UniProt:Q14CW9 ATXN7L3

chain
  • chain:1-347
checksum 742D85BFF4ADD0C0
comment
  • FUNCTION Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B (PubMed:18206972, PubMed:21746879). The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex (PubMed:18206972). Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B (PubMed:27601583).SUBUNIT Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module) (PubMed:18206972, PubMed:21746879, PubMed:27601583). Interacts directly with ENY2 and USP22 (PubMed:18206972).INTERACTION The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module.DOMAIN The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.SIMILARITY Belongs to the SGF11 family.
created [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53
crossReference
databaseName UniProt
dbId 219486
description
  • recommendedName: fullName evidence="1"Ataxin-7-like protein 3 alternativeName: fullName evidence="1"SAGA-associated factor 11 homolog
displayName UniProt:Q14CW9 ATXN7L3
geneName
  • ATXN7L3
identifier Q14CW9
isSequenceChanged false
keyword
  • 3D-structure
  • Activator
  • Alternative splicing
  • Chromatin regulator
  • Metal-binding
  • Nucleus
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transcription
  • Transcription regulation
  • Zinc
  • Zinc-finger
modified [InstanceEdit:9926675] Weiser, Joel, 2024-11-03
moleculeType Protein
name
  • ATXN7L3
otherIdentifier
  • 11717880_a_at
  • 11717881_a_at
  • 16845574
  • 224969_PM_at
  • 224969_at
  • 3758941
  • 3758942
  • 3758943
  • 3758944
  • 3758945
  • 3758946
  • 3758947
  • 3758948
  • 3758949
  • 3758950
  • 3758951
  • 3758952
  • 3758953
  • 3758954
  • 3758955
  • 3758956
  • 3758957
  • 3758958
  • 3758959
  • 3758960
  • 3758961
  • 3758962
  • 3758963
  • 3758965
  • 3758966
  • 45258_at
  • 56970
  • 8015955
  • A_23_P421935
  • GE579172
  • GE85070
  • GO:0000124
  • GO:0003713
  • GO:0005515
  • GO:0005634
  • GO:0006282
  • GO:0006325
  • GO:0006355
  • GO:0006357
  • GO:0008270
  • GO:0033276
  • GO:0043484
  • GO:0045893
  • GO:0046872
  • GO:0070461
  • GO:0071819
  • HMNXSV003011038
  • Hs.181391.0.S1_3p_at
  • ILMN_1862018
  • PH_hs_0026794
  • TC17001575.hg
physicalEntity
referenceDatabase [ReferenceDatabase:2] UniProt
referenceGene
referenceTranscript
schemaClass ReferenceGeneProduct
secondaryIdentifier
  • AT7L3_HUMAN
  • Q8IY68
  • Q96N40
  • Q9NPU5
sequenceLength 347
species [Species:48887] Homo sapiens
stId uniprot:Q14CW9
url http://purl.uniprot.org/uniprot/Q14CW9
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