAN D3DUR4 Q8N6U3
sequenceLength	1401
species	[Species:48887] Homo sapiens
stId	uniprot:Q15021
url	http://purl.uniprot.org/uniprot/Q15021

Referrals

(interactor)	[UndirectedInteraction:11275965] UniProt:P12273 <-> UniProt:Q15021 (IntAct) [UndirectedInteraction:11149365] UniProt:P13569 <-> UniProt:Q15021 (IntAct)
(referenceEntity)	[EntityWithAccessionedSequence:R-HSA-2517887] p-T1339,T1384,T1389-NCAPD2 [cytosol] [EntityWithAccessionedSequence:R-HSA-2529011] p-S-NCAPD2 [cytosol] [EntityWithAccessionedSequence:R-HSA-1638140] NCAPD2 [cytosol]
(referenceSequence)	[ModifiedResidue:2517881] O-phospho-L-threonine at 1389 [ModifiedResidue:2517880] O-phospho-L-threonine at 1339 [ModifiedResidue:2517884] O-phospho-L-threonine at 1384 [ModifiedResidue:2529010] O-phospho-L-serine at unknown position

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